Eric Leuthardt

2025

IpsiHand Brain–Computer Interface Therapy Induces Broad Upper Extremity Motor Rehabilitation in Chronic Stroke

Rustamov, N., Souders, L., Sheehan, L., Carter, A. & Leuthardt, E. C., Jan 2025, In: Neurorehabilitation and neural repair. 39, 1, p. 74-86 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Neurocognitive and Resting-State Functional Magnetic Resonance Imaging Changes in Patients With Diffuse Gliomas After Chemoradiation Therapy

Liu, Z., Mitchell, T., Luo, C., Park, K. Y., Shimony, J. S., Fucetola, R., Leuthardt, E. C., Perkins, S., Snyder, A., Zhu, T. & Huang, J., 2025, (Accepted/In press) In: International Journal of Radiation Oncology Biology Physics.

Research output: Contribution to journal › Article › peer-review

Open Access

The effect of transcutaneous auricular vagus nerve stimulation on cardiovascular function in subarachnoid hemorrhage patients: A randomized trial

Tan, G., Huguenard, A. L., Donovan, K. M., Demarest, P., Liu, X., Li, Z., Adamek, M., Lavine, K., Vellimana, A. K., Kummer, T. T., Osbun, J. W., Zipfel, G. J., Brunner, P. & Leuthardt, E. C., Jan 9 2025, In: eLife. 13

Research output: Contribution to journal › Article › peer-review

Open Access

Transcranial vibration stimulation at 40 Hz induced neural activity and promoted the coupling of global brain activity and cerebrospinal fluid flow

Kong, L., Jin, W., Jiang, Y., Yan, F., Liu, J., Leuthardt, E. C., Yang, G. Z. & Feng, Y., Mar 2025, In: NeuroImage. 308, 121074.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2024

A novel theta-controlled vibrotactile brain–computer interface to treat chronic pain: a pilot study

Demarest, P., Rustamov, N., Swift, J., Xie, T., Adamek, M., Cho, H., Wilson, E., Han, Z., Belsten, A., Luczak, N., Brunner, P., Haroutounian, S. & Leuthardt, E. C., Dec 2024, In: Scientific reports. 14, 1, 3433.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

A Phase 1/2 Study of Disulfiram and Copper With Concurrent Radiation Therapy and Temozolomide for Patients With Newly Diagnosed Glioblastoma

Huang, J., Campian, J. L., DeWees, T. A., Skrott, Z., Mistrik, M., Johanns, T. M., Ansstas, G., Butt, O., Leuthardt, E., Dunn, G. P., Zipfel, G. J., Osbun, J. W., Abraham, C., Badiyan, S., Schwetye, K., Cairncross, J. G., Rubin, J. B., Kim, A. H. & Chheda, M. G., Nov 1 2024, In: International Journal of Radiation Oncology Biology Physics. 120, 3, p. 738-749 12 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

CNS-CLIP: Transforming a Neurosurgical Journal into a Multimodal Medical Model

Alyakin, A., Kurland, D., Alber, D. A., Sangwon, K. L., Li, D., Tsirigos, A., Leuthardt, E., Kondziolka, D. & Oermann, E. K., 2024, (Accepted/In press) In: Neurosurgery.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Complexity organization of resting-state functional-MRI networks

Trevino, G., Lee, J. J., Shimony, J. S., Luckett, P. H. & Leuthardt, E. C., Aug 15 2024, In: Human Brain Mapping. 45, 12, e26809.

Research output: Contribution to journal › Article › peer-review

Open Access

Does vibrotactile stimulation of the auricular vagus nerve enhance working memory? A behavioral and physiological investigation

Tan, G., Adams, J., Donovan, K., Demarest, P., Willie, J. T., Brunner, P., Gorlewicz, J. L. & Leuthardt, E. C., Mar 1 2024, In: Brain Stimulation. 17, 2, p. 460-468 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Glioblastoma-Infiltrating CD8⁺ T Cells Are Predominantly a Clonally Expanded GZMK⁺ Effector Population

Wang, A. Z., Mashimo, B. L., Schaettler, M. O., Sherpa, N. D., Leavitt, L. A., Livingstone, A. J., Khan, S. M., Li, M., Anzaldua-Campos, M. I., Bradley, J. D., Leuthardt, E. C., Kim, A. H., Dowling, J. L., Chicoine, M. R., Jones, P. S., Choi, B. D., Cahill, D. P., Carter, B. S., Petti, A. A. & Johanns, T. M. & 1 others, Dunn, G. P., Jun 1 2024, In: Cancer discovery. 14, 6, p. 1106-1131 26 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Non-invasive Auricular Vagus nerve stimulation for Subarachnoid Hemorrhage (NAVSaH): Protocol for a prospective, triple-blinded, randomized controlled trial

Huguenard, A., Tan, G., Johnson, G., Adamek, M., Coxon, A., Kummer, T., Osbun, J., Vellimana, A., Limbrick, D., Zipfel, G., Brunner, P. & Leuthardt, E., Aug 1 2024, In: PloS one. 19, 8, e0301154.

Research output: Contribution to journal › Article › peer-review

Open Access

Optimal approaches to analyzing functional MRI data in glioma patients

Park, K. Y., Shimony, J. S., Chakrabarty, S., Tanenbaum, A. B., Hacker, C. D., Donovan, K. M., Luckett, P. H., Milchenko, M., Sotiras, A., Marcus, D. S., Leuthardt, E. C. & Snyder, A. Z., Feb 2024, In: Journal of Neuroscience Methods. 402, 110011.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Predicting post-surgical functional status in high-grade glioma with resting state fMRI and machine learning

Luckett, P. H., Olufawo, M. O., Park, K. Y., Lamichhane, B., Dierker, D., Verastegui, G. T., Lee, J. J., Yang, P., Kim, A., Butt, O. H., Chheda, M. G., Snyder, A. Z., Shimony, J. S. & Leuthardt, E. C., Aug 2024, In: Journal of Neuro-Oncology. 169, 1, p. 175-185 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Quality assurance for focused ultrasound-induced blood-brain barrier opening procedure using passive acoustic detection

Chien, C. Y., Xu, L., Yuan, J., Fadera, S., Stark, A. H., Athiraman, U., Leuthardt, E. C. & Chen, H., Apr 2024, In: EBioMedicine. 102, 105066.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

2023

A pilot study of lymphoscintigraphy with tracer injection into the human brain

Coxon, A. T., Desai, R., Patel, P. R., Vellimana, A. K., Willie, J. T., Dowling, J. L., Leuthardt, E. C., Kim, A. H., Johanns, T. M., Siegel, B. A. & Dunn, G. P., Aug 2023, In: Journal of Cerebral Blood Flow and Metabolism. 43, 8, p. 1382-1389 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Characterization of the Targeting Accuracy of a Neuronavigation-Guided Transcranial FUS System In Vitro, In Vivo, and In Silico

Xu, L., Pacia, C. P., Gong, Y., Hu, Z., Chien, C. Y., Yang, L., Michael Gach, H., Hao, Y., Comron, H., Huang, J., Leuthardt, E. C. & Chen, H., May 1 2023, In: IEEE Transactions on Biomedical Engineering. 70, 5, p. 1528-1538 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Data-efficient resting-state functional magnetic resonance imaging brain mapping with deep learning

Luckett, P. H., Park, K. Y., Lee, J. J., Lenze, E. J., Wetherell, J. L., Eyler, L. T., Snyder, A. Z., Ances, B. M., Shimony, J. S. & Leuthardt, E. C., 2023, In: Journal of neurosurgery. 139, 5, p. 1258-1269 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Efficacy of laser interstitial thermal therapy for biopsy-proven radiation necrosis in radiographically recurrent brain metastases

Chan, M., Tatter, S., Chiang, V., Fecci, P., Strowd, R., Prabhu, S., Hadjipanayis, C., Kirkpatrick, J., Sun, D., Sinicrope, K., Mohammadi, A. M., Sevak, P., Abram, S., Kim, A. H., Leuthardt, E., Chao, S., Phillips, J., Lacroix, M., Williams, B. & Placantonakis, D. & 4 others, Silverman, J., Baumgartner, J., Piccioni, D. & Laxton, A., Jan 1 2023, In: Neuro-Oncology Advances. 5, 1, vdad031.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Electroactive Spinal Instrumentation for Targeted Osteogenesis and Spine Fusion: A Computational Study

