Dwight Look

2018

Pseudohypobicarbonatemia in a Patient Presenting with Suspected Diabetic Ketoacidosis

Cartier, J. L., Look, D. C. & Dunn, J., Mar 1 2018, In: AACE Clinical Case Reports. 4, 2, p. 108-111 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2012

Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease

Martinez, C. H., Chen, Y. H., Westgate, P. M., Liu, L. X., Murray, S., Curtis, J. L., Make, B. J., Kazerooni, E. A., Lynch, D. A., Marchetti, N., Washko, G. R., Martinez, F. J., Han, M. L. K., Hanania, N., Alapat, P., Bandi, V., Guntupalli, K., Guy, E., Mallampalli, A. & Trinh, C. & 108 others, Atik, M., DeMeo, D., Hersh, C., Jacobson, F., Barr, R. G., Thomashow, B., Austin, J., MacIntyre, N., Washington, L., McAdams, H. P., Rosiello, R., Bresnahan, T., McEvoy, C., Tashjian, J., Wise, R., Hansel, N., Brown, R., Diette, G., Casaburi, R., Porszasz, J., Fischer, H., Budoff, M., DeBakey, M. E., Sharafkhaneh, A., Kamal, H., Darvishi, R., Niewoehner, D., Allen, T., Anderson, Q., Rice, K., Foreman, M., Westney, G., Berkowitz, E., Bowler, R., Friedlander, A., Schroeder, J., Newell, J., Criner, G., Kim, V., Satti, A., Mamary, A. J., Steiner, R., Dass, C., Bailey, W., Dransfield, M., Nath, H., Ramsdell, J., Friedman, P., McLennan, G., Van Beek, E. J. R., Thompson, B., Look, D., Wendt, C., Sciurba, F., Weissfeld, J., Fuhrman, C., Bon, J., Anzueto, A., Adams, S., Orozco, C., Ruiz, M., Crapo, J., Silverman, E., Regan, E., Moyle, S., Stinson, D., Beaty, T., Klanderman, B., Laird, N., Lange, C., Cho, M., Santorico, S., Hokanson, J., Hetmanski, J., Murray, T., Reilly, J., Coxson, H., Judy, P., Hoffman, E., Estepar, R. S. J., Ross, J., Leek, R., Zach, J., Kluiber, A., Sieren, J., Baumhauer, H., McArthur, V., Kazlouski, D., Allen, A., Mann, T., Rodionova, A., Jensen, R., Farzadegan, H., Meyerer, S., Chandan, S., Bragan, S., Murphy, J., Everett, D., Wilson, C., Knowles, R., Powell, A., Piccoli, J., Robinson, M., Forbes, M., Wamboldt, M., Sontag, M., Black-Shinn, J. & Kinney, G., May 2012, In: Thorax. 67, 5, p. 399-406 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

111 Scopus citations

Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort

Rambod, M., Porszasz, J., Make, B. J., Crapo, J. D., Casaburi, R., Curtis, J., Kazerooni, E., Hanania, N., Alapat, P., Bandi, V., Guntupalli, K., Guy, E., Mallampalli, A., Trinh, C., Al-Azzawi, H., Atik, M., DeMeo, D., Hersh, C., Washko, G. & Jacobson, F. & 108 others, Barr, R. G., Thomashow, B., Austin, J., MacIntyre, N., Washington, L., McAdams, H. P., Rosiello, R., Bresnahan, T., McEvoy, C., Tashjian, J., Wise, R., Hansel, N., Brown, R., Diette, G., Fischer, H., Budoff, M. J., Sharafkhaneh, A., Kamal, H., Darvishi, R., Niewoehner, D., Allen, T., Anderson, Q., Rice, K., Foreman, M., Westney, G., Berkowitz, E., Bowler, R., Friedlander, A., Lynch, D., Schroeder, J., Newell, J., Criner, G., Kim, V., Marchetti, N., Satti, A., Mamary, A. J., Steiner, R., Dass, C., Bailey, W., Dransfield, M., Nath, H., Ramsdell, J., Friedman, P., Look, D., McLennan, G., Van Beek, E. J. R., Thompson, B., Martinez, F., Han, M. L., Wendt, C., Sciurba, F., Weissfeld, J., Fuhrman, C., Bon, J., Anzueto, A., Adams, S., Orozco, C., Ruiz, M., Silverman, E., Regan, E., Moyle, S., Stepp, L., Lantz, R., Beaty, T., Klanderman, B., Laird, N., Lange, C., Cho, M., Santorico, S., Hokanson, J., Hetmanski, J., Murray, T., Reilly, J., Coxson, H., Judy, P., Hoffman, E., Estepar, R. S. J., Ross, J., Leek, R., Zach, J., Kluiber, A., Sieren, J., Baumhauer, H., McArthur, V., Kazlouski, D., Richert, D., Gethin-Jones, T., Allen, A., Mann, T., Rodionova, A., Stinson, D., Jensen, R., Farzadegan, H., Meyerer, S., Chandan, S., Bragan, S., Murphy, J., Everett, D., Wilson, C., Knowles, R., Powell, A., Piccoli, J., Robinson, M., Forbes, M., Wamboldt, M., Sontag, M., Black-Shinn, J. & Kinney, G., Apr 2012, In: CHEST. 141, 4, p. 867-875 9 p.

