Elaine Majerus

Professor of Medicine, Co-Division Chief - Division of Hematology, Professor of Cell Biology and Physiology

    • 1860
    1990 …2024

    Research activity per year

    Personal profile

    Research interests

    My work is focused on understanding the etiologies of thrombotic microangiopathies to effect a treatment. We have studied the structure function relationship of von Willebrand Factor and ADAMTS13. Deficiency of ADAMTS13 activity leads to a thrombotic microangiopathy. We have identified a small polypeptide of ADAMTS13 that will enhance cleavage of von Willebrand Factor by full-length ADAMTS13. We have also participated in the clinical trials of eculizumab in the treatment of atypical hemolytic uremic syndrome, another thrombotic microangiopathy that results from deficient complement regulation.

    Clinical interests

    Blood disorders, hemophilia and bleeding disorders, disorders of blood-forming tissues, hemostasis, thrombosis, hematology, cardiovascular metabolic research; platelets and coagulation factors


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