Personal profile
Research interests
The Strauch Lab uses both computational and experimental methodologies to understand, inhibit and re-purpose biological processes on the protein level. The main focus of Dr. Strauch’s research is on how to diagnose, prevent and treat viral infections with the aim to generate new antivirals and candidates for vaccination through protein design. For that, her lab develops and uses new cutting-edge technologies involving structural design as well as pooled oligo-synthesis and next-generation sequencing. While her team in the lab studies viral surface proteins principally to understand how they can target them or provide new immunogens, they also seek to shed light on how protein chemistry is involved in making viruses so successful. Viruses and their surface proteins hold the molecuar keys for identifying speciic host cells, entering them and re-programming them — much of what is needed to fight cancer.
Available to Mentor:
- PhD Students
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Collaborations and top research areas from the last five years
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An intranasal adenoviral-vectored vaccine protects against highly pathogenic avian influenza H5N1 in naive and antigen-experienced animals
Ying, B., Pyles, K., Darling, T. L., Seehra, K., Pham, T., Huang, L. C., Harastani, H. H., Sharma, A., Desai, P., Kashentseva, E. A., Curiel, D. T., Peters, B., Case, J. B., Strauch, E. M., Diamond, M. S. & Boon, A. C. M., Feb 17 2026, In: Cell Reports Medicine. 7, 2, p. 102582 1 p.Research output: Contribution to journal › Article › peer-review
Open Access -
A general computational design strategy for stabilizing viral class I fusion proteins
Gonzalez, K. J., Huang, J., Criado, M. F., Banerjee, A., Tompkins, S. M., Mousa, J. J. & Strauch, E. M., Dec 2024, In: Nature communications. 15, 1, 1335.Research output: Contribution to journal › Article › peer-review
Open Access13 Link opens in a new tab Scopus citations -
Systematic computer-aided disulfide design as a general strategy to stabilize prefusion class I fusion proteins
Gonzalez, K. J., Yim, K. C., Blanco, J. C. G., Boukhvalova, M. S. & Strauch, E. M., 2024, In: Frontiers in immunology. 15, 1406929.Research output: Contribution to journal › Article › peer-review
Open Access5 Link opens in a new tab Scopus citations -
Deep learning of protein sequence design of protein–protein interactions
Syrlybaeva, R. & Strauch, E. M., Jan 1 2023, In: Bioinformatics. 39, 1, btac733.Research output: Contribution to journal › Article › peer-review
Open Access17 Link opens in a new tab Scopus citations -
Epitopes in the Glycosylphosphatidylinositol Attachment Signal Peptide of Trypanosoma cruzi Mucin Proteins Generate Robust but Delayed and Nonprotective CD8+ T Cell Responses
Bunkofske, M. E., Perumal, N., White, B., Strauch, E. M. & Tarleton, R., Feb 15 2023, In: Journal of Immunology. 210, 4, p. 420-430 11 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Link opens in a new tab Scopus citations