Douglas Covey

Article

[19-¹⁴C]androstenedione: A new substrate for assaying aromatase and studying its reaction mechanism

Covey, D. F., McMullan, P. C., Wixler, L. L. & Cabell, M., Nov 30 1988, In: Biochemical and Biophysical Research Communications. 157, 1, p. 81-86 6 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

10β-Propynyl-substituted steroids. Mechanism-based enzyme-activated irreversible inhibitors to estrogen biosynthesis

Covey, D. F., Hood, W. F. & Parikh, V. D., 1981, In: Journal of Biological Chemistry. 256, 3, p. 1076-1079 4 p.

Research output: Contribution to journal › Article › peer-review

134 Scopus citations

11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: Potent general anesthetics and photolabeling reagents for GABA_A receptors

Chen, Z. W., Wang, C., Krishnan, K., Manion, B. D., Hastings, R., Bracamontes, J., Taylor, A., Eaton, M. M., Zorumski, C. F., Steinbach, J. H., Akk, G., Mennerick, S., Covey, D. F. & Evers, A. S., Sep 2014, In: Psychopharmacology. 231, 17, p. 3479-3491 13 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

¹³C Nuclear Magnetic Resonance as a Monitor for Anionic Exchange Processes.¹ Remote Epimerization via Homoenolate Ions and Aryl D Exchange

Hunter, D. H., Johnson, A. L., Stothers, J. B., Nickon, A., Lambert, J. L. & Covey, D. F., Nov 1 1972, In: Journal of the American Chemical Society. 94, 24, p. 8582-8584 3 p.

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner

Wong, M. Y., Lewis, M., Doherty, J. J., Shi, Y., Cashikar, A. G., Amelianchik, A., Tymchuk, S., Sullivan, P. M., Qian, M., Covey, D. F., Petsko, G. A., Holtzman, D. M., Paul, S. M., Paul, S. M. & Luo, W., Jun 17 2020, In: Journal of Neuroinflammation. 17, 1, 192.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

3,3-Dialkyl- and 3-alkyl-3-benzyl-substituted 2-pyrrolidinones: A new class of anticonvulsant agents

Reddy, P. A., Hsiang, B. C. H., Latifi, T. N., Hill, M. W., Woodward, K. E., Rothman, S. M., Ferrendelli, J. A. & Covey, D. F., Apr 26 1996, In: Journal of Medicinal Chemistry. 39, 9, p. 1898-1906 9 p.

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

3β-Hydroxypregnane Steroids Are Pregnenolone Sulfate-Like GABA _A Receptor Antagonists

Wang, M., He, Y., Eisenman, L. N., Fields, C., Zeng, C. M., Mathews, J., Benz, A., Fu, T., Zorumski, E., Steinbach, J. H., Covey, D. F., Zorumski, C. F. & Mennerick, S., May 1 2002, In: Journal of Neuroscience. 22, 9, p. 3366-3375 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

134 Scopus citations

4β-Hydroxycholesterol is a prolipogenic factor that promotes SREBP1c expression and activity through the liver X receptor

Moldavski, O., Zushin, P. J. H., Berdan, C. A., Van Eijkeren, R. J., Jiang, X., Qian, M., Ory, D. S., Covey, D. F., Nomura, D. K., Stahl, A., Weiss, E. J. & Zoncu, R., 2021, In: Journal of lipid research. 62, 100051.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

5α-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic pain

Pathirathna, S., Todorovic, S. M., Covey, D. F. & Jevtovic-Todorovic, V., Oct 2005, In: Pain. 117, 3, p. 326-339 14 p.

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

5β-Reduced neuroactive steroids are novel voltage-dependent blockers of T-type Ca²⁺ channels in rat sensory neurons in vitro and potent peripheral analgesics in vivo

Todorovic, S. M., Pathirathna, S., Brimelow, B. C., Jagodic, M. M., Ko, S. H., Jiang, X., Nilsson, K. R., Zorumski, C. F., Covey, D. F. & Jevtovic-Todorovic, V., Nov 2004, In: Molecular pharmacology. 66, 5, p. 1223-1235 13 p.

