Research output per year
Research output per year
Personal profile
Research interests
We strive to understand the physical mechanisms of transcription initiation and other important DNA-protein interactions. More specifically, we use a variety of single-molecule and bulk biophysical techniques including both optical and magnetic tweezers and fluorescent microscopy to investigate how the assembly of initiation complexes on DNA promoters lead to transcription of genes. Our work is currently focused on the mechanisms of basal transcription initiation in Eukaryotes and on factor-regulated transcription in Mycobacterium tuberculosis.
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Molecular dissection of RbpA-mediated regulation of fidaxomicin sensitivity in mycobacteria
Prusa, J., Zhu, D. X., Flynn, A. J., Jensen, D., Manzano, A. R., Galburt, E. A. & Stallings, C. L., Apr 1 2022, In: Journal of Biological Chemistry. 298, 4, 101752.Research output: Contribution to journal › Article › peer-review
Open Access -
Mycobacterium tuberculosis DNA repair helicase UvrD1 is activated by redox-dependent dimerization via a 2B domain cysteine
Chadda, A., Jensen, D., Tomko, E. J., Manzano, A. R., Nguyen, B., Lohman, T. M. & Galburt, E. A., Feb 22 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 8, e2114501119.Research output: Contribution to journal › Article › peer-review
Open Access -
Parallel path mechanisms lead to nonmonotonic force-velocity curves and an optimum load for molecular motor function
Mallimadugula, U. L. & Galburt, E. A., Mar 2022, In: Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 105, 3, 034405.Research output: Contribution to journal › Article › peer-review
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The context-dependent influence of promoter sequence motifs on transcription initiation kinetics and regulation
Jensen, D. & Galburt, E. A., Apr 2021, In: Journal of bacteriology. 203, 8, e00512-20.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
The Role of XPB/Ssl2 dsDNA Translocase Processivity in Transcription Start-site Scanning
Tomko, E. J., Luyties, O., Rimel, J. K., Tsai, C. L., Fuss, J. O., Fishburn, J., Hahn, S., Tsutakawa, S. E., Taatjes, D. J. & Galburt, E. A., Jul 9 2021, In: Journal of Molecular Biology. 433, 14, 166813.Research output: Contribution to journal › Article › peer-review
6 Scopus citations