Dwight Look

Research output

Research output per year 1992 2005 2006 2007 2009 2018

• 47 Article
• 6 Review article
• 2 Conference contribution
• 1 Comment/debate
• 1 More
  • 1 Short survey

Research output per year

Research output per year

Search results

• 2018

  Pseudohypobicarbonatemia in a Patient Presenting with Suspected Diabetic Ketoacidosis

  Cartier, J. L., Look, D. C. & Dunn, J., Mar 1 2018, In: AACE Clinical Case Reports. 4, 2, p. 108-111 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Diabetic Ketoacidosis 100%
  • Bicarbonates 85%
  • Blood Gas Analysis 24%
  • Triglycerides 15%
  • Insulin 13%
  5 Scopus citations
• 2012

  Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease

  Martinez, C. H., Chen, Y. H., Westgate, P. M., Liu, L. X., Murray, S., Curtis, J. L., Make, B. J., Kazerooni, E. A., Lynch, D. A., Marchetti, N., Washko, G. R., Martinez, F. J., Han, M. L. K., Hanania, N., Alapat, P., Bandi, V., Guntupalli, K., Guy, E., Mallampalli, A., Trinh, C., & 108 othersAtik, M., DeMeo, D., Hersh, C., Jacobson, F., Barr, R. G., Thomashow, B., Austin, J., MacIntyre, N., Washington, L., McAdams, H. P., Rosiello, R., Bresnahan, T., McEvoy, C., Tashjian, J., Wise, R., Hansel, N., Brown, R., Diette, G., Casaburi, R., Porszasz, J., Fischer, H., Budoff, M., DeBakey, M. E., Sharafkhaneh, A., Kamal, H., Darvishi, R., Niewoehner, D., Allen, T., Anderson, Q., Rice, K., Foreman, M., Westney, G., Berkowitz, E., Bowler, R., Friedlander, A., Schroeder, J., Newell, J., Criner, G., Kim, V., Satti, A., Mamary, A. J., Steiner, R., Dass, C., Bailey, W., Dransfield, M., Nath, H., Ramsdell, J., Friedman, P., McLennan, G., Van Beek, E. J. R., Thompson, B., Look, D., Wendt, C., Sciurba, F., Weissfeld, J., Fuhrman, C., Bon, J., Anzueto, A., Adams, S., Orozco, C., Ruiz, M., Crapo, J., Silverman, E., Regan, E., Moyle, S., Stinson, D., Beaty, T., Klanderman, B., Laird, N., Lange, C., Cho, M., Santorico, S., Hokanson, J., Hetmanski, J., Murray, T., Reilly, J., Coxson, H., Judy, P., Hoffman, E., Estepar, R. S. J., Ross, J., Leek, R., Zach, J., Kluiber, A., Sieren, J., Baumhauer, H., McArthur, V., Kazlouski, D., Allen, A., Mann, T., Rodionova, A., Jensen, R., Farzadegan, H., Meyerer, S., Chandan, S., Bragan, S., Murphy, J., Everett, D., Wilson, C., Knowles, R., Powell, A., Piccoli, J., Robinson, M., Forbes, M., Wamboldt, M., Sontag, M., Black-Shinn, J. & Kinney, G., May 2012, In: Thorax. 67, 5, p. 399-406 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Emphysema 100%
  • Chronic Obstructive Pulmonary Disease 79%
  • Health Status 77%
  • Bronchi 11%
  • Masks 11%
  104 Scopus citations

• Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort

  Rambod, M., Porszasz, J., Make, B. J., Crapo, J. D., Casaburi, R., Curtis, J., Kazerooni, E., Hanania, N., Alapat, P., Bandi, V., Guntupalli, K., Guy, E., Mallampalli, A., Trinh, C., Al-Azzawi, H., Atik, M., DeMeo, D., Hersh, C., Washko, G., Jacobson, F., & 108 othersBarr, R. G., Thomashow, B., Austin, J., MacIntyre, N., Washington, L., McAdams, H. P., Rosiello, R., Bresnahan, T., McEvoy, C., Tashjian, J., Wise, R., Hansel, N., Brown, R., Diette, G., Fischer, H., Budoff, M. J., Sharafkhaneh, A., Kamal, H., Darvishi, R., Niewoehner, D., Allen, T., Anderson, Q., Rice, K., Foreman, M., Westney, G., Berkowitz, E., Bowler, R., Friedlander, A., Lynch, D., Schroeder, J., Newell, J., Criner, G., Kim, V., Marchetti, N., Satti, A., Mamary, A. J., Steiner, R., Dass, C., Bailey, W., Dransfield, M., Nath, H., Ramsdell, J., Friedman, P., Look, D., McLennan, G., Van Beek, E. J. R., Thompson, B., Martinez, F., Han, M. L., Wendt, C., Sciurba, F., Weissfeld, J., Fuhrman, C., Bon, J., Anzueto, A., Adams, S., Orozco, C., Ruiz, M., Silverman, E., Regan, E., Moyle, S., Stepp, L., Lantz, R., Beaty, T., Klanderman, B., Laird, N., Lange, C., Cho, M., Santorico, S., Hokanson, J., Hetmanski, J., Murray, T., Reilly, J., Coxson, H., Judy, P., Hoffman, E., Estepar, R. S. J., Ross, J., Leek, R., Zach, J., Kluiber, A., Sieren, J., Baumhauer, H., McArthur, V., Kazlouski, D., Richert, D., Gethin-Jones, T., Allen, A., Mann, T., Rodionova, A., Stinson, D., Jensen, R., Farzadegan, H., Meyerer, S., Chandan, S., Bragan, S., Murphy, J., Everett, D., Wilson, C., Knowles, R., Powell, A., Piccoli, J., Robinson, M., Forbes, M., Wamboldt, M., Sontag, M., Black-Shinn, J. & Kinney, G., Apr 2012, In: CHEST. 141, 4, p. 867-875 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Emphysema 100%
  • Gases 75%
  • Chronic Obstructive Pulmonary Disease 59%
  • African Americans 41%
  • Lung 35%
  38 Scopus citations
• 2011

  Genome-wide association study of smoking behaviours in patients with COPD

  Siedlinski, M., Cho, M. H., Bakke, P., Gulsvik, A., Lomas, D. A., Anderson, W., Kong, X., Rennard, S. I., Beaty, T. H., Hokanson, J. E., Crapo, J. D., Silverman, E. K., Coxson, H., Edwards, L., Knobil, K., MacNee, W., Tal-Singer, R., Vestbo, J., Yates, J., Curtis, J., & 73 othersKazerooni, E., Hanania, N., Alapat, P., Bandi, V., Guntupalli, K., Guy, E., Mallampalli, A., Trinh, C., Atik, M., DeMeo, D., Hersh, C., Washko, G., Jacobson, F., Barr, G., Thomashow, B., Austin, J., MacIntyre, N., Washington, L., McAdams, H. P., Rosiello, R., Bresnahan, T., McEvoy, C., Tashjian, J., Wise, R., Hansel, N., Brown, R., Diette, G., Casaburi, R., Porszasz, J., Fischer, H., Budoff, M., Sharafkhaneh, A., Kamal, H., Darvishi, R., Niewoehner, D., Allen, T., Anderson, Q., Rice, K., Foreman, M., Westney, G., Berkowitz, E., Bowler, R., Friedlander, A., Lynch, D., Schroeder, J., Newell, J., Criner, G., Kim, V., Marchetti, N., Satti, A., Mamary, A. J., Steiner, R., Dass, C., Bailey, W., Dransfield, M., Nath, H., Ramsdell, J., Friedman, P., McLennan, G., Van Beek, E. J. R., Thompson, B., Look, D., Martinez, F., Han, M. L., Wendt, C., Sciurba, F., Weissfeld, J., Fuhrman, C., Bon, J., Anzueto, A., Adams, S., Orozco, C. & Ruiz, M., Oct 2011, In: Thorax. 66, 10, p. 894-902 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genome-Wide Association Study 100%
  • Chronic Obstructive Pulmonary Disease 85%
  • Single Nucleotide Polymorphism 80%
  • Tobacco Products 70%
  • Smoking 69%
  87 Scopus citations

