Edward Han

Assistant Professor of Neuroscience, Assistant Professor of Anesthesiology

    • 169 Citations

    Research output per year

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    Personal profile

    Research interests

    The long-term goal of the Han Lab is to understand and manipulate learning in the hippocampus, a brain area that is impaired in many neurodegenerative and cognitive disorders such as Alzheimer’s disease. To accomplish this goal we use advanced optical imaging and electrophysiology methods to study neuronal activity in awake, behaving animals. One major line of research in the lab is studying learning-related neuronal activity using two-photon calcium imaging in animals performing a virtual reality behavioral task. This innovative approach allows us to probe neural circuit function from the level of proteins, to networks, to behavior, in real-time. A second major line of research is to apply this methodology to investigate the role of toxic protein aggregates associated with Alzheimer’s disease on neuronal health and function.

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    Research Output

    • 169 Citations
    • 5 Article
    • 1 Comment/debate

    Structured inhibitory activity dynamics in new virtual environments

    Arriaga, M. & Han, E. B., Oct 2019, In : eLife. 8

    Research output: Contribution to journalArticle

    Open Access
  • Dedicated hippocampal inhibitory networks for locomotion and immobility

    Arriaga, M. & Han, E. B., Sep 20 2017, In : Journal of Neuroscience. 37, 38, p. 9222-9238 17 p.

    Research output: Contribution to journalArticle

    Open Access
  • 16 Scopus citations

    Distal dendritic inputs control neuronal activity by heterosynaptic potentiation of proximal inputs

    Han, E. B. & Heinemann, S. F., Jan 23 2013, In : Journal of Neuroscience. 33, 4, p. 1314-1325 12 p.

    Research output: Contribution to journalArticle

    Open Access
  • 27 Scopus citations
    Open Access
  • 61 Scopus citations

    Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures

    Kerjan, G., Koizumi, H., Han, E. B., Dubé, C. M., Djakovic, S. N., Patrick, G. N., Baram, T. Z., Heinemann, S. F. & Gleeson, J. G., Apr 21 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 16, p. 6766-6771 6 p.

    Research output: Contribution to journalArticle

    Open Access
  • 60 Scopus citations