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

2011

Genome-wide association study of smoking behaviours in patients with COPD

Siedlinski, M., Cho, M. H., Bakke, P., Gulsvik, A., Lomas, D. A., Anderson, W., Kong, X., Rennard, S. I., Beaty, T. H., Hokanson, J. E., Crapo, J. D., Silverman, E. K., Coxson, H., Edwards, L., Knobil, K., MacNee, W., Tal-Singer, R., Vestbo, J., Yates, J. & Curtis, J. & 73 others, Kazerooni, E., Hanania, N., Alapat, P., Bandi, V., Guntupalli, K., Guy, E., Mallampalli, A., Trinh, C., Atik, M., DeMeo, D., Hersh, C., Washko, G., Jacobson, F., Barr, G., Thomashow, B., Austin, J., MacIntyre, N., Washington, L., McAdams, H. P., Rosiello, R., Bresnahan, T., McEvoy, C., Tashjian, J., Wise, R., Hansel, N., Brown, R., Diette, G., Casaburi, R., Porszasz, J., Fischer, H., Budoff, M., Sharafkhaneh, A., Kamal, H., Darvishi, R., Niewoehner, D., Allen, T., Anderson, Q., Rice, K., Foreman, M., Westney, G., Berkowitz, E., Bowler, R., Friedlander, A., Lynch, D., Schroeder, J., Newell, J., Criner, G., Kim, V., Marchetti, N., Satti, A., Mamary, A. J., Steiner, R., Dass, C., Bailey, W., Dransfield, M., Nath, H., Ramsdell, J., Friedman, P., McLennan, G., Van Beek, E. J. R., Thompson, B., Look, D., Martinez, F., Han, M. L., Wendt, C., Sciurba, F., Weissfeld, J., Fuhrman, C., Bon, J., Anzueto, A., Adams, S., Orozco, C. & Ruiz, M., Oct 2011, In: Thorax. 66, 10, p. 894-902 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

93 Scopus citations

Inhibition by cigarette smoke of nuclear factor-κB-dependent response to bacteria in the airway

Manzel, L. J., Shi, L., O'Shaughnessy, P. T., Thorne, P. S. & Look, D. C., Feb 1 2011, In: American Journal of Respiratory Cell and Molecular Biology. 44, 2, p. 155-165 11 p.

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

The clinical features of the overlap between COPD and asthma

COPDGene Investigators, Sep 27 2011, In: Respiratory Research. 12, 1, 127.

Research output: Contribution to journal › Article › peer-review

Open Access

379 Scopus citations

2010

Inhibition of IFN-γ-dependent antiviral airway epithelial defense by cigarette smoke

Modestou, M. A., Manzel, L. J., El-Mahdy, S. & Look, D. C., May 26 2010, In: Respiratory Research. 11, 64.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

2009

Cigarette smoke alters respiratory syncytial virus-induced apoptosis and replication

Groskreutz, D. J., Monick, M. M., Babor, E. C., Nyunoya, T., Varga, S. M., Look, D. C. & Hunninghake, G. W., Aug 1 2009, In: American Journal of Respiratory Cell and Molecular Biology. 41, 2, p. 189-198 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

45 Scopus citations

Differential effects of cytokines and corticosteroids on Toll-like receptor 2 expression and activity in human airway epithelia

Winder, A. A., Wohlford-Lenane, C., Scheetz, T. E., Nardy, B. N., Manzel, L. J., Look, D. C. & McCray, P. B., Oct 16 2009, In: Respiratory Research. 10, 96.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia

Hong, P. J., Look, D. C., Tan, P., Shi, L., Hickey, M., Gakhar, L., Chappell, M. C., Wohlford-Lenane, C. & McCray, P. B., Jul 2009, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 297, 1, p. L84-L96

Research output: Contribution to journal › Article › peer-review

Open Access

278 Scopus citations

Regulation of bacteria-induced intercellular adhesion molecule-1 by CCAAT/enhancer binding proteins

Manzel, L. J., Chin, C. L., Behlke, M. A. & Look, D. C., Feb 1 2009, In: American Journal of Respiratory Cell and Molecular Biology. 40, 2, p. 200-210 11 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

2008

Respiratory epithelial cells convert inactive vitamin D to its active form: Potential effects on host defense

Hansdottir, S., Monick, M. M., Hinde, S. L., Lovan, N., Look, D. C. & Hunninghake, G. W., Nov 15 2008, In: Journal of Immunology. 181, 10, p. 7090-7099 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

501 Scopus citations

Serial isolates of persistent Haemophilus influenzae in patients with chronic obstructive pulmonary disease express diminishing quantities of the HMW1 and HMW2 adhesins

Cholon, D. M., Cutter, D., Richardson, S. K., Sethi, S., Murphy, T. F., Look, D. C. & St. Geme, J. W., Oct 2008, In: Infection and immunity. 76, 10, p. 4463-4468 6 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

2007

Human adenovirus modulates surfactant phospholipid trafficking

Miakotina, O. L., McCoy, D. M., Shi, L., Look, D. C. & Mallampalli, R. K., Dec 2007, In: Traffic. 8, 12, p. 1765-1777 13 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Increased arylsulfatase B activity in cystic fibrosis cells following correction of CFTR

Bhattacharyya, S., Look, D. & Tobacman, J. K., May 1 2007, In: Clinica Chimica Acta. 380, 1-2, p. 122-127 6 p.

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Inhibition of Jak1-dependent signal transduction in airway epithelial cells infected with adenovirus

Shi, L., Ramaswamy, M., Manzel, L. J. & Look, D. C., Dec 2007, In: American Journal of Respiratory Cell and Molecular Biology. 37, 6, p. 720-728 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus

McCray, P. B., Pewe, L., Wohlford-Lenane, C., Hickey, M., Manzel, L., Shi, L., Netland, J., Jia, H. P., Halabi, C., Sigmund, C. D., Meyerholz, D. K., Kirby, P., Look, D. C. & Perlman, S., Jan 2007, In: Journal of virology. 81, 2, p. 813-821 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

773 Scopus citations

Nonstructural proteins of respiratory syncytial virus suppress premature apoptosis by an NF-κB-dependent, interferon-independent mechanism and facilitate virus growth

Bitko, V., Shulyayeva, O., Mazumder, B., Musiyenko, A., Ramaswamy, M., Look, D. C. & Barik, S., Feb 2007, In: Journal of virology. 81, 4, p. 1786-1795 10 p.

Research output: Contribution to journal › Article › peer-review

145 Scopus citations

Paracellular permeability restricts airway epithelial responses to selectively allow activation by mediators at the basolateral surface

Humlicek, A. L., Manzel, L. J., Chin, C. L., Shi, L., Excoffon, K. J. D. A., Winter, M. C., Shasby, D. M. & Look, D. C., May 15 2007, In: Journal of Immunology. 178, 10, p. 6395-6403 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

Respiratory syncytial virus decreases p53 protein to prolong survival of airway epithelial cells

Groskreutz, D. J., Monick, M. M., Yarovinsky, T. O., Powers, L. S., Quelle, D. E., Varga, S. M., Look, D. C. & Hunninghake, G. W., Sep 1 2007, In: Journal of Immunology. 179, 5, p. 2741-2747 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

