Elaine Majerus

Professor of Medicine, Professor of Cell Biology and Physiology

    • Source: Scopus
    1990 …2017

    Research output per year

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    Research interests

    My work is focused on understanding the etiologies of thrombotic microangiopathies to effect a treatment. We have studied the structure function relationship of von Willebrand Factor and ADAMTS13. Deficiency of ADAMTS13 activity leads to a thrombotic microangiopathy. We have identified a small polypeptide of ADAMTS13 that will enhance cleavage of von Willebrand Factor by full-length ADAMTS13. We have also participated in the clinical trials of eculizumab in the treatment of atypical hemolytic uremic syndrome, another thrombotic microangiopathy that results from deficient complement regulation.

    Areas of Clinical Interest

    Blood disorders, hemophilia and bleeding disorders, disorders of blood-forming tissues, hemostasis, thrombosis, hematology, cardiovascular metabolic research; platelets and coagulation factors

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