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Eva Istvan

Associate Professor of Medicine, HHMI Specialist II

    • 3650
      Citations
    1995 …2024

    Research activity per year

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    • Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase

      Xie, S. C., Wang, Y., Morton, C. J., Metcalfe, R. D., Dogovski, C., Pasaje, C. F. A., Dunn, E., Luth, M. R., Kumpornsin, K., Istvan, E. S., Park, J. S., Fairhurst, K. J., Ketprasit, N., Yeo, T., Yildirim, O., Bhebhe, M. N., Klug, D. M., Rutledge, P. J., Godoy, L. C. & Dey, S. & 24 others, De Souza, M. L., Siqueira-Neto, J. L., Du, Y., Puhalovich, T., Amini, M., Shami, G., Loesbanluechai, D., Nie, S., Williamson, N., Jana, G. P., Maity, B. C., Thomson, P., Foley, T., Tan, D. S., Niles, J. C., Han, B. W., Goldberg, D. E., Burrows, J., Fidock, D. A., Lee, M. C. S., Winzeler, E. A., Griffin, M. D. W., Todd, M. H. & Tilley, L., Dec 2024, In: Nature communications. 15, 1, 937.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      2 Scopus citations

    • Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance

      Luth, M. R., Godinez-Macias, K. P., Chen, D., Okombo, J., Thathy, V., Cheng, X., Daggupati, S., Davies, H., Dhingra, S. K., Economy, J. M., Edgar, R. C. S., Gomez-Lorenzo, M. G., Istvan, E. S., Jado, J. C., LaMonte, G. M., Melillo, B., Mok, S., Narwal, S. K., Ndiaye, T. & Ottilie, S. & 28 others, Palomo Diaz, S., Park, H., Peña, S., Rocamora, F., Sakata-Kato, T., Small-Saunders, J. L., Summers, R. L., Tumwebaze, P. K., Vanaerschot, M., Xia, G., Yeo, T., You, A., Gamo, F. J., Goldberg, D. E., Lee, M. C. S., McNamara, C. W., Ndiaye, D., Rosenthal, P. J., Schreiber, S. L., Serra, G., De Siqueira-Neto, J. L., Skinner-Adams, T. S., Uhlemann, A. C., Kato, N., Lukens, A. K., Wirth, D. F., Fidock, D. A. & Winzeler, E. A., Nov 29 2024, In: Science (New York, N.Y.). 386, 6725, p. eadk9893

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • The Plasmodium falciparum NCR1 transporter is an antimalarial target that exports cholesterol from the parasite's plasma membrane

      Zhang, Z., Lyu, M., Han, X., Bandara, S., Cui, M., Istvan, E. S., Geng, X., Tringides, M. L., Gregor, W. D., Miyagi, M., Oberstaller, J., Adams, J. H., Zhang, Y., Nieman, M. T., von Lintig, J., Goldberg, D. & Yu, E. W., Dec 20 2024, In: Science Advances. 10, 51, p. eadq6651

      Research output: Contribution to journal › Article › peer-review

    • Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target

      Istvan, E. S., Guerra, F., Abraham, M., Huang, K. S., Rocamora, F., Zhao, H., Xu, L., Pasaje, C., Kumpornsin, K., Luth, M. R., Cui, H., Yang, T., Diaz, S. P., Gomez-Lorenzo, M. G., Qahash, T., Mittal, N., Ottilie, S., Niles, J., Lee, M. C. S. & Llinas, M. & 7 others, Kato, N., Okombo, J., Fidock, D. A., Schimmel, P., Gamo, F. J., Goldberg, D. E. & Winzeler, E. A., Mar 8 2023, In: Science translational medicine. 15, 686, eadc9249.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      10 Scopus citations

    • Human Polo-like Kinase Inhibitors as Antiplasmodials

      Bohmer, M. J., Wang, J., Istvan, E. S., Luth, M. R., Collins, J. E., Huttlin, E. L., Wang, L., Mittal, N., Hao, M., Kwiatkowski, N. P., Gygi, S. P., Chakrabarti, R., Deng, X., Goldberg, D. E., Winzeler, E. A., Gray, N. S. & Chakrabarti, D., Apr 14 2023, In: ACS Infectious Diseases. 9, 4, p. 1004-1021 18 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      2 Scopus citations
    View all 32 Research outputs