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Research output per year
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Article
[19-14C]androstenedione: A new substrate for assaying aromatase and studying its reaction mechanism
Covey, D. F., McMullan, P. C., Wixler, L. L. & Cabell, M., Nov 30 1988, In: Biochemical and Biophysical Research Communications. 157, 1, p. 81-86 6 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
10β-Propynyl-substituted steroids. Mechanism-based enzyme-activated irreversible inhibitors to estrogen biosynthesis
Covey, D. F., Hood, W. F. & Parikh, V. D., 1981, In: Journal of Biological Chemistry. 256, 3, p. 1076-1079 4 p.Research output: Contribution to journal › Article › peer-review
133 Scopus citations -
11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: Potent general anesthetics and photolabeling reagents for GABAA receptors
Chen, Z. W., Wang, C., Krishnan, K., Manion, B. D., Hastings, R., Bracamontes, J., Taylor, A., Eaton, M. M., Zorumski, C. F., Steinbach, J. H., Akk, G., Mennerick, S., Covey, D. F. & Evers, A. S., Sep 2014, In: Psychopharmacology. 231, 17, p. 3479-3491 13 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
13C Nuclear Magnetic Resonance as a Monitor for Anionic Exchange Processes.1 Remote Epimerization via Homoenolate Ions and Aryl D Exchange
Hunter, D. H., Johnson, A. L., Stothers, J. B., Nickon, A., Lambert, J. L. & Covey, D. F., Nov 1 1972, In: Journal of the American Chemical Society. 94, 24, p. 8582-8584 3 p.Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner
Wong, M. Y., Lewis, M., Doherty, J. J., Shi, Y., Cashikar, A. G., Amelianchik, A., Tymchuk, S., Sullivan, P. M., Qian, M., Covey, D. F., Petsko, G. A., Holtzman, D. M., Paul, S. M., Paul, S. M. & Luo, W., Jun 17 2020, In: Journal of Neuroinflammation. 17, 1, 192.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
3,3-Dialkyl- and 3-alkyl-3-benzyl-substituted 2-pyrrolidinones: A new class of anticonvulsant agents
Reddy, P. A., Hsiang, B. C. H., Latifi, T. N., Hill, M. W., Woodward, K. E., Rothman, S. M., Ferrendelli, J. A. & Covey, D. F., Apr 26 1996, In: Journal of Medicinal Chemistry. 39, 9, p. 1898-1906 9 p.Research output: Contribution to journal › Article › peer-review
80 Scopus citations -
3β-Hydroxypregnane Steroids Are Pregnenolone Sulfate-Like GABA A Receptor Antagonists
Wang, M., He, Y., Eisenman, L. N., Fields, C., Zeng, C. M., Mathews, J., Benz, A., Fu, T., Zorumski, E., Steinbach, J. H., Covey, D. F., Zorumski, C. F. & Mennerick, S., May 1 2002, In: Journal of Neuroscience. 22, 9, p. 3366-3375 10 p.Research output: Contribution to journal › Article › peer-review
Open Access130 Scopus citations -
4β-Hydroxycholesterol is a prolipogenic factor that promotes SREBP1c expression and activity through the liver X receptor
Moldavski, O., Zushin, P. J. H., Berdan, C. A., Van Eijkeren, R. J., Jiang, X., Qian, M., Ory, D. S., Covey, D. F., Nomura, D. K., Stahl, A., Weiss, E. J. & Zoncu, R., 2021, In: Journal of lipid research. 62, 100051.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
5α-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic pain
Pathirathna, S., Todorovic, S. M., Covey, D. F. & Jevtovic-Todorovic, V., Oct 2005, In: Pain. 117, 3, p. 326-339 14 p.Research output: Contribution to journal › Article › peer-review
61 Scopus citations -
5β-Reduced neuroactive steroids are novel voltage-dependent blockers of T-type Ca2+ channels in rat sensory neurons in vitro and potent peripheral analgesics in vivo