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abnormal Beckmann fragmentation/ring closing metathesis route for preparation of 18-nor-Δ¹³⁽¹⁷⁾-androgens and their 18-nor-13,17-epoxide derivatives

Wang, C., Rath, N. P. & Covey, D. F., Nov 6 2006, In: Tetrahedron Letters. 47, 45, p. 7837-7839 3 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Acid Homoketonization with Inversion of Configuration. Dramatic Effect of Water in Control of Stereochemistry

Nickon, A., Frank, J. J., Covey, D. F. & Lin, Y. I., Nov 1 1974, In: Journal of the American Chemical Society. 96, 24, p. 7574-7576 3 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

A clickable neurosteroid photolabel reveals selective Golgi compartmentalization with preferential impact on proximal inhibition

Jiang, X., Shu, H. J., Krishnan, K., Qian, M., Taylor, A. A., Covey, D. F., Zorumski, C. F. & Mennerick, S., Sep 1 2016, In: Neuropharmacology. 108, p. 193-206 14 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

A Clickable Oxysterol Photolabel Retains NMDA Receptor Activity and Accumulates in Neurons

Chen, D. M., Ziolkowski, L., Benz, A., Qian, M., Zorumski, C. F., Covey, D. F. & Mennerick, S., Dec 6 2018, In: Frontiers in Neuroscience. 12, 923.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Additive neuroprotective effects of 24(S)-hydroxycholesterol and allopregnanolone in an ex vivo rat glaucoma model

Ishikawa, M., Yoshitomi, T., Covey, D. F., Zorumski, C. F. & Izumi, Y., Dec 1 2018, In: Scientific reports. 8, 1, 12851.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

A facile total synthesis of ent-17β-estradiol and structurally related analogues

Cai, Z. Y. & Covey, D. F., Apr 2007, In: Steroids. 72, 4, p. 351-359 9 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Affinity Labeling of Human Placental 3β-Hydroxy-Δ⁵-steroid Dehydrogenase and Steroid-Isomerase: Evidence for Bifunctional Catalysis by a Different Conformation of the Same Protein for Each Enzyme Activity

Thomas, J. L., Strickler, R. C., Myers, R. P. & Covey, D. F., Feb 1 1992, In: Biochemistry. 31, 24, p. 5522-5527 6 p.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Aggregate formation from 3-alkylindoles: Amphiphilic models for interfacial helix anchoring groups

Abel, E., De Wall, S. L., Edwards, W. B., Lalitha, S., Covey, D. F. & Gokel, G. W., Mar 21 2000, In: Chemical Communications. 6, p. 433-434 2 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Alkyl-Substituted Thiolo-, Thiono-, and Dithio-γ-butyrolactones: New Classes of Convulsant and Anticonvulsant Agents

Levine, J. A., Ferrendelli, J. A. & Covey, D. F., 1986, In: Journal of Medicinal Chemistry. 29, 10, p. 1996-1999 4 p.

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Alkyl-substituted γ-butyrolactones act at a distinct site allosterically linked to the TBPS/picrotoxinin site on the GABA_A receptor complex

Holland, K. D., Bouley, M. G., Covey, D. F. & Ferrendelli, J. A., Jun 25 1993, In: Brain Research. 615, 1, p. 170-174 5 p.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Alkyl-substituted γ-butyrolactones as potential tools in the study and treatment of epilepsy

Klunk, W. E., Covey, D. F. & Ferrendelli, J. A., Oct 15 1983, In: Biochemical Pharmacology. 32, 20, p. 2999-3004 6 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Alpha-substituted γ-butyrolactones: New class of anticonvulsant drugs

Klunk, W. E., McKeon, A. C., Covey, D. F. & Ferrendelli, J. A., 1982, In: Science. 217, 4564, p. 1040-1042 3 p.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Analysis of GABA_A receptor activation by combinations of agonists acting at the same or distinct binding sites

Shin, D. J., Germann, A. L., Covey, D. F., Steinbach, J. H. & Akk, G., Jan 2019, In: Molecular pharmacology. 95, 1, p. 70-81 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

A neuroactive steroid with a therapeutically interesting constellation of actions at GABA_A and NMDA receptors

