Research output per year
Research output per year
Personal profile
Research interests
The Musiek lab focuses on the cellular and molecular mechanisms by which circadian clocks regulate inflammation in the brain and impact neurodegenerative disease, particularly Alzheimer’s Disease. Our lab has shown that circadian clock genes regulate critical neurodegenerative processes, including neuroinflammation and glial reactivity, lipid and NAD+ metabolism, and amyloid and tau aggregation. Our work has revealed striking alterations in circadian gene expression patterns in specific brain cell types, including astrocyte and microglia, in the setting of AD an aging, in both mice and humans, providing novel insights into AD pathobiology. We also have interest in non-circadian topics, including astrocyte biology in disease, sleep-neurodegeneration interactions, and anti-amyloid antibody therapy for Alzheimer's Disease.
Clinical interests
Cognitive disorders, Alzheimer's Disease, age-related neurodegenerative diseases
Mentoring
The Musiek Lab is a diverse group and we are dedicated to providing a supportive, welcoming environment to all people.
Available to Mentor:
- PhD Students
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Alzheimer's disease polygenic risk in early- and late-onset Alzheimer's disease
for the Longitudinal Early-Onset Alzheimer's Disease Study Consortium and the Alzheimer's Disease Neuroimaging Initiative, Jan 2026, In: Alzheimer's and Dementia. 22, 1, e71066.Research output: Contribution to journal › Article › peer-review
Open Access -
Author Correction: Circadian circuits control plasticity of group 3 innate lymphoid cells by sustaining epigenetic configuration of RORγt (Nature Immunology, (2025), 26, 9, (1527-1539), 10.1038/s41590-025-02240-5)
Bhattarai, B., Antonova, A. U., Fachi, J. L., Hopkins, L. S., McCullen, M. V. D., Saini, A., Oliveira, S. D., Beatty, W. L., Musiek, E. S., Kuchroo, V. K., Lazar, M. A., Oltz, E. M. & Colonna, M., Jun 2026, In: Nature immunology. 27, 6, p. 1306 1 p.Research output: Contribution to journal › Comment/debate
Open Access -
Cognitive dispersion profiles and prediction of cognitive change in early-onset dementias: Results from LEADS
the LEADS Consortium, May 2026, In: Alzheimer's and Dementia. 22, 5, e71492.Research output: Contribution to journal › Article › peer-review
Open Access -
Conditional deletion of Bmal1 modestly alters acute pathology without affecting functional recovery after contusive spinal cord injury
Slomnicki, L. P., Armstrong, C. D., Morehouse, J. R., Andres, K., Musiek, E. S., Ohri, S. S. & Hetman, M., Oct 15 2026, In: Neuroscience Letters. 885, 138707.Research output: Contribution to journal › Article › peer-review
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Criterion and convergent validity of plasma biomarkers in early-onset Alzheimer's disease: Initial findings from LEADS
the LEADS Consortium, Apr 1 2026, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 18, 2, e70342.Research output: Contribution to journal › Article › peer-review
Open Access