We are interested in the biochemistry and biophysics of protein-DNA interactions. In particular, we strive to understand the physical mechanisms of transcription regulation and DNA repair. We use a variety of techniques to investigate the molecular interactions of RNA polymerases, DNA translocases, DNA helicases, and transcription factors that underlie these essential processes in biology. Current work in the lab is focused on the following:

1. The mechanisms and outcomes of gene regulation in Mycobacterium tuberculosis (Mtb).
2. The activation of Mtb DNA helicases and their roles in different pathways of DNA repair

• Lab Website

The scientific enterprise depends on thoughtful and active mentorship. This includes training in the scientific method itself as well as the more technical aspects of research. I know from experience that different students often benefit from different kinds of support and try to adapt my mentoring style accordingly.

My mentees have included high school students through the Young Scientist Program, undergraduates through the SURGE program in my department, PhD graduate students through the Biochemistry, Biophysics, and Structural Biology program within DBBS, postdocs, and junior faculty colleagues. 

Co-director, DBBS - Biochemistry, Biophysics, and Structural Biology Program

Course-master of Bio458 - Nucleic Acids and Protein Biosynthesis