Todorovic, S. M., Pathirathna, S., Brimelow, B. C., Jagodic, M. M., Ko, S. H., Jiang, X., Nilsson, K. R., Zorumski, C. F., Covey, D. F. & Jevtovic-Todorovic, V., Nov 2004, In: Molecular pharmacology. 66, 5, p. 1223-1235 13 p.Research output: Contribution to journal › Article › peer-review
66 Scopus citations -
Abnormal Beckmann fragmentation/ring closing metathesis route for preparation of 18-nor-Δ13(17)-androgens and their 18-nor-13,17-epoxide derivatives
Wang, C., Rath, N. P. & Covey, D. F., Nov 6 2006, In: Tetrahedron Letters. 47, 45, p. 7837-7839 3 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Acid Homoketonization with Inversion of Configuration. Dramatic Effect of Water in Control of Stereochemistry
Nickon, A., Frank, J. J., Covey, D. F. & Lin, Y. I., Nov 1 1974, In: Journal of the American Chemical Society. 96, 24, p. 7574-7576 3 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
A clickable neurosteroid photolabel reveals selective Golgi compartmentalization with preferential impact on proximal inhibition
Jiang, X., Shu, H. J., Krishnan, K., Qian, M., Taylor, A. A., Covey, D. F., Zorumski, C. F. & Mennerick, S., Sep 1 2016, In: Neuropharmacology. 108, p. 193-206 14 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
A Clickable Oxysterol Photolabel Retains NMDA Receptor Activity and Accumulates in Neurons
Chen, D. M., Ziolkowski, L., Benz, A., Qian, M., Zorumski, C. F., Covey, D. F. & Mennerick, S., Dec 6 2018, In: Frontiers in Neuroscience. 12, 923.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Additive neuroprotective effects of 24(S)-hydroxycholesterol and allopregnanolone in an ex vivo rat glaucoma model
Ishikawa, M., Yoshitomi, T., Covey, D. F., Zorumski, C. F. & Izumi, Y., Dec 1 2018, In: Scientific reports. 8, 1, 12851.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
A facile total synthesis of ent-17β-estradiol and structurally related analogues
Cai, Z. Y. & Covey, D. F., Apr 2007, In: Steroids. 72, 4, p. 351-359 9 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Affinity Labeling of Human Placental 3β-Hydroxy-Δ5-steroid Dehydrogenase and Steroid-Isomerase: Evidence for Bifunctional Catalysis by a Different Conformation of the Same Protein for Each Enzyme Activity
Thomas, J. L., Strickler, R. C., Myers, R. P. & Covey, D. F., Feb 1 1992, In: Biochemistry. 31, 24, p. 5522-5527 6 p.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
Aggregate formation from 3-alkylindoles: Amphiphilic models for interfacial helix anchoring groups
Abel, E., De Wall, S. L., Edwards, W. B., Lalitha, S., Covey, D. F. & Gokel, G. W., Mar 21 2000, In: Chemical Communications. 6, p. 433-434 2 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Alkyl-Substituted Thiolo-, Thiono-, and Dithio-γ-butyrolactones: New Classes of Convulsant and Anticonvulsant Agents
Levine, J. A., Ferrendelli, J. A. & Covey, D. F., 1986, In: Journal of Medicinal Chemistry. 29, 10, p. 1996-1999 4 p.Research output: Contribution to journal › Article › peer-review
33 Scopus citations -
Alkyl-substituted γ-butyrolactones act at a distinct site allosterically linked to the TBPS/picrotoxinin site on the GABAA receptor complex
Holland, K. D., Bouley, M. G., Covey, D. F. & Ferrendelli, J. A., Jun 25 1993, In: Brain Research. 615, 1, p. 170-174 5 p.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
Alkyl-substituted γ-butyrolactones as potential tools in the study and treatment of epilepsy
Klunk, W. E., Covey, D. F. & Ferrendelli, J. A., Oct 15 1983, In: Biochemical Pharmacology. 32, 20, p. 2999-3004 6 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Alpha-substituted γ-butyrolactones: New class of anticonvulsant drugs
