Research output per year
Research output per year
- 200 - 250 out of 361 results
Search results
-
Article
Neurosteroid analogues. 6. The synthesis and GABA(A) receptor pharmacology of enantiomers of dehydroepiandrosterone sulfate, pregnenolone sulfate, and (3α,5β)-3-hydroxypregnan-20-one sulfate
Nilsson, K. R., Zorumski, C. F. & Covey, D. F., Jul 2 1998, In: Journal of Medicinal Chemistry. 41, 14, p. 2604-2613 10 p.Research output: Contribution to journal › Article › peer-review
67 Scopus citations -
Neurosteroid Analogues. 9. Conformationally Constrained Pregnanes: Structure-Activity Studies of 13,24-Cyclo-18,21-dinorcholane Analogues of the GABA Modulatory and Anesthetic Steroids (3α,5α)- and (3α,5β)-3-Hydroxypregnan-20-one
Jiang, X., Manion, B. D., Benz, A., Rath, N. P., Evers, A. S., Zorumski, C. F., Mennerick, S. & Covey, D. F., Dec 4 2003, In: Journal of Medicinal Chemistry. 46, 25, p. 5334-5348 15 p.Research output: Contribution to journal › Article › peer-review
31 Scopus citations -
Neurosteroid analogues. Part 13: Synthetic methods for the preparation of 2β-hydroxygonane derivatives as structural mimics of ent-3α-hydroxysteroid modulators of GABAA receptors
Wang, C., Rath, N. P. & Covey, D. F., Aug 13 2007, In: Tetrahedron. 63, 33, p. 7977-7984 8 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Neurosteroid analogues. Part 5. Enantiomers of neuroactive steroids and benz[e]indenes: Total synthesis, electrophysiological effects on GABAA receptor function and anesthetic actions in tadpoles
Hu, Y., Wittmer, L. L., Kalkbrenner, M., Evers, A. S., Zorumski, C. F. & Covey, D. F., Dec 21 1997, In: Journal of the Chemical Society - Perkin Transactions 1. 24, p. 3665-3671 7 p.Research output: Contribution to journal › Article › peer-review
37 Scopus citations -
Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABA-A receptor potentiation
Li, P., Shu, H. J., Wang, C., Mennerick, S., Zorumski, C. F., Covey, D. F., Steinbach, J. H. & Akk, G., Nov 1 2007, In: Journal of Physiology. 584, 3, p. 789-800 12 p.Research output: Contribution to journal › Article › peer-review
27 Scopus citations -
Neurosteroid Modulation of GABAA Receptor Function by Independent Action at Multiple Specific Binding Sites
Wang, L., Covey, D. F., Akk, G. & Evers, A., May 2022, In: Current Neuropharmacology. 20, 5, p. 886-890 5 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond
Zorumski, C. F., Paul, S. M., Covey, D. F. & Mennerick, S., Nov 2019, In: Neurobiology of Stress. 11, 100196.Research output: Contribution to journal › Article › peer-review
Open Access71 Scopus citations -
Neurosteroids enhance spontaneous glutamate release in hippocampal neurons. Possible role of metabotropic sigma1-like receptors.
