We are interested in the biochemistry and biophysics of protein-DNA interactions. In particular, we strive to understand the physical mechanisms of transcription initiation and DNA repair. We use a variety of techniques to investigate the molecular interactions between RNA polymerases, DNA translocases, DNA helicases, and transcription factors that underlie essential processes in biology. Current work in the lab is focused on the following:

1. The mechanisms and outcomes of gene regulation in Mycobacterium tuberculosis (Mtb)
2. The activation of Mtb DNA helicases and their roles in different pathways of DNA repair.
3. The mechanisms of basal transcription initiation in Eukaryotes.
4. The biophysics of viral RNA compaction

• Lab Website

I believe in supporting all members of my laboratory, the program, the division, and the school. The scientific pursuit, today and tomorrow, depends on thoughtful and active student mentorship. This includes training in the scientific method itself, as well as the more technical aspects of research. I know from experience that different students often benefit from different kinds of support and try to adapt my mentoring style accordingly. <br><br>I recognize that systematic racism and sexism has resulted in a lack of diversity in scientific endeavors. Due to the systemic nature of the issue, the active engagement of all those placed in leadership roles within science is needed. Along these lines, I pledge to push the systems in which I participate including my lab, my department, my graduate program, and my university towards a more just and representative distribution of our broader community.

Co-director, DBBS - Biochemistry, Biophysics, and Structural Biology Program

Course-master of Bio458 - Nucleic Acids and Protein Biosynthesis