61 Scopus citations

2006

Modulation of airway inflammation by Haemophilus influenzae isolates associated with chronic obstructive pulmonary disease exacerbation

Look, D. C., Chin, C. L., Manzel, L. J., Lehman, E. E., Humlicek, A. L., Shi, L., Starner, T. D., Denning, G. M., Murphy, T. F. & Sethi, S., 2006, In: Proceedings of the American Thoracic Society. 3, 6, p. 482-483 2 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Respiratory syncytial virus induces TLR3 protein and protein kinase R, leading to increased double-stranded RNA responsiveness in airway epithelial cells

Groskreutz, D. J., Monick, M. M., Powers, L. S., Yarovinsky, T. O., Look, D. C. & Hunninghake, G. W., Feb 1 2006, In: Journal of Immunology. 176, 3, p. 1733-1740 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

220 Scopus citations

Respiratory syncytial virus nonstructural protein 2 specifically inhibits type I interferon signal transduction

Ramaswamy, M., Shi, L., Varga, S. M., Barik, S., Behlke, M. A. & Look, D. C., Jan 20 2006, In: Virology. 344, 2, p. 328-339 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

138 Scopus citations

2005

ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia

Jia, H. P., Look, D. C., Shi, L., Hickey, M., Pewe, L., Netland, J., Farzan, M., Wohlford-Lenane, C., Perlman, S. & McCray, P. B., Dec 2005, In: Journal of virology. 79, 23, p. 14614-14621 8 p.

Research output: Contribution to journal › Article › peer-review

681 Scopus citations

Adenovirus stimulates choline efflux by increasing expression of organic cation transporter-2

Miakotina, O. L., Agassandian, M., Shi, L., Look, D. C. & Mallampalli, R. K., Jan 2005, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 288, 1 32-1, p. L93-L102

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

A severe acute respiratory syndrome-associated coronavirus-specific protein enhances virulence of an attenuated murine coronavirus

Pewe, L., Zhou, H., Netland, J., Tangudu, C., Olivares, H., Shi, L., Look, D., Gallagher, T. & Perlman, S., Sep 2005, In: Journal of virology. 79, 17, p. 11335-11342 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

85 Scopus citations

Haemophilus influenzae from patients with chronic obstructive pulmonary disease exacerbation induce more inflammation than colonizers

Chin, C. L., Manzel, L. J., Lehman, E. E., Humlicek, A. L., Shi, L., Starner, T. D., Denning, G. M., Murphy, T. F., Sethi, S. & Look, D. C., Jul 1 2005, In: American journal of respiratory and critical care medicine. 172, 1, p. 85-91 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

134 Scopus citations

NF-κB activation and sustained IL-8 gene expression in primary cultures of cystic fibrosis airway epithelial cells stimulated with Pseudomonas aeruginosa

Joseph, T., Look, D. & Ferkol, T., Mar 2005, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 288, 3 32-3, p. L471-L479

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

Pyocyanin and its precursor phenazine-1-carboxylic acid increase IL-8 and intercellular adhesion molecule-1 expression in human airway epithelial cells by oxidant-dependent mechanisms

Look, D. C., Stoll, L. L., Romig, S. A., Humlicek, A., Britigan, B. E. & Denning, G. M., Sep 15 2005, In: Journal of Immunology. 175, 6, p. 4017-4023 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

62 Scopus citations

2004

Modulation of airway inflammation and bacterial clearance by epithelial cell ICAM-1

Humlicek, A. L., Pang, L. & Look, D. C., Sep 2004, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 287, 3 31-3, p. L598-L607

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Specific inhibition of type I interferon signal transduction by respiratory syncytial virus

Ramaswamy, M., Shi, L., Monick, M. M., Hunninghake, G. W. & Look, D. C., Jun 2004, In: American Journal of Respiratory Cell and Molecular Biology. 30, 6, p. 893-900 8 p.

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

2002

Inflammatory response in airway epithelial cells isolated from patients with cystic fibrosis

Aldallal, N., McNaughton, E. E., Manzel, L. J., Richards, A. M., Zabner, J., Ferkol, T. W. & Look, D. C., Nov 1 2002, In: American journal of respiratory and critical care medicine. 166, 9, p. 1248-1256 9 p.