• Inhibition by cigarette smoke of nuclear factor-κB-dependent response to bacteria in the airway

  Manzel, L. J., Shi, L., O'Shaughnessy, P. T., Thorne, P. S. & Look, D. C., Feb 1 2011, In: American Journal of Respiratory Cell and Molecular Biology. 44, 2, p. 155-165 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Smoke 100%
  • Tobacco Products 82%
  • Bacteria 59%
  • Haemophilus influenzae 27%
  • Epithelial Cells 17%
  31 Scopus citations

• The clinical features of the overlap between COPD and asthma

  COPDGene Investigators, Sep 27 2011, In: Respiratory Research. 12, 1, 127.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chronic Obstructive Pulmonary Disease 100%
  • Asthma 87%
  • Spirometry 27%
  • Smoking 27%
  • Thorax 17%
  364 Scopus citations
• 2010

  Inhibition of IFN-γ-dependent antiviral airway epithelial defense by cigarette smoke

  Modestou, M. A., Manzel, L. J., El-Mahdy, S. & Look, D. C., May 26 2010, In: Respiratory Research. 11, 64.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Smoke 100%
  • Tobacco Products 98%
  • Interferons 96%
  • Antiviral Agents 89%
  • Epithelial Cells 30%
  46 Scopus citations
• 2009

  Cigarette smoke alters respiratory syncytial virus-induced apoptosis and replication

  Groskreutz, D. J., Monick, M. M., Babor, E. C., Nyunoya, T., Varga, S. M., Look, D. C. & Hunninghake, G. W., Aug 1 2009, In: American Journal of Respiratory Cell and Molecular Biology. 41, 2, p. 189-198 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Respiratory Syncytial Viruses 100%
  • Smoke 96%
  • Tobacco Products 80%
  • Apoptosis 51%
  • Virus Diseases 35%
  42 Scopus citations

• Differential effects of cytokines and corticosteroids on Toll-like receptor 2 expression and activity in human airway epithelia

  Winder, A. A., Wohlford-Lenane, C., Scheetz, T. E., Nardy, B. N., Manzel, L. J., Look, D. C. & McCray, P. B., Oct 16 2009, In: Respiratory Research. 10, 96.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Toll-Like Receptor 2 100%
  • Human Activities 79%
  • Adrenal Cortex Hormones 63%
  • Epithelium 60%
  • Cytokines 48%
  30 Scopus citations

• Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia

  Hong, P. J., Look, D. C., Tan, P., Shi, L., Hickey, M., Gakhar, L., Chappell, M. C., Wohlford-Lenane, C. & McCray, P. B., Jul 2009, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 297, 1, p. L84-L96

  Research output: Contribution to journal › Article › peer-review

  • angiotensin converting enzyme 2 100%
  • Epithelium 51%
  • Severe Acute Respiratory Syndrome 19%
  • Disintegrins 9%
  • Coronavirus 9%
  259 Scopus citations

• Recognizing the importance of respiratory syncytial virus in chronic obstructive pulmonary disease

  Ramaswamy, M., Groskreutz, D. J. & Look, D. C., Feb 28 2009, In: COPD: Journal of Chronic Obstructive Pulmonary Disease. 6, 1, p. 64-75 12 p.

  Research output: Contribution to journal › Review article › peer-review

  • Respiratory Syncytial Viruses 100%
  • Chronic Obstructive Pulmonary Disease 75%
  • Respiratory Syncytial Virus Infections 30%
  • Viruses 10%
  • Environmental Exposure 8%
  25 Scopus citations

• Regulation of bacteria-induced intercellular adhesion molecule-1 by CCAAT/enhancer binding proteins

  Manzel, L. J., Chin, C. L., Behlke, M. A. & Look, D. C., Feb 1 2009, In: American Journal of Respiratory Cell and Molecular Biology. 40, 2, p. 200-210 11 p.