Meyer, D. A., Carta, M., Partridge, L. D., Covey, D. F. & Valenzuela, C. F., Aug 9 2002, In: The Journal of biological chemistry. 277, 32, p. 28725-28732 8 p.Research output: Contribution to journal › Article › peer-review
Open Access121 Scopus citations -
New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5α-reduced neuroactive steroids
Pathirathna, S., Brimelow, B. C., Jagodic, M. M., Krishnan, K., Jiang, X., Zorumski, C. F., Mennerick, S., Covey, D. F., Todorovic, S. M. & Jevtovic-Todorovic, V., Apr 2005, In: Pain. 114, 3, p. 429-443 15 p.Research output: Contribution to journal › Article › peer-review
117 Scopus citations -
NMDA potentiation by visible light in the presence of a fluorescent neurosteroid analogue
Eisenman, L. N., Shu, H. J., Wang, C., Aizenman, E., Covey, D. F., Zorumski, C. F. & Mennerick, S., Jun 15 2009, In: Journal of Physiology. 587, 12, p. 2937-2947 11 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Novel neuroactive steroid with hypnotic and T-type calcium channel blocking properties exerts effective analgesia in a rodent model of post-surgical pain
Joksimovic, S. L., Joksimovic, S. M., Manzella, F. M., Asnake, B., Orestes, P., Raol, Y. H., Krishnan, K., Covey, D. F., Jevtovic-Todorovic, V. & Todorovic, S. M., Apr 1 2020, In: British Journal of Pharmacology. 177, 8, p. 1735-1753 19 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Novel neurosteroid hypnotic blocks T-type calcium channel-dependent rebound burst firing and suppresses long-term potentiation in the rat subiculum
Joksimovic, S. M., Izumi, Y., Joksimovic, S. L., Tesic, V., Krishnan, K., Asnake, B., Jevtovic-Todorovic, V., Covey, D. F., Zorumski, C. F. & Todorovic, S. M., May 2019, In: British journal of anaesthesia. 122, 5, p. 643-651 9 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Oxidative stress in NPC1 deficient cells: Protective effect of allopregnanolone
Zampieri, S., Mellon, S. H., Butters, T. D., Nevyjel, M., Covey, D. F., Bembi, B. & Dardis, A., Sep 2009, In: Journal of Cellular and Molecular Medicine. 13, 9 B, p. 3786-3796 11 p.Research output: Contribution to journal › Article › peer-review
92 Scopus citations -
Oxysterols are allosteric activators of the oncoprotein Smoothened
Nachtergaele, S., Mydock, L. K., Krishnan, K., Rammohan, J., Schlesinger, P. H., Covey, D. F. & Rohatgi, R., Feb 2012, In: Nature Chemical Biology. 8, 2, p. 211-220 10 p.Research output: Contribution to journal › Article › peer-review
221 Scopus citations -
Oxysterols as non-genomic regulators of cholesterol homeostasis
Bielska, A. A., Schlesinger, P., Covey, D. F. & Ory, D. S., Mar 2012, In: Trends in Endocrinology and Metabolism. 23, 3, p. 99-106 8 p.Research output: Contribution to journal › Article › peer-review
38 Scopus citations -
Palladium-catalyzed potassium enoxyborate alkylation of enantiopure Hajos-Parrish indenone to construct rearranged steroid ring systems
Jastrzebska, I., Scaglione, J. B., DeKoster, G. T., Rath, N. P. & Covey, D. F., Jun 22 2007, In: Journal of Organic Chemistry. 72, 13, p. 4837-4843 7 p.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
Partial structures of the fungal toxin aflatrem, methyl-substituted 6,8-dioxabicyclo[3.2.1]octan-2-ones have anticonvulsant activity
Tinao-Wooldridge, L. V., Hsiang, B. C. H., Latifi, T. N., Ferrendelli, J. A. & Covey, D. F., Feb 2 1995, In: Bioorganic and Medicinal Chemistry Letters. 5, 3, p. 265-270 6 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain
Kinnebrew, M., Woolley, R. E., Ansell, T. B., Byrne, E. F. X., Frigui, S., Luchetti, G., Sircar, R., Nachtergaele, S., Mydock-McGrane, L., Krishnan, K., Newstead, S., Sansom, M. S. P., Covey, D. F., Siebold, C. & Rohatgi, R., Jun 2022, In: Science Advances. 8, 22, eabm5563.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Pentylenetetrazole-induced inhibition of recombinant γ-aminobutyric acid type A (GABAA) receptors: Mechanism and site of action
Huang, R. Q., Bell-Horner, C. L., Dibas, M. I., Covey, D. F., Drewe, J. A. & Dillon, G. H., Aug 29 2001, In: Journal of Pharmacology and Experimental Therapeutics. 298, 3, p. 986-995 10 p.Research output: Contribution to journal › Article › peer-review
301 Scopus citations -
Photoaffinity labeling with a neuroactive steroid analogue: 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain
Darbandi-Tonkabon, R., Hastings, W. R., Zeng, C. M., Akk, G., Manion, B. D., Bracamontes, J. R., Steinbach, J. H., Mennerick, S. J., Covey, D. F. & Evers, A. S., Apr 11 2003, In: Journal of Biological Chemistry. 278, 15, p. 13196-13206 11 p.Research output: Contribution to journal › Article › peer-review
Open Access65 Scopus citations -
Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1
Budelier, M. M., Cheng, W. W. L., Bergdoll, L., Chen, Z. W., Janetka, J. W., Abramson, J., Krishnan, K., Mydock-McGrane, L., Covey, D. F., Whitelegge, J. P. & Evers, A. S., Jun 2 2017, In: Journal of Biological Chemistry. 292, 22, p. 9294-9304 11 p.Research output: Contribution to journal › Article › peer-review
Open Access43 Scopus citations -
Photodynamic effects of steroid-conjugated fluorophores on GABAA receptors
Shu, H. J., Eisenman, L. N., Wang, C., Bandyopadhyaya, A. K., Krishnan, K., Taylor, A., Benz, A. M., Manion, B., Evers, A. S., Covey, D. F., Zorumski, C. F. & Mennerick, S., Oct 2009, In: Molecular pharmacology. 76, 4, p. 754-765 12 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Photoreceptor preservation in the S334ter model of retinitis pigmentosa by a novel estradiol analog
Dykens, J. A., Carroll, A. K., Wiley, S., Covey, D. F., Cai, Z. Y., Zhao, L. & Wen, R., Nov 15 2004, In: Biochemical Pharmacology. 68, 10, p. 1971-1984 14 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
Physiological comparison of α-ethyl-α-methyl-γ-thiobutyrolactone with benzodiazepine and barbiturate modulators of GABAA receptors
Mathews, G. C., Bolos-Sy, A. M., Covey, D. F., Rothman, S. M. & Ferrendelli, J. A., Feb 1996, In: Neuropharmacology. 35, 2, p. 123-136 14 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
Physiological modulation of the GABA receptor by convulsant and anticonvulsant barbiturates in cultured rat hippocampal neurons
Holland, K. D., Canney, D. J., Rothman, S. M., Ferrendelli, J. A. & Covey, D. F., May 14 1990, In: Brain Research. 516, 1, p. 147-150 4 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Physiological regulation of the picrotoxin receptor by γ-butyrolactones and γ-thiobutyrolactones in cultured hippocampal neurons
Holland, K. D., Ferrendelli, J. A., Covey, D. F. & Rothman, S. M., 1990, In: Journal of Neuroscience. 10, 6, p. 1719-1727 9 p.Research output: Contribution to journal › Article › peer-review
Open Access31 Scopus citations -
Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion channel through one of two binding sites
Dietzen, N. M., Arcario, M. J., Chen, L. J., Petroff, J. T., Moreland, K. T., Krishnan, K., Brannigan, G., Covey, D. F. & Cheng, W. W. L., Jan 2022, In: eLife. 11, e74306.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Potential clinical uses of neuroactive steroids