Research output: Contribution to journal › Article › peer-review

109 Scopus citations

2001

Effects of paramyxoviral infection on airway epithelial cell foxj1 expression, ciliogenesis, and mucociliary function

Look, D. C., Walter, M. J., Williamson, M. R., Pang, L., You, Y., Sreshta, J. N., Johnson, J. E., Zander, D. S. & Brody, S. L., Dec 2001, In: American Journal of Pathology. 159, 6, p. 2055-2069 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

75 Scopus citations

Specific Inhibition of Interferon Signal Transduction Pathways by Adenoviral Infection

Joseph, T. D. & Look, D. C., Dec 14 2001, In: Journal of Biological Chemistry. 276, 50, p. 47136-47142 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

2000

Haemophilus influenzae stimulates ICAM-1 expression on respiratory epithelial cells

Frick, A. G., Joseph, T. D., Pang, L., Rabe, A. M., St. Geme, J. W. & Look, D. C., Apr 15 2000, In: Journal of Immunology. 164, 8, p. 4185-4196 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

90 Scopus citations

The osmolyte xylitol reduces the salt concentration of airway surface liquid and may enhance bacterial killing

Zabner, J., Seiler, M. P., Launspach, J. L., Karp, P. H., Kearney, W. R., Look, D. C., Smith, J. J. & Welsh, M. J., Oct 10 2000, In: Proceedings of the National Academy of Sciences of the United States of America. 97, 21, p. 11614-11619 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

108 Scopus citations

1999

Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma

Sampath, D., Castro, M., Look, D. C. & Holtzman, M. J., May 1999, In: Journal of Clinical Investigation. 103, 9, p. 1353-1361 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

205 Scopus citations

Virus-inducible expression of a host chemokine gene relies on replication-linked mRNA stabilization

Koga, T., Sardiña, E., Tidwell, R. M., Pelletier, M., Look, D. C. & Holtzman, M. J., May 11 1999, In: Proceedings of the National Academy of Sciences of the United States of America. 96, 10, p. 5680-5685 6 p.

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

1998

Direct suppression of Stat1 function during adenoviral infection

Look, D. C., Roswit, W. T., Frick, A. G., Gris-Alevy, Y., Dickhaus, D. M., Walter, M. J. & Holtzman, M. J., Dec 1998, In: Immunity. 9, 6, p. 871-880 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

142 Scopus citations

Patterns for RANTES secretion and intercellular adhesion molecule 1 expression mediate transepithelial T cell traffic based on analyses in vitro and in vivo

Taguchi, M., Sampath, D., Koga, T., Castro, M., Look, D. C., Nakajima, S. & Holtzman, M. J., Jun 15 1998, In: Journal of Experimental Medicine. 187, 12, p. 1927-1940 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

82 Scopus citations

1997

Targeted inhibition of interferon-γ-dependent intercellular adhesion molecule-1 (ICAM-1) expression using dominant-negative Stat1

Walter, M. J., Look, D. C., Tidwell, R. M., Roswit, W. T. & Holtzman, M. J., Nov 7 1997, In: Journal of Biological Chemistry. 272, 45, p. 28582-28589 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

86 Scopus citations

1996

STAT-1 and SP1 interact to synergistically activate ICAM-1 gene transcription

Look, D., Pelletier, M., Tidwell, R., Roswit, W. & Hfiltzmm, M., Dec 1 1996, In: FASEB Journal. 10, 6, p. A1516

Research output: Contribution to journal › Article › peer-review

1995

A hierarchy for integrin expression and adhesiveness among T cell subsets that is linked to TCR gene usage and emphasizes Vδ1⁺ γδ T cell adherence and tissue retention

Nakajima, S., Roswit, W. T., Look, D. C. & Holtzman, M. J., 1995, In: Journal of Immunology. 155, 3, p. 1117-1131 15 p.

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Stat1 depends on transcriptional synergy with Sp1

Look, D. C., Pelletier, M. B., Tidwell, R. M., Roswit, W. T. & Holtzman, M. J., Dec 22 1995, In: Journal of Biological Chemistry. 270, 51, p. 30264-30267 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access