Ziolkowski, L., Mordukhovich, I., Chen, D. M., Chisari, M., Shu, H. J., Lambert, P. M., Qian, M., Zorumski, C. F., Covey, D. F. & Mennerick, S., Feb 1 2021, In: Neuropharmacology. 183, 108358.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

A neurosteroid analogue photolabeling reagent labels the colchicine-binding site on tubulin: A mass spectrometric analysis

Chen, Z. W., Chen, L. H., Akentieva, N., Lichti, C. F., Darbandi, R., Hastings, R., Covey, D. F., Reichert, D. E., Townsend, R. R. & Evers, A. S., Feb 2012, In: Electrophoresis. 33, 4, p. 666-674 9 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

A neurosteroid analogue with T-type calcium channel blocking properties is an effective hypnotic, but is not harmful to neonatal rat brain

Atluri, N., Joksimovic, S. M., Oklopcic, A., Milanovic, D., Klawitter, J., Eggan, P., Krishnan, K., Covey, D. F., Todorovic, S. M. & Jevtovic-Todorovic, V., Apr 2018, In: British journal of anaesthesia. 120, 4, p. 768-778 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

A new hypothesis based on suicide substrate inhibitor studies for the mechanism of action of aromatase

Covey, D. F. & Hood, W. F., 1982, In: Cancer research. 42, 8 Suppl., p. 3327s-3333s

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

A new method for the preparation of Ent-cholesterol from Ent- testosterone

Kumar, A. S. & Covey, D. F., Jan 29 1999, In: Tetrahedron Letters. 40, 5, p. 823-826 4 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

An improved synthesis of 18-nor-17-ketosteroids and application of the method for the preparation of (3β,5β,13α)- and (3β,5β,13β)-3-hydroxygonan-17-one

Han, M. & Covey, D. F., Oct 18 1996, In: Journal of Organic Chemistry. 61, 21, p. 7614-7616 3 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol

Iaea, D. B., Gale, S. E., Bielska, A. A., Krishnan, K., Fujiwara, H., Jiang, H., Maxfield, F. R., Schlesinger, P. H., Covey, D. F., Schaffer, J. E. & Ory, D. S., Dec 1 2015, In: Journal of lipid research. 56, 12, p. 2408-2419 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

A novel mechanism of non-feminizing estrogens in neuroprotection

Engler-Chiurazzi, E. B., Covey, D. F. & Simpkins, J. W., Aug 2017, In: Experimental Gerontology. 94, p. 99-102 4 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Antagonism of neurosteroid modulation of native γ-aminobutyric acid receptors by (3α,5α)-17-phenylandrost-16-en-3-ol

Kelley, S. P., Alan, J. K., O'Buckley, T. K., Mennerick, S., Krishnan, K., Covey, D. F. & Leslie Morrow, A., Oct 31 2007, In: European Journal of Pharmacology. 572, 2-3, p. 94-101 8 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light

Eisenman, L. N., Shu, H. J., Akk, G., Wang, C., Manion, B. D., Kress, G. J., Evers, A. S., Steinbach, J. H., Covey, D. F., Zorumski, C. F. & Mennerick, S., Apr 2007, In: Nature neuroscience. 10, 4, p. 523-530 8 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Anticonvulsant medications extend worm life-span

Evason, K., Huang, C., Yamben, I., Covey, D. F. & Kornfeld, K., Jan 14 2005, In: Science. 307, 5707, p. 258-262 5 p.

Research output: Contribution to journal › Article › peer-review

166 Scopus citations

Anticonvulsant potencies of the enantiomers of the neurosteroids androsterone and etiocholanolone exceed those of the natural forms

Zolkowska, D., Dhir, A., Krishnan, K., Covey, D. F. & Rogawski, M. A., Sep 2014, In: Psychopharmacology. 231, 17, p. 3325-3332 8 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Anticonvulsant properties of α-, γ-, and α,γ-substituted γ-butyrolactones

Klunk, W. E., Covey, D. F. & Ferrendelli, J. A., 1982, In: Molecular pharmacology. 22, 2, p. 438-443 6 p.