  Research output: Contribution to journal › Article › peer-review

  • CCAAT-Enhancer-Binding Proteins 100%
  • Enhancer 84%
  • Intercellular Adhesion Molecule-1 75%
  • Haemophilus influenzae 67%
  • Bacteria 48%
  12 Scopus citations
• 2008

  Respiratory epithelial cells convert inactive vitamin D to its active form: Potential effects on host defense

  Hansdottir, S., Monick, M. M., Hinde, S. L., Lovan, N., Look, D. C. & Hunninghake, G. W., Nov 15 2008, In: Journal of Immunology. 181, 10, p. 7090-7099 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Vitamin D 100%
  • Epithelial Cells 76%
  • Mixed Function Oxygenases 40%
  • CAP18 lipopolysaccharide-binding protein 25%
  • Genes 14%
  474 Scopus citations

• Serial isolates of persistent Haemophilus influenzae in patients with chronic obstructive pulmonary disease express diminishing quantities of the HMW1 and HMW2 adhesins

  Cholon, D. M., Cutter, D., Richardson, S. K., Sethi, S., Murphy, T. F., Look, D. C. & St. Geme, J. W., Oct 2008, In: Infection and immunity. 76, 10, p. 4463-4468 6 p.

  Research output: Contribution to journal › Article › peer-review

  • bacteria HMW2 protein 100%
  • bacteria HMW1 protein 96%
  • adhesins 60%
  • Haemophilus influenzae 57%
  • respiratory tract diseases 49%
  22 Scopus citations
• 2007

  Corrigendum to "Respiratory syncytial virus nonstructural protein 2 specifically inhibits type I interferon signal transduction" [Virology 344 (2006) 328-339] (DOI:10.1016/j.virol.2005.09.009)

  Ramaswamy, M., Shi, L., Varga, S. M., Barik, S., Behlke, M. A. & Look, D. C., Sep 30 2007, In: Virology. 366, 2, p. 453 1 p.

  Research output: Contribution to journal › Comment/debate

  Open Access

• Human adenovirus modulates surfactant phospholipid trafficking

  Miakotina, O. L., McCoy, D. M., Shi, L., Look, D. C. & Mallampalli, R. K., Dec 2007, In: Traffic. 8, 12, p. 1765-1777 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Human Adenoviruses 100%
  • ATP-Binding Cassette Transporters 89%
  • Phosphatidylcholines 82%
  • Surface-Active Agents 78%
  • Phosphatidylcholine 74%
  11 Scopus citations

• Increased arylsulfatase B activity in cystic fibrosis cells following correction of CFTR

  Bhattacharyya, S., Look, D. & Tobacman, J. K., May 1 2007, In: Clinica Chimica Acta. 380, 1-2, p. 122-127 6 p.

  Research output: Contribution to journal › Article › peer-review

  • N-Acetylgalactosamine-4-Sulfatase 100%
  • Cystic Fibrosis Transmembrane Conductance Regulator 76%
  • Cystic Fibrosis 59%
  • N-Acetylgalactosamine 4-Sulfate 48%
  • N-acetylgalactosamine 4-sulfate 36%
  23 Scopus citations

• Inhibition of Jak1-dependent signal transduction in airway epithelial cells infected with adenovirus

  Shi, L., Ramaswamy, M., Manzel, L. J. & Look, D. C., Dec 2007, In: American Journal of Respiratory Cell and Molecular Biology. 37, 6, p. 720-728 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Signal Transduction 100%
  • Adenoviridae 90%
  • Interferon Type I 82%
  • Epithelial Cells 66%
  • Janus Kinases 60%
  18 Scopus citations

• Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus

  McCray, P. B., Pewe, L., Wohlford-Lenane, C., Hickey, M., Manzel, L., Shi, L., Netland, J., Jia, H. P., Halabi, C., Sigmund, C. D., Meyerholz, D. K., Kirby, P., Look, D. C. & Perlman, S., Jan 2007, In: Journal of virology. 81, 2, p. 813-821 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Severe acute respiratory syndrome coronavirus 100%
  • K-18 conjugate 94%
  • angiotensin converting enzyme 2 86%
  • Severe Acute Respiratory Syndrome 74%
  • Coronavirus 72%
  645 Scopus citations