Zorumski, C. F., Mennerick, S., Isenberg, K. E. & Covey, D. F., Sep 1 2000, In: IDrugs. 3, 9, p. 1053-1063 11 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Preemptive Analgesic Effect of Intrathecal Applications of Neuroactive Steroids in a Rodent Model of Post-Surgical Pain: Evidence for the Role of T-Type Calcium Channels
Tat, Q. L., Joksimovic, S. M., Krishnan, K., Covey, D. F., Todorovic, S. M. & Jevtovic-Todorovic, V., Dec 12 2020, In: Cells. 9, 12, 2662.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Pregnane X receptor (PXR) activation: A mechanism for neuroprotection in a mouse model of Niemann-Pick C disease
Langmade, S. J., Gale, S. E., Frolov, A., Mohri, I., Suzuki, K., Mellon, S. H., Walkley, S. U., Covey, D. F., Schaffer, J. E. & Ory, D. S., Sep 12 2006, In: Proceedings of the National Academy of Sciences of the United States of America. 103, 37, p. 13807-13812 6 p.Research output: Contribution to journal › Article › peer-review
138 Scopus citations -
Pregnenolone sulfate and dehydroepiandrosterone sulfate inhibit GABA-gated chloride currents in Xenopus oocytes expressing picrotoxin-insensitive GABA(A) receptors
Shen, W., Mennerick, S., Zorumski, E. C., Covey, D. F. & Zorumski, C. F., Feb 1999, In: Neuropharmacology. 38, 2, p. 267-271 5 p.Research output: Contribution to journal › Article › peer-review
54 Scopus citations -
Pregnenolone sulfate and its enantiomer: Differential modulation of memory in a spatial discrimination task using forebrain NMDA receptor deficient mice
Petit, G. H., Tobin, C., Krishnan, K., Moricard, Y., Covey, D. F., Rondi-Reig, L. & Akwa, Y., Feb 2011, In: European Neuropsychopharmacology. 21, 2, p. 211-215 5 p.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
Pregnenolone sulfate modulates inhibitory synaptic transmission by enhancing GABA(A) receptor desensitization
Shen, W., Mennerick, S., Covey, D. F. & Zorumski, C. F., May 15 2000, In: Journal of Neuroscience. 20, 10, p. 3571-3579 9 p.Research output: Contribution to journal › Article › peer-review
Open Access90 Scopus citations -
Preparation of 14,15-secoestra-1,3,5(10)-trien-15-ynes, inhibitors of estradiol dehydrogenase
Auchus, R. J., Palmer, J. O., Carrell, H. L. & Covey, D. F., 1989, In: Steroids. 53, 1-2, p. 77-96 20 p.Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
Quantitative imaging of membrane contact sites for sterol transfer between endo-lysosomes and mitochondria in living cells
Juhl, A. D., Heegaard, C. W., Werner, S., Schneider, G., Krishnan, K., Covey, D. F. & Wüstner, D., Apr 26 2021, In: Scientific reports. 11, 1, p. 8927 1 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Racemic progesterone: Predicted in silico and produced in the solid state
Lancaster, R. W., Karamertzanis, P. G., Hulme, A. T., Tocher, D. A., Covey, D. F. & Price, S. L., 2006, In: Chemical Communications. 47, p. 4921-4923 3 p.Research output: Contribution to journal › Article › peer-review
39 Scopus citations -
Rapid transient absorption and biliary secretion of enantiomeric cholesterol in hamsters
Westover, E. J., Lin, X., Riehl, T. E., Ma, L., Stenson, W. F., Covey, D. F. & Ostlund, R. E., Nov 2006, In: Journal of lipid research. 47, 11, p. 2374-2381 8 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Recent developments in structure-activity relationships for steroid modulators of GABAA receptors
Covey, D. F., Evers, A. S., Mennerick, S., Zorumski, C. F. & Purdy, R. H., 2001, In: Brain Research Reviews. 37, 1-3, p. 91-97 7 p.Research output: Contribution to journal › Article › peer-review
70 Scopus citations -
Regioselectivity and stereospecificity in homoketonizations. Control by thermodynamic and steric factors.