Javeed, S., Zhang, J. K., Greenberg, J. K., Dibble, C. F., Zellmer, E., Moran, D., Leuthardt, E. C., Ray, W. Z. & Macewan, M. R., Feb 1 2023, In: International Journal of Spine Surgery. 17, 1, p. 95-102 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Feasibility and Acceptability of a Preoperative Multimodal Mobile Health Assessment in Spine Surgery Candidates

Greenberg, J. K., Frumkin, M. R., Javeed, S., Zhang, J. K., Dai, R., Molina, C. A., Pennicooke, B. H., Agarwal, N., Santiago, P., Goodwin, M. L., Jain, D., Pallotta, N., Gupta, M. C., Buchowski, J. M., Leuthardt, E. C., Ghogawala, Z., Kelly, M. P., Hall, B. L., Piccirillo, J. F. & Lu, C. & 2 others, Rodebaugh, T. L. & Ray, W. Z., Mar 1 2023, In: Neurosurgery. 92, 3, p. 538-546 9 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

First-in-human prospective trial of sonobiopsy in high-grade glioma patients using neuronavigation-guided focused ultrasound

Yuan, J., Xu, L., Chien, C. Y., Yang, Y., Yue, Y., Fadera, S., Stark, A. H., Schwetye, K. E., Nazeri, A., Desai, R., Athiraman, U., Chaudhuri, A. A., Chen, H. & Leuthardt, E. C., Dec 2023, In: npj Precision Oncology. 7, 1, 92.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Focused Ultrasound–mediated Liquid Biopsy in a Tauopathy Mouse Model

Pacia, C. P., Yuan, J., Yue, Y., Leuthardt, E. C., Benzinger, T. L. S., Nazeri, A. & Chen, H., Apr 2023, In: Radiology. 307, 2, e220869.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Glioblastoma induces whole-brain spectral change in resting state fMRI: Associations with clinical comorbidities and overall survival

Park, K. Y., Snyder, A. Z., Olufawo, M., Trevino, G., Luckett, P. H., Lamichhane, B., Xie, T., Lee, J. J., Shimony, J. S. & Leuthardt, E. C., Jan 2023, In: NeuroImage: Clinical. 39, 103476.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

High gamma coherence between task-responsive sensory-motor cortical regions in a motor reaction-time task

Anand, S., Cho, H., Adamek, M., Burton, H., Moran, D., Leuthardt, E. & Brunner, P., Sep 2023, In: Journal of neurophysiology. 130, 3, p. 628-639 12 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Individualized precision targeting of dorsal attention and default mode networks with rTMS in traumatic brain injury-associated depression

Siddiqi, S. H., Kandala, S., Hacker, C. D., Trapp, N. T., Leuthardt, E. C., Carter, A. & Brody, D. L., Dec 2023, In: Scientific reports. 13, 1, 4052.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Precision functional MRI mapping reveals distinct connectivity patterns for depression associated with traumatic brain injury

Siddiqi, S. H., Kandala, S., Hacker, C. D., Bouchard, H., Leuthardt, E. C., Corbetta, M., Morey, R. A. & Brody, D. L., 2023, In: Science translational medicine. 15, 703, eabn0441.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Predicting survival in glioblastoma with multimodal neuroimaging and machine learning

Luckett, P. H., Olufawo, M., Lamichhane, B., Park, K. Y., Dierker, D., Verastegui, G. T., Yang, P., Kim, A. H., Chheda, M. G., Snyder, A. Z., Shimony, J. S. & Leuthardt, E. C., Sep 2023, In: Journal of Neuro-Oncology. 164, 2, p. 309-320 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Resting state network mapping in individuals using deep learning

Luckett, P. H., Lee, J. J., Park, K. Y., Raut, R. V., Meeker, K. L., Gordon, E. M., Snyder, A. Z., Ances, B. M., Leuthardt, E. C. & Shimony, J. S., Jan 12 2023, In: Frontiers in Neurology. 13, 1055437.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Single-pulse electrical stimulation artifact removal using the novel matching pursuit-based artifact reconstruction and removal method (MPARRM)

Xie, T., Foutz, T. J., Adamek, M., Swift, J. R., Inman, C. S., Manns, J. R., Leuthardt, E. C., Willie, J. T. & Brunner, P., Dec 1 2023, In: Journal of Neural Engineering. 20, 6, 066036.

