Douglas Mann

Tobias and Hortense Lewin Professor of Medicine, Professor of Cell Biology and Physiology

  • 32570 Citations
1965 …2019
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Personal profile

Research interests

The major focus of Dr. Mann's laboratory research has been to define the basic cellular and molecular mechanism(s) that are responsible for disease progression in the failing heart. His research efforts have focused on translating novel findings obtained in the basic research laboratory into multicenter clinical trials. Dr. Mann's current basic research efforts have centered on the role of innate immunity in the heart with respect to regulating cardiac structure and function.

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  • 7 Similar Profiles
Heart Failure Medicine & Life Sciences
Tumor Necrosis Factor-alpha Medicine & Life Sciences
Ventricular Remodeling Medicine & Life Sciences
Cytokines Medicine & Life Sciences
Heart-Assist Devices Medicine & Life Sciences
Cardiac Myocytes Medicine & Life Sciences
Stroke Volume Medicine & Life Sciences
Myocardium Medicine & Life Sciences

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Research Output 1965 2019

1 Citation (Scopus)

Ambulatory Advanced Heart Failure in Women: A Report From the REVIVAL Registry

REVIVAL Investigators, Jul 1 2019, In : JACC: Heart Failure. 7, 7, p. 602-611 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Heart Failure
Quality of Life
Systolic Heart Failure
Heart-Assist Devices

Association between mortality and implantable cardioverter-defibrillators by aetiology of heart failure: a propensity-matched analysis of the WARCEF trial

for the WARCEF Investigators, Apr 1 2019, In : ESC Heart Failure. 6, 2, p. 297-307 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Implantable Defibrillators
Heart Failure
1 Citation (Scopus)

Characterization of the Obese Phenotype of Heart Failure With Preserved Ejection Fraction: A RELAX Trial Ancillary Study

Reddy, Y. N. V., Lewis, G. D., Shah, S. J., Obokata, M., Abou-Ezzedine, O. F., Fudim, M., Sun, J. L., Chakraborty, H., McNulty, S., LeWinter, M. M., Mann, D., Stevenson, L. W., Redfield, M. M. & Borlaug, B. A., Jul 1 2019, In : Mayo Clinic Proceedings. 94, 7, p. 1199-1209 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Heart Failure
Body Mass Index
Quality of Life

Current Education of Physicians: Lost in Translation?

Schafer, A. I. & Mann, D., Sep 1 2019, In : JACC: Basic to Translational Science. 4, 5, p. 655-657 3 p.

Research output: Contribution to journalEditorialResearch

Open Access
6 Citations (Scopus)

Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation

Li, W., Feng, G., Gauthier, J. M., Lokshina, I., Higashikubo, R., Evans, S., Liu, X., Hassan, A., Tanaka, S., Cicka, M., Hsiao, H. M., Ruiz-Perez, D., Bredemeyer, A., Gross, R., Mann, D., Tyurina, Y. Y., Gelman, A., Kagan, V. E., Linkermann, A., Lavine, K. & 1 others, Kreisel, D., Jun 3 2019, In : Journal of Clinical Investigation. 129, 6, p. 2293-2304 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Neutrophil Infiltration
Heart Transplantation
Cell Death
Reperfusion Injury