Eva Istvan

Associate Professor of Medicine, HHMI Specialist II

    • 3455
    1995 …2024

    Research activity per year


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    • Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase

      Xie, S. C., Wang, Y., Morton, C. J., Metcalfe, R. D., Dogovski, C., Pasaje, C. F. A., Dunn, E., Luth, M. R., Kumpornsin, K., Istvan, E. S., Park, J. S., Fairhurst, K. J., Ketprasit, N., Yeo, T., Yildirim, O., Bhebhe, M. N., Klug, D. M., Rutledge, P. J., Godoy, L. C., Dey, S., & 24 othersDe Souza, M. L., Siqueira-Neto, J. L., Du, Y., Puhalovich, T., Amini, M., Shami, G., Loesbanluechai, D., Nie, S., Williamson, N., Jana, G. P., Maity, B. C., Thomson, P., Foley, T., Tan, D. S., Niles, J. C., Han, B. W., Goldberg, D. E., Burrows, J., Fidock, D. A., Lee, M. C. S., Winzeler, E. A., Griffin, M. D. W., Todd, M. H. & Tilley, L., Dec 2024, In: Nature communications. 15, 1, 937.

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target

      Istvan, E. S., Guerra, F., Abraham, M., Huang, K. S., Rocamora, F., Zhao, H., Xu, L., Pasaje, C., Kumpornsin, K., Luth, M. R., Cui, H., Yang, T., Diaz, S. P., Gomez-Lorenzo, M. G., Qahash, T., Mittal, N., Ottilie, S., Niles, J., Lee, M. C. S., Llinas, M., & 7 othersKato, N., Okombo, J., Fidock, D. A., Schimmel, P., Gamo, F. J., Goldberg, D. E. & Winzeler, E. A., Mar 8 2023, In: Science translational medicine. 15, 686, eadc9249.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      5 Scopus citations
    • Human Polo-like Kinase Inhibitors as Antiplasmodials

      Bohmer, M. J., Wang, J., Istvan, E. S., Luth, M. R., Collins, J. E., Huttlin, E. L., Wang, L., Mittal, N., Hao, M., Kwiatkowski, N. P., Gygi, S. P., Chakrabarti, R., Deng, X., Goldberg, D. E., Winzeler, E. A., Gray, N. S. & Chakrabarti, D., Apr 14 2023, In: ACS Infectious Diseases. 9, 4, p. 1004-1021 18 p.

      Research output: Contribution to journalArticlepeer-review

      2 Scopus citations
    • The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance

      Murithi, J. M., Deni, I., Pasaje, C. F. A., Okombo, J., Bridgford, J. L., Gnädig, N. F., Edwards, R. L., Yeo, T., Mok, S., Burkhard, A. Y., Coburn-Flynn, O., Istvan, E. S., Sakata-Kato, T., Gomez-Lorenzo, M. G., Cowell, A. N., Wicht, K. J., Le Manach, C., Kalantarov, G. F., Dey, S., Duffey, M., & 13 othersLaleu, B., Lukens, A. K., Ottilie, S., Vanaerschot, M., Trakht, I. N., Gamo, F. J., Wirth, D. F., Goldberg, D. E., Odom John, A. R., Chibale, K., Winzeler, E. A., Niles, J. C. & Fidock, D. A., May 19 2022, In: Cell Chemical Biology. 29, 5, p. 824-839.e6

      Research output: Contribution to journalArticlepeer-review

      Open Access
      13 Scopus citations
    • MalDA, Accelerating Malaria Drug Discovery

      the Malaria Drug Accelerator Consortium, Jun 2021, In: Trends in Parasitology. 37, 6, p. 493-507 15 p.

      Research output: Contribution to journalReview articlepeer-review

      Open Access
      46 Scopus citations