• Nonstructural proteins of respiratory syncytial virus suppress premature apoptosis by an NF-κB-dependent, interferon-independent mechanism and facilitate virus growth

  Bitko, V., Shulyayeva, O., Mazumder, B., Musiyenko, A., Ramaswamy, M., Look, D. C. & Barik, S., Feb 2007, In: Journal of virology. 81, 4, p. 1786-1795 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Respiratory syncytial virus 100%
  • Respiratory Syncytial Viruses 78%
  • interferons 75%
  • apoptosis 61%
  • Interferons 61%
  130 Scopus citations

• Paracellular permeability restricts airway epithelial responses to selectively allow activation by mediators at the basolateral surface

  Humlicek, A. L., Manzel, L. J., Chin, C. L., Shi, L., Excoffon, K. J. D. A., Winter, M. C., Shasby, D. M. & Look, D. C., May 15 2007, In: Journal of Immunology. 178, 10, p. 6395-6403 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Permeability 100%
  • Epithelium 88%
  • Inflammation 41%
  • Cytokines 28%
  • Haemophilus influenzae 26%
  39 Scopus citations

• Respiratory syncytial virus decreases p53 protein to prolong survival of airway epithelial cells

  Groskreutz, D. J., Monick, M. M., Yarovinsky, T. O., Powers, L. S., Quelle, D. E., Varga, S. M., Look, D. C. & Hunninghake, G. W., Sep 1 2007, In: Journal of Immunology. 179, 5, p. 2741-2747 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Respiratory Syncytial Viruses 100%
  • Epithelial Cells 60%
  • Survival 47%
  • nutlin 3 39%
  • Proteins 31%
  57 Scopus citations
• 2006

  A SARS-CoV-specific protein enhances virulence of an attenuated strain of mouse hepatitis virus

  Pewe, L., Zhou, H., Netland, J., Tangadu, C., Olivares, H., Shi, L., Look, D., Gallagher, T. & Perlman, S., 2006, The Nidoviruses: Toward Control of SARS and other Nidovirus Diseases. Springer New York, p. 493-498 6 p. (Advances in Experimental Medicine and Biology; vol. 581).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  Open Access
  4 Scopus citations

• Infection of human airway epithelia by sars coronavirus is associated with ACE2 expression and localization

  Jia, H. P., Look, D. C., Hickey, M., Shi, L., Pewe, L., Netland, J., Farzan, M., Wohlford-Lenane, C., Perlman, S. & McCray, P. B., 2006, The Nidoviruses: Toward Control of SARS and other Nidovirus Diseases. Springer New York, p. 479-484 6 p. (Advances in Experimental Medicine and Biology; vol. 581).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  Open Access
  19 Scopus citations

• Modulation of airway inflammation by Haemophilus influenzae isolates associated with chronic obstructive pulmonary disease exacerbation

  Look, D. C., Chin, C. L., Manzel, L. J., Lehman, E. E., Humlicek, A. L., Shi, L., Starner, T. D., Denning, G. M., Murphy, T. F. & Sethi, S., 2006, In: Proceedings of the American Thoracic Society. 3, 6, p. 482-483 2 p.

  Research output: Contribution to journal › Article › peer-review
  9 Scopus citations

• Respiratory syncytial virus induces TLR3 protein and protein kinase R, leading to increased double-stranded RNA responsiveness in airway epithelial cells

  Groskreutz, D. J., Monick, M. M., Powers, L. S., Yarovinsky, T. O., Look, D. C. & Hunninghake, G. W., Feb 1 2006, In: Journal of Immunology. 176, 3, p. 1733-1740 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Respiratory Syncytial Virus Infections 100%
  • Double-Stranded RNA 93%
  • Respiratory Syncytial Viruses 90%
  • Protein Kinases 71%
  • Epithelial Cells 55%
  217 Scopus citations

• Respiratory syncytial virus nonstructural protein 2 specifically inhibits type I interferon signal transduction

