Research Output per year
Research Output per year
Personal profile
Research interests
We strive to understand the physical mechanisms of transcription initiation and other important DNA-protein interactions. More specifically, we use a variety of single-molecule and bulk biophysical techniques including both optical and magnetic tweezers and fluorescent microscopy to investigate how the assembly of initiation complexes on DNA promoters lead to transcription of genes. Our work is currently focused on the mechanisms of basal transcription initiation in Eukaryotes and on factor-regulated transcription in Mycobacterium tuberculosis.
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Dive into the research topics where Eric Galburt is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Research Output
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CarD and RbpA modify the kinetics of initial transcription and slow promoter escape of the Mycobacterium tuberculosis RNA polymerase
Jensen, D., Manzano, A. R., Rammohan, J., Stallings, C. L. & Galburt, E. A., Jul 26 2019, In : Nucleic acids research. 47, 13, p. 6685-6698 14 p.Research output: Contribution to journal › Article
Open Access7 Scopus citations -
CarD contributes to diverse gene expression outcomes throughout the genome of Mycobacterium tuberculosis
Zhu, D. X., Garner, A. L., Galburt, E. A. & Stallings, C. L., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 27, p. 13573-13581 9 p.Research output: Contribution to journal › Article
Open Access5 Scopus citations -
Single-molecule approach for studying RNAP II transcription initiation using magnetic tweezers
Tomko, E. J. & Galburt, E. A., Apr 15 2019, In : Methods. 159-160, p. 35-44 10 p.Research output: Contribution to journal › Article
2 Scopus citations -
Domains within RbpA serve specific functional roles that regulate the expression of distinct mycobacterial gene subsets
Prusa, J., Jensen, D., Santiago-Collazo, G., Pope, S. S., Garner, A. L., Miller, J. J., Manzano, A. R., Galburt, E. A. & Stallings, C. L., Jul 1 2018, In : Journal of bacteriology. 200, 13, e00690-17.Research output: Contribution to journal › Article
Open Access4 Scopus citations -
The calculation of transcript flux ratios reveals single regulatory mechanisms capable of activation and repression
Galburt, E. A., Dec 11 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 50, p. E11604-E11613Research output: Contribution to journal › Article
6 Scopus citations