Personal profile
Research interests
I study the mechanisms of TDP-43 aggregate pathology, primarily in myopathy. My current focus is on the prion-like aggregate seeding that occurs in both myopathy patients and neurodegenerative patients with TDP-43 pathology. I am interested in characterizing similarities and differences in TDP-43 pathological mechanisms between the two tissue types and whether it is possible for TDP-43 aggregate seeds to spread between tissues.
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Collaborations and top research areas from the last five years
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Seeding-competent TDP-43 persists in human patient and mouse muscle
Lynch, E. M., Pittman, S., Daw, J., Ikenaga, C., Chen, S., Dhavale, D. D., Jackrel, M. E., Ayala, Y. M., Kotzbauer, P., Ly, C. V., Pestronk, A., Lloyd, T. E. & Weihl, C. C., Nov 27 2024, In: Science translational medicine. 16, 775, eadp5730.Research output: Contribution to journal › Article › peer-review
Open Access14 Link opens in a new tab Scopus citations -
Current Progress in the Creation, Characterization, and Application of Human Stem Cell-derived in Vitro Neuromuscular Junction Models
Lynch, E., Peek, E., Reilly, M., FitzGibbons, C., Robertson, S. & Suzuki, M., Feb 2022, In: Stem Cell Reviews and Reports. 18, 2, p. 768-780 13 p.Research output: Contribution to journal › Review article › peer-review
Open Access12 Link opens in a new tab Scopus citations -
Transcriptome analysis using patient iPSC-derived skeletal myocytes: Bet1L as a new molecule possibly linked to neuromuscular junction degeneration in ALS
Lynch, E. M., Robertson, S., FitzGibbons, C., Reilly, M., Switalski, C., Eckardt, A., Tey, S. R., Hayakawa, K. & Suzuki, M., Nov 2021, In: Experimental Neurology. 345, 113815.Research output: Contribution to journal › Article › peer-review
Open Access9 Link opens in a new tab Scopus citations -
C9ORF72-related cellular pathology in skeletal myocytes derived from ALS-patient induced pluripotent stem cells
Lynch, E., Semrad, T., Belsito, V. S., FitzGibbons, C., Reilly, M., Hayakawa, K. & Suzuki, M., 2019, In: DMM Disease Models and Mechanisms. 12, 8, dmm039552.Research output: Contribution to journal › Article › peer-review
Open Access32 Link opens in a new tab Scopus citations -
Coding Cell Identity of Human Skeletal Muscle Progenitor Cells Using Cell Surface Markers: Current Status and Remaining Challenges for Characterization and Isolation
Tey, S. R., Robertson, S., Lynch, E. & Suzuki, M., Nov 26 2019, In: Frontiers in Cell and Developmental Biology. 7, 284.Research output: Contribution to journal › Review article › peer-review
Open Access20 Link opens in a new tab Scopus citations