  Ramaswamy, M., Shi, L., Varga, S. M., Barik, S., Behlke, M. A. & Look, D. C., Jan 20 2006, In: Virology. 344, 2, p. 328-339 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interferon Type I 100%
  • Respiratory Syncytial Viruses 98%
  • Signal Transduction 65%
  • Respiratory Syncytial Virus Infections 31%
  • Proteins 30%
  135 Scopus citations
• 2005

  ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia

  Jia, H. P., Look, D. C., Shi, L., Hickey, M., Pewe, L., Netland, J., Farzan, M., Wohlford-Lenane, C., Perlman, S. & McCray, P. B., Dec 2005, In: Journal of virology. 79, 23, p. 14614-14621 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Severe acute respiratory syndrome coronavirus 100%
  • angiotensin converting enzyme 2 86%
  • Coronavirus Infections 83%
  • Severe Acute Respiratory Syndrome 74%
  • peptidyl-dipeptidase A 69%
  634 Scopus citations

• Adenovirus stimulates choline efflux by increasing expression of organic cation transporter-2

  Miakotina, O. L., Agassandian, M., Shi, L., Look, D. C. & Mallampalli, R. K., Jan 2005, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 288, 1 32-1, p. L93-L102

  Research output: Contribution to journal › Article › peer-review

  • Organic Cation Transporter 2 100%
  • Choline 62%
  • Adenoviridae 57%
  • Phenoxybenzamine 22%
  • Epithelium 19%
  13 Scopus citations

• A severe acute respiratory syndrome-associated coronavirus-specific protein enhances virulence of an attenuated murine coronavirus

  Pewe, L., Zhou, H., Netland, J., Tangudu, C., Olivares, H., Shi, L., Look, D., Gallagher, T. & Perlman, S., Sep 2005, In: Journal of virology. 79, 17, p. 11335-11342 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Murine coronavirus 100%
  • Murine hepatitis virus 77%
  • Coronavirinae 70%
  • Severe Acute Respiratory Syndrome 69%
  • Coronavirus 67%
  83 Scopus citations

• Haemophilus influenzae from patients with chronic obstructive pulmonary disease exacerbation induce more inflammation than colonizers

  Chin, C. L., Manzel, L. J., Lehman, E. E., Humlicek, A. L., Shi, L., Starner, T. D., Denning, G. M., Murphy, T. F., Sethi, S. & Look, D. C., Jul 1 2005, In: American journal of respiratory and critical care medicine. 172, 1, p. 85-91 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Haemophilus influenzae 100%
  • Chronic Obstructive Pulmonary Disease 78%
  • Disease Progression 70%
  • Inflammation 51%
  • Symptom Flare Up 50%
  134 Scopus citations

• NF-κB activation and sustained IL-8 gene expression in primary cultures of cystic fibrosis airway epithelial cells stimulated with Pseudomonas aeruginosa

  Joseph, T., Look, D. & Ferkol, T., Mar 2005, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 288, 3 32-3, p. L471-L479

  Research output: Contribution to journal › Article › peer-review

  • Cystic Fibrosis 100%
  • Interleukin-8 97%
  • Pseudomonas aeruginosa 95%
  • Epithelial Cells 73%
  • Gene Expression 61%
  88 Scopus citations

• Pyocyanin and its precursor phenazine-1-carboxylic acid increase IL-8 and intercellular adhesion molecule-1 expression in human airway epithelial cells by oxidant-dependent mechanisms

  Look, D. C., Stoll, L. L., Romig, S. A., Humlicek, A., Britigan, B. E. & Denning, G. M., Sep 15 2005, In: Journal of Immunology. 175, 6, p. 4017-4023 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 1-phenazinecarboxylic acid 100%
  • Pyocyanine 80%
  • Intercellular Adhesion Molecule-1 53%
  • Oxidants 53%
  • Interleukin-8 49%
  61 Scopus citations
• 2004

  Modulation of airway inflammation and bacterial clearance by epithelial cell ICAM-1

  Humlicek, A. L., Pang, L. & Look, D. C., Sep 2004, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 287, 3 31-3, p. L598-L607