Research output: Contribution to journal › Article › peer-review

Open Access

Slow-wave modulation analysis during states of unconsciousness using the novel tau-modulation method

Xie, T., Wu, Z., Foutz, T. J., Sheng, X., Zhu, X., Leuthardt, E. C., Willie, J. T., Chen, L. & Brunner, P., Aug 1 2023, In: Journal of Neural Engineering. 20, 4, 046013.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Structural gray matter alterations in glioblastoma and high-grade glioma - A potential biomarker of survival

Lamichhane, B., Luckett, P. H., Dierker, D., Yun Park, K., Burton, H., Olufawo, M., Trevino, G., Lee, J., Daniel, A. G. S., Hacker, C. D., Marcus, D. S., Shimony, J. S. & Leuthardt, E. C., Jan 1 2023, In: Neuro-Oncology Advances. 5, 1, vdad034.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

The Conventional Dendritic Cell 1 Subset Primes CD8⁺ T Cells and Traffics Tumor Antigen to Drive Antitumor Immunity in the Brain

Bowman-Kirigin, J. A., Desai, R., Saunders, B. T., Wang, A. Z., Schaettler, M. O., Liu, C. J., Livingstone, A. J., Kobayashi, D. K., Durai, V., Kretzer, N. M., Zipfel, G. J., Leuthardt, E. C., Osbun, J. W., Chicoine, M. R., Kim, A. H., Murphy, K. M., Johanns, T. M., Zinselmeyer, B. H. & Dunn, G. P., Jan 1 2023, In: Cancer immunology research. 11, 1, p. 20-27 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Transcranial focused ultrasound-induced blood‒brain barrier opening in mice without shaving hairs

Xu, L., Gong, Y., Chien, C. Y., Leuthardt, E. & Chen, H., Dec 2023, In: Scientific reports. 13, 1, 13500.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2022

Characterization of the Genomic and Immunologic Diversity of Malignant Brain Tumors through Multisector Analysis

Schaettler, M. O., Richters, M. M., Wang, A. Z., Skidmore, Z. L., Fisk, B., Miller, K. E., Vickery, T. L., Kim, A. H., Chicoine, M. R., Osbun, J. W., Leuthardt, E. C., Dowling, J. L., Zipfel, G. J., Dacey, R. G., Lu, H. C., Johanns, T. M., Griffith, O. L., Mardis, E. R., Griffith, M. & Dunn, G. P., Jan 2022, In: Cancer discovery. 12, 1, p. 154-171 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

Combination laser interstitial thermal therapy plus stereotactic radiotherapy increases time to progression for biopsy-proven recurrent brain metastases

Grabowski, M. M., Srinivasan, E. S., Vaios, E. J., Sankey, E. W., Otvos, B., Krivosheya, D., Scott, A., Olufawo, M., Ma, J., Fomchenko, E. I., Herndon, J. E., Kim, A. H., Chiang, V. L., Chen, C. C., Leuthardt, E. C., Barnett, G. H., Kirkpatrick, J. P., Mohammadi, A. M. & Fecci, P. E., Jan 1 2022, In: Neuro-Oncology Advances. 4, 1, vdac086.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Deep learning resting state functional magnetic resonance imaging lateralization of temporal lobe epilepsy

Luckett, P. H., Maccotta, L., Lee, J. J., Park, K. Y., U. F. Dosenbach, N., Ances, B. M., Hogan, R. E., Shimony, J. S. & Leuthardt, E. C., Jun 2022, In: Epilepsia. 63, 6, p. 1542-1552 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Efficacy of laser interstitial thermal therapy (LITT) for newly diagnosed and recurrent IDH wild-type glioblastoma

De Groot, J. F., Kim, A. H., Prabhu, S., Rao, G., Laxton, A. W., Fecci, P. E., O'Brien, B. J., Sloan, A., Chiang, V., Tatter, S. B., Mohammadi, A. M., Placantonakis, D. G., Strowd, R. E., Chen, C., Hadjipanayis, C., Khasraw, M., Sun, D., Piccioni, D., Sinicrope, K. D. & Campian, J. L. & 5 others, Kurz, S. C., Williams, B., Smith, K., Tovar-Spinoza, Z. & Leuthardt, E. C., Jan 1 2022, In: Neuro-Oncology Advances. 4, 1, vdac040.