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

A Proinflammatory Stimulus Disrupts Hippocampal Plasticity and Learning via Microglial Activation and 25-Hydroxycholesterol

Izumi, Y., Cashikar, A. G., Krishnan, K., Paul, S. M., Covey, D. F., Mennerick, S. J. & Zorumski, C. F., Dec 8 2021, In: Journal of Neuroscience. 41, 49, p. 10054-10064 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

A rare example of extremely strong carbon—carbon coupling: Analysis of ¹³C and ¹H NMR spectra of a ¹³C₂‐acetylenic ketone

Auchus, R. J., d'Avignon, A. & Covey, D. F., May 1987, In: Magnetic Resonance in Chemistry. 25, 5, p. 462-465 4 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Aromatase enzyme catalysis is involved in the potent inhibition of estrogen biosynthesis caused by 4-acetoxy- and 4-hydroxy-4-androstene-3,17-dione

Covey, D. F. & Hood, W. F., 1982, In: Molecular pharmacology. 21, 1, p. 173-180 8 p.

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

A simple efficient synthesis of [23,24]-¹³C₂-labeled bile salts as NMR probes of protein-ligand interactions

Tochtrop, G. P., DeKoster, G. T., Cistola, D. P. & Covey, D. F., Feb 11 2002, In: Bioorganic and Medicinal Chemistry Letters. 12, 3, p. 433-435 3 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

A single hydroxyl group governs ligand site selectivity in human ileal bile acid binding protein

Tochtrop, G. P., DeKoster, G. T., Covey, D. F. & Cistola, D. P., Sep 8 2004, In: Journal of the American Chemical Society. 126, 35, p. 11024-11029 6 p.

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

A synthetic 18-norsteroid distinguishes between two neuroactive steroid binding sites on GABA_A receptors

Evers, A. S., Chen, Z. W., Manion, B. D., Han, M., Jiang, X., Darbandi-Tonkabon, R., Kable, T., Bracamontes, J., Zorumski, C. F., Mennerick, S., Steinbach, J. H. & Covey, D. F., May 2010, In: Journal of Pharmacology and Experimental Therapeutics. 333, 2, p. 404-413 10 p.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Binding and intracellular transport of 25-hydroxycholesterol by Niemann-Pick C2 protein

Petersen, D., Reinholdt, P., Szomek, M., Hansen, S. K., Poongavanam, V., Dupont, A., Heegaard, C. W., Krishnan, K., Fujiwara, H., Covey, D. F., Ory, D. S., Kongsted, J. & Wüstner, D., Feb 1 2020, In: Biochimica et Biophysica Acta - Biomembranes. 1862, 2, 183063.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Binding interactions of convulsant and anticonvulsant γ-butyrolactones and γ-thiobutyrolactones with the picrotoxin receptor

Holland, K. D., Mckeon, A. C., Covey, D. F. & Ferrendelli, J. A., 1990, In: Journal of Pharmacology and Experimental Therapeutics. 254, 2, p. 578-583 6 p.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Blockade of Ba²⁺ current through human α1E channels by two steroid analogs, (+)-ACN and (+)-ECN

Nakashima, Y. M., Pereverzev, A., Schneider, T., Covey, D. F. & Lingle, C. J., Jun 15 1999, In: Neuropharmacology. 38, 6, p. 843-855 13 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Carbon-13 Nuclear Magnetic Resonance Spectra of 5,10-Secosteroids. A Transannular Intramolecular Hydrogen Bond

Highet, R. J., Covey, D. F. & Robinson, C. H., Aug 1980, In: Journal of Organic Chemistry. 45, 16, p. 3286-3289 4 p.

Research output: Contribution to journal › Article › peer-review

Characteristics of concatemeric GABA _A receptors containing α4/δ subunits expressed in Xenopus oocytes

Shu, H. J., Bracamontes, J., Taylor, A., Wu, K., Eaton, M. M., Akk, G., Manion, B., Evers, A. S., Krishnan, K., Covey, D. F., Zorumski, C. F., Steinbach, J. H. & Mennerick, S., Apr 2012, In: British Journal of Pharmacology. 165, 7, p. 2228-2243 16 p.

Research output: Contribution to journal › Article › peer-review