Nickon, A., Covey, D. F., Pandit, G. D. & Frank, J. J., 1975, In: Tetrahedron Letters. 16, 43, p. 3681-3684 4 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
Relationship between phosphatidylinositol 4-phosphate synthesis, membrane organization, and lateral diffusion of PI4KIIα at the trans-Golgi network
Minogue, S., Chu, K. M. E., Westover, E. J., Covey, D. F., Hsuan, J. J. & Waugh, M. G., Aug 2010, In: Journal of lipid research. 51, 8, p. 2314-2324 11 p.Research output: Contribution to journal › Article › peer-review
Open Access49 Scopus citations -
Relative Anticonvulsant Effects of GABAmimetic and GABA Modulatory Agents
Holland, K. D., McKeon, A. C., Canney, D. J., Covey, D. F. & Ferrendelli, J. A., Nov 1992, In: Epilepsia. 33, 6, p. 981-986 6 p.Research output: Contribution to journal › Article › peer-review
56 Scopus citations -
Reversal of neuropathic pain in diabetes by targeting glycosylation of Cav3.2 T-type calcium channels
Orestes, P., Osuru, H. P., McIntire, W. E., Jacus, M. O., Salajegheh, R., Jagodic, M. M., Choe, W. J., Lee, J. H., Lee, S. S., Rose, K. E., Poiro, N., DiGruccio, M. R., Krishnan, K., Covey, D. F., Lee, J. H., Barrett, P. Q., Jevtovic-Todorovic, V. & Todorovic, S. M., Nov 2013, In: Diabetes. 62, 11, p. 3828-3838 11 p.Research output: Contribution to journal › Article › peer-review
Open Access89 Scopus citations -
Role of nonfeminizing estrogen analogues in neuroprotection of rat retinal ganglion cells against glutamate-induced cytotoxicity
Kumar, D. M., Perez, E., Cai, Z. Y., Aoun, P., Brun-Zinkernagel, A. M., Covey, D. F., Simpkins, J. W. & Agarwal, N., May 1 2005, In: Free Radical Biology and Medicine. 38, 9, p. 1152-1163 12 p.Research output: Contribution to journal › Article › peer-review
48 Scopus citations -
Role of Substrate Conformational Features in the Stereospecificity of Aromatase
Beusen, D. D., Kalman, B. L. & Covey, D. F., Feb 1986, In: Biochemistry. 25, 3, p. 662-667 6 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Secosteroid Mechanism-Based Inactivators and Site-Directed Mutagenesis as Probes for Steroid Hormone Recognition by 3α-Hydroxysteroid Dehydrogenase
Schlegel, B. P., Pawlowski, J. E., Penning, T. M., Hu, Y., Scolnick, D. M. & Covey, D. F., Aug 1 1994, In: Biochemistry. 33, 34, p. 10367-10374 8 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Selective antagonism of 5α-reduced neurosteroid effects at GABA A receptors
Mennerick, S., He, Y., Jiang, X., Manion, B. D., Wang, M., Shute, A., Benz, A., Evers, A. S., Covey, D. F. & Zorumski, C. F., May 2004, In: Molecular pharmacology. 65, 5, p. 1191-1197 7 p.Research output: Contribution to journal › Article › peer-review
76 Scopus citations -
Selective inhibition of rat epididymal steroid Δ4-5α-reductase> by conjugated allenic 3-oxo-5,10-secosteroids
Robairf, B., Covey, D. F., Robinson, C. H. & Ewing, L. L., Apr 1977, In: Journal of Steroid Biochemistry. 8, 4, p. 307-310 4 p.Research output: Contribution to journal › Article › peer-review
38 Scopus citations -
Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice
Latham, J. R., Pathirathna, S., Jagodic, M. M., Won, J. C., Levin, M. E., Nelson, M. T., Woo, Y. L., Krishnan, K., Covey, D. F., Todorovic, S. M. & Jevtovic-Todorovic, V., Nov 2009, In: Diabetes. 58, 11, p. 2656-2665 10 p.Research output: Contribution to journal › Article › peer-review
Open Access105 Scopus citations -
Sex-specific hypnotic effects of the neuroactive steroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile are mediated by peripheral metabolism into an active hypnotic steroid
Manzella, F. M., Cabrera, O. H., Wilkey, D., Fine-Raquet, B., Klawitter, J., Krishnan, K., Covey, D. F., Jevtovic-Todorovic, V. & Todorovic, S. M., Feb 2023, In: British journal of anaesthesia. 130, 2, p. 154-164 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions
Gale, S. E., Westover, E. J., Dudley, N., Krishnan, K., Merlin, S., Scherrer, D. E., Han, X., Zhai, X., Brockman, H. L., Brown, R. E., Covey, D. F., Schaffer, J. E., Schlesinger, P. & Ory, D. S., Jan 16 2009, In: Journal of Biological Chemistry. 284, 3, p. 1755-1764 10 p.Research output: Contribution to journal › Article › peer-review
Open Access63 Scopus citations