Research output: Contribution to journal › Article › peer-review

Open Access

52 Scopus citations

Laser Interstitial Thermal Therapy in Grade 2/3 IDH1/2 Mutant Gliomas: A Preliminary Report and Literature Review

Johnson, G. W., Han, R. H., Smyth, M. D., Leuthardt, E. C. & Kim, A. H., Apr 2022, In: Current Oncology. 29, 4, p. 2550-2563 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Making Meaningful Use of Price Transparency Data: Describing Price Variation of Spine Surgery and Imaging in a Single System

Olufawo, M. O., Evans, S. S., Stecher, P. T., Youkilis, S. L., Dibble, C. F., Greenberg, J. K., Ray, W. Z., Hamilton, B. H. & Leuthardt, E. C., Sep 1 2022, In: Neurosurgery. 91, 3, p. E88-E94

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Motor Network Reorganization Induced in Chronic Stroke Patients with the Use of a Contralesionally-Controlled Brain Computer Interface

Humphries, J. B., Mattos, D. J. S., Rutlin, J., Daniel, A. G. S., Rybczynski, K., Notestine, T., Shimony, J. S., Burton, H., Carter, A. & Leuthardt, E. C., 2022, In: Brain-Computer Interfaces. 9, 3, p. 179-192 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Multivariate analysis of associations between clinical sequencing and outcome in glioblastoma

Yang, P. H., Tao, Y., Luo, J., Paturu, M., Lu, H. C., Ramkissoon, S., Heusel, J. W., Leuthardt, E. C., Chicoine, M. R., Dowling, J. L., Dunn, G. P., Duncavage, E., Dahiya, S., Chattherjee, A. R. & Kim, A. H., Jan 1 2022, In: Neuro-Oncology Advances. 4, 1, vdac002.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Neoadjuvant stereotactic radiosurgery for brain metastases: a new paradigm

Li, Y. D., Coxon, A. T., Huang, J., Abraham, C., Dowling, J., Leuthardt, E. C., Dunn, G., Kim, A., Dacey, R. G., Zipfel, G. J., Evans, J., Filiput, E. A. & Chicoine, M., 2022, In: Neurosurgical focus. 53, 5, E8.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Prolonged response of recurrent IDH-wild-type glioblastoma to laser interstitial thermal therapy with pembrolizumab

Hwang, H., Huang, J., Khaddour, K., Butt, O. H., Ansstas, G., Chen, J., Katumba, R. G. N., Kim, A. H., Leuthardt, E. C. & Campian, J. L., Mar 2022, In: CNS oncology. 11, 1, CNS81.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Relief of chronic pain associated with increase in midline frontal theta power

Rustamov, N., Wilson, E. A., Fogarty, A. E., Crock, L. W., Leuthardt, E. C. & Haroutounian, S., Nov 10 2022, In: Pain Reports. 7, 6, p. E1040

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Single-cell profiling of human dura and meningioma reveals cellular meningeal landscape and insights into meningioma immune response

Wang, A. Z., Bowman-Kirigin, J. A., Desai, R., Kang, L. I., Patel, P. R., Patel, B., Khan, S. M., Bender, D., Marlin, M. C., Liu, J., Osbun, J. W., Leuthardt, E. C., Chicoine, M. R., Dacey, R. G., Zipfel, G. J., Kim, A. H., DeNardo, D. G., Petti, A. A. & Dunn, G. P., Dec 2022, In: Genome medicine. 14, 1, 49.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Scopus citations

Sonobiopsy for minimally invasive, spatiotemporally-controlled, and sensitive detection of glioblastoma-derived circulating tumor DNA

Pacia, C. P., Yuan, J., Yue, Y., Xu, L., Nazeri, A., Desai, R., Gach, H. M., Wang, X., Talcott, M. R., Chaudhuri, A. A., Dunn, G. P., Leuthardt, E. C. & Chen, H., 2022, In: Theranostics. 27, 1, p. 362-378 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

Survival After Resection of Newly-Diagnosed Intracranial Grade II Ependymomas: An Initial Multicenter Analysis and the Logistics of Intraoperative Magnetic Resonance Imaging

Yahanda, A. T., Rich, K. M., Dacey, R. G., Zipfel, G. J., Dunn, G. P., Dowling, J. L., Smyth, M. D., Leuthardt, E. C., Limbrick, D. D., Honeycutt, J., Sutherland, G. R., Jensen, R. L., Evans, J. & Chicoine, M. R., Nov 2022, In: World neurosurgery. 167, p. e757-e769

Research output: Contribution to journal › Article › peer-review