  Research output: Contribution to journal › Article › peer-review

  • Cell Adhesion Molecule-1 100%
  • Epithelial Cell Adhesion Molecule 98%
  • Intercellular Adhesion Molecule-1 74%
  • Inflammation 41%
  • Neutrophils 27%
  37 Scopus citations

• Specific inhibition of type I interferon signal transduction by respiratory syncytial virus

  Ramaswamy, M., Shi, L., Monick, M. M., Hunninghake, G. W. & Look, D. C., Jun 1 2004, In: American Journal of Respiratory Cell and Molecular Biology. 30, 6, p. 893-900 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Interferon Type I 100%
  • Respiratory Syncytial Viruses 98%
  • Signal Transduction 90%
  • Interferons 67%
  • Epithelial Cells 37%
  111 Scopus citations
• 2002

  Inflammatory response in airway epithelial cells isolated from patients with cystic fibrosis

  Aldallal, N., McNaughton, E. E., Manzel, L. J., Richards, A. M., Zabner, J., Ferkol, T. W. & Look, D. C., Nov 1 2002, In: American journal of respiratory and critical care medicine. 166, 9, p. 1248-1256 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Cystic Fibrosis 100%
  • Epithelial Cells 73%
  • Interleukin-8 54%
  • Intercellular Adhesion Molecule-1 35%
  • Cystic Fibrosis Transmembrane Conductance Regulator 14%
  104 Scopus citations
• 2001

  Chinks in the armor of the airway: Pseudomonas infection in the cystic fibrosis lung

  Ferkol, T. W. & Look, D. C., Jan 1 2001, In: American Journal of Respiratory Cell and Molecular Biology. 25, 1, p. 11-13 3 p.

  Research output: Contribution to journal › Short survey › peer-review
  11 Scopus citations

• Effects of paramyxoviral infection on airway epithelial cell foxj1 expression, ciliogenesis, and mucociliary function

  Look, D. C., Walter, M. J., Williamson, M. R., Pang, L., You, Y., Sreshta, J. N., Johnson, J. E., Zander, D. S. & Brody, S. L., Dec 2001, In: American Journal of Pathology. 159, 6, p. 2055-2069 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Epithelial Cells 100%
  • Infections 66%
  • Respiratory Tract Infections 43%
  • Tubulin 33%
  • Gene Expression 27%
  72 Scopus citations

• Specific Inhibition of Interferon Signal Transduction Pathways by Adenoviral Infection

  Joseph, T. D. & Look, D. C., Dec 14 2001, In: Journal of Biological Chemistry. 276, 50, p. 47136-47142 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Signal Transduction 100%
  • Interferons 84%
  • Infections 44%
  • Interferon Receptors 32%
  • Epithelial Cells 29%
  35 Scopus citations
• 2000

  Haemophilus influenzae stimulates ICAM-1 expression on respiratory epithelial cells

  Frick, A. G., Joseph, T. D., Pang, L., Rabe, A. M., St. Geme, J. W. & Look, D. C., Apr 15 2000, In: Journal of Immunology. 164, 8, p. 4185-4196 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Haemophilus influenzae 100%
  • Intercellular Adhesion Molecule-1 91%
  • Epithelial Cells 62%
  • Interleukin-8 18%
  • Neutrophils 15%
  90 Scopus citations

• The osmolyte xylitol reduces the salt concentration of airway surface liquid and may enhance bacterial killing

  Zabner, J., Seiler, M. P., Launspach, J. L., Karp, P. H., Kearney, W. R., Look, D. C., Smith, J. J. & Welsh, M. J., Oct 10 2000, In: Proceedings of the National Academy of Sciences of the United States of America. 97, 21, p. 11614-11619 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Xylitol 100%
  • Salts 60%
  • Cystic Fibrosis 33%
  • Permeability 29%
  • Bacteria 23%
  105 Scopus citations
• 1999

  Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma

  Sampath, D., Castro, M., Look, D. C. & Holtzman, M. J., May 1999, In: Journal of Clinical Investigation. 103, 9, p. 1353-1361 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Transducers 100%
  • Asthma 76%
  • Intercellular Adhesion Molecule-1 61%
  • Cytokines 60%
  • Transcription Factors 29%
  201 Scopus citations

• Engineering viral vectors to subvert the airway defense response

  Look, D. C. & Brody, S. L., 1999, In: American Journal of Respiratory Cell and Molecular Biology. 20, 6, p. 1103-1106 4 p.

