Elaine Majerus

Professor of Medicine, Professor of Cell Biology and Physiology

    • 1583 Citations
    1990 …2017

    Research output per year

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    Personal profile

    Research interests

    My work is focused on understanding the etiologies of thrombotic microangiopathies to effect a treatment. We have studied the structure function relationship of von Willebrand Factor and ADAMTS13. Deficiency of ADAMTS13 activity leads to a thrombotic microangiopathy. We have identified a small polypeptide of ADAMTS13 that will enhance cleavage of von Willebrand Factor by full-length ADAMTS13. We have also participated in the clinical trials of eculizumab in the treatment of atypical hemolytic uremic syndrome, another thrombotic microangiopathy that results from deficient complement regulation.

    Areas of Clinical Interest

    Blood disorders, hemophilia and bleeding disorders, disorders of blood-forming tissues, hemostasis, thrombosis, hematology, cardiovascular metabolic research; platelets and coagulation factors

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    Research Output

    • 1583 Citations
    • 17 Article
    • 2 Comment/debate
    • 1 Conference contribution
    • 1 Review article
    Open Access
  • NNKTT120, an anti-iNKT cell monoclonal antibody, produces rapid and sustained iNKT cell depletion in adults with sickle cell disease

    Field, J. J., Majerus, E., Ataga, K. I., Vichinsky, E. P., Schaub, R., Mashal, R. & Nathan, D. G., Feb 2017, In : PloS one. 12, 2, 0171067.

    Research output: Contribution to journalArticle

    Open Access
  • 17 Scopus citations

    Randomized phase 2 trial of regadenoson for treatment of acute vaso-occlusive crises in sickle cell disease

    Field, J. J., Majerus, E., Gordeuk, V. R., Gowhari, M., Hoppe, C., Heeney, M. M., Achebe, M., George, A., Chu, H., Sheehan, B., Puligandla, M., Neuberg, D., Lin, G., Linden, J. & Nathan, D. G., Sep 12 2017, In : Blood Advances. 1, 20, p. 1645-1649 5 p.

    Research output: Contribution to journalArticle

    Open Access
  • 22 Scopus citations

    Peters plus syndrome mutations disrupt a noncanonical ER quality-control mechanism

    Vasudevan, D., Takeuchi, H., Johar, S. S., Majerus, E. & Haltiwanger, R. S., Feb 2 2015, In : Current Biology. 25, 3, p. 286-295 10 p.

    Research output: Contribution to journalArticle

    Open Access
  • 45 Scopus citations

    After the treated mole

    Rashidi, A. & Majerus, E. M., May 1 2014, In : Blood. 123, 18, 1 p.

    Research output: Contribution to journalComment/debate

    Open Access