Klunk, W. E., McKeon, A. C., Covey, D. F. & Ferrendelli, J. A., 1982, In: Science. 217, 4564, p. 1040-1042 3 p.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
Analysis of GABAA receptor activation by combinations of agonists acting at the same or distinct binding sites
Shin, D. J., Germann, A. L., Covey, D. F., Steinbach, J. H. & Akk, G., Jan 2019, In: Molecular pharmacology. 95, 1, p. 70-81 12 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
A neuroactive steroid with a therapeutically interesting constellation of actions at GABAA and NMDA receptors
Ziolkowski, L., Mordukhovich, I., Chen, D. M., Chisari, M., Shu, H. J., Lambert, P. M., Qian, M., Zorumski, C. F., Covey, D. F. & Mennerick, S., Feb 1 2021, In: Neuropharmacology. 183, 108358.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
A neurosteroid analogue photolabeling reagent labels the colchicine-binding site on tubulin: A mass spectrometric analysis
Chen, Z. W., Chen, L. H., Akentieva, N., Lichti, C. F., Darbandi, R., Hastings, R., Covey, D. F., Reichert, D. E., Townsend, R. R. & Evers, A. S., Feb 2012, In: Electrophoresis. 33, 4, p. 666-674 9 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
A neurosteroid analogue with T-type calcium channel blocking properties is an effective hypnotic, but is not harmful to neonatal rat brain
Atluri, N., Joksimovic, S. M., Oklopcic, A., Milanovic, D., Klawitter, J., Eggan, P., Krishnan, K., Covey, D. F., Todorovic, S. M. & Jevtovic-Todorovic, V., Apr 2018, In: British journal of anaesthesia. 120, 4, p. 768-778 11 p.Research output: Contribution to journal › Article › peer-review
22 Scopus citations -
A new hypothesis based on suicide substrate inhibitor studies for the mechanism of action of aromatase
Covey, D. F. & Hood, W. F., 1982, In: Cancer research. 42, 8 Suppl., p. 3327s-3333sResearch output: Contribution to journal › Article › peer-review
76 Scopus citations -
A new method for the preparation of Ent-cholesterol from Ent- testosterone
Kumar, A. S. & Covey, D. F., Jan 29 1999, In: Tetrahedron Letters. 40, 5, p. 823-826 4 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
An improved synthesis of 18-nor-17-ketosteroids and application of the method for the preparation of (3β,5β,13α)- and (3β,5β,13β)-3-hydroxygonan-17-one
Han, M. & Covey, D. F., Oct 18 1996, In: Journal of Organic Chemistry. 61, 21, p. 7614-7616 3 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol
Iaea, D. B., Gale, S. E., Bielska, A. A., Krishnan, K., Fujiwara, H., Jiang, H., Maxfield, F. R., Schlesinger, P. H., Covey, D. F., Schaffer, J. E. & Ory, D. S., Dec 1 2015, In: Journal of lipid research. 56, 12, p. 2408-2419 12 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
A novel mechanism of non-feminizing estrogens in neuroprotection
Engler-Chiurazzi, E. B., Covey, D. F. & Simpkins, J. W., Aug 2017, In: Experimental Gerontology. 94, p. 99-102 4 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Antagonism of neurosteroid modulation of native γ-aminobutyric acid receptors by (3α,5α)-17-phenylandrost-16-en-3-ol
Kelley, S. P., Alan, J. K., O'Buckley, T. K., Mennerick, S., Krishnan, K., Covey, D. F. & Leslie Morrow, A., Oct 31 2007, In: European Journal of Pharmacology. 572, 2-3, p. 94-101 8 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light
Eisenman, L. N., Shu, H. J., Akk, G., Wang, C., Manion, B. D., Kress, G. J., Evers, A. S., Steinbach, J. H., Covey, D. F., Zorumski, C. F. & Mennerick, S., Apr 2007, In: Nature neuroscience. 10, 4, p. 523-530 8 p.Research output: Contribution to journal › Article › peer-review
20 Scopus citations -
Anticonvulsant medications extend worm life-span
Evