Personal profile
Research interests
Molecular mechanisms of neurodegeneration, with a special interest in oxidative stress; role of circadian clock genes in the regulation of brain oxidative stress, bioenergetics, and neurodegeneration; how proteins associated with neurodegenerative disease, such as Apolipoprotein E, modulate oxidative stress responses in the brain; phenotypic and biochemical similarities between autosomal dominant (familial) and sporadic Alzheimer’s Disease, as well as to employ mass spectrometry and PET-based amyloid imaging techniques to elucidate the relationship between brain amyloid deposition, neuronal oxidative damage, and dementia in living patients
Clinical interests
Cognitive disorders, Alzheimer's Disease, age-related neurodegenerative diseases
Mentoring
The Musiek Lab is a diverse group and we are dedicated to providing a supportive, welcoming environment to all people.
Available to Mentor:
- PhD Students
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
REV-ERB-alpha and -beta coordinately regulate astrocyte reactivity and proteostatic function
Nadarajah, C. J., Li, M. Y., Quillin, E. I., Boyer, K., Dimitry, J. M., Chen, Y., King, M. W., Saliu, I. O., Lee, J., Sheehan, P. W., Davis, A. A., Lazar, M. A., Zhao, G. & Musiek, E. S., Feb 3 2026, In: Proceedings of the National Academy of Sciences of the United States of America. 123, 5, e2511093123.Research output: Contribution to journal › Article › peer-review
Open Access -
A glial circadian gene expression atlas reveals cell-type and disease-specific reprogramming in response to amyloid pathology or aging
Sheehan, P. W., Fass, S. B., Sapkota, D., Kang, S., Hollis, H. C., Lawrence, J. H., Park, S., Sharma, A., Schafer, D. P., Anafi, R. C., Dougherty, J. D., Fryer, J. D. & Musiek, E. S., Nov 2025, In: Nature neuroscience. 28, 11, p. 2366-2379 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Amyloid PET in Sporadic Early- Versus Late-Onset Alzheimer's Disease: Comparison of the LEADS and ADNI Cohorts
the LEADS Consortium for the Alzheimer's Disease Neuroimaging Initiative, Aug 2025, In: Annals of neurology. 98, 2, p. 236-248 13 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Link opens in a new tab Scopus citations -
Anti-amyloid treatments: Why we think they are worth it
Schindler, S. E., Musiek, E. S. & Morris, J. C., Jan 1 2025, In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 11, 1, e70055.Research output: Contribution to journal › Comment/debate
Open Access2 Link opens in a new tab Scopus citations -
ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep
Constantino, N. J., Carroll, C. M., Williams, H. C., Vekaria, H. J., Yuede, C. M., Saito, K., Sheehan, P. W., Snipes, J. A., Raichle, M. E., Musiek, E. S., Sullivan, P. G., Morganti, J. M., Johnson, L. A. & Macauley, S. L., Feb 25 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 8, e2416578122.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Scopus citations