  Research output: Contribution to journal › Review article › peer-review
  30 Scopus citations

• Virus-inducible expression of a host chemokine gene relies on replication-linked mRNA stabilization

  Koga, T., Sardiña, E., Tidwell, R. M., Pelletier, M., Look, D. C. & Holtzman, M. J., May 11 1999, In: Proceedings of the National Academy of Sciences of the United States of America. 96, 10, p. 5680-5685 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Chemokines 100%
  • Viruses 71%
  • T-Lymphocytes 65%
  • Messenger RNA 60%
  • Respiratory Syncytial Viruses 56%
  59 Scopus citations
• 1998

  Control of epithelial immune-response genes and implications for airway immunity and inflammation

  Holtzman, M. J., Look, D. C., Sampath, D., Castro, M., Koga, T. & Walter, M. J., Feb 6 1998, In: Proceedings of the Association of American Physicians. 110, 1, p. 1-11 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Immunity 100%
  • Interferon-gamma 73%
  • Inflammation 72%
  • Asthma 63%
  • Viruses 54%
  28 Scopus citations

• Direct suppression of Stat1 function during adenoviral infection

  Look, D. C., Roswit, W. T., Frick, A. G., Gris-Alevy, Y., Dickhaus, D. M., Walter, M. J. & Holtzman, M. J., Dec 1998, In: Immunity. 9, 6, p. 871-880 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • p300-CBP Transcription Factors 100%
  • STAT Transcription Factors 86%
  • Oncogene Proteins 66%
  • Transcriptional Activation 53%
  • Transcription Factors 44%
  142 Scopus citations

• Patterns for RANTES secretion and intercellular adhesion molecule 1 expression mediate transepithelial T cell traffic based on analyses in vitro and in vivo

  Taguchi, M., Sampath, D., Koga, T., Castro, M., Look, D. C., Nakajima, S. & Holtzman, M. J., Jun 15 1998, In: Journal of Experimental Medicine. 187, 12, p. 1927-1940 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Intercellular Adhesion Molecule-1 100%
  • T-Lymphocytes 59%
  • In Vitro Techniques 41%
  • Epithelium 19%
  • Direction compound 18%
  81 Scopus citations
• 1997

  Targeted inhibition of interferon-γ-dependent intercellular adhesion molecule-1 (ICAM-1) expression using dominant-negative Stat1

  Walter, M. J., Look, D. C., Tidwell, R. M., Roswit, W. T. & Holtzman, M. J., Nov 7 1997, In: Journal of Biological Chemistry. 272, 45, p. 28582-28589 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Intercellular Adhesion Molecule-1 100%
  • Interferons 87%
  • Signal Transduction 68%
  • Mutation 53%
  • Heterodimerization 47%
  85 Scopus citations
• 1996

  STAT-1 and SP1 interact to synergistically activate ICAM-1 gene transcription

  Look, D., Pelletier, M., Tidwell, R., Roswit, W. & Hfiltzmm, M., Dec 1 1996, In: FASEB Journal. 10, 6, p. A1516

  Research output: Contribution to journal › Article › peer-review

  • Intercellular Adhesion Molecule-1 100%
  • Transducers 97%
  • Protein 39%
  • Genes 38%
  • Transfection 32%

• The One-two of T Helper Cells: Does Interferon-γ Knock Out the Th2 Hypothesis for Asthma?

  Holtzman, M. J., Sampath, D., Castro, M., Look, D. C. & Jayaraman, S., 1996, In: American Journal of Respiratory Cell and Molecular Biology. 14, 4, p. 316-318 3 p.

  Research output: Contribution to journal › Review article › peer-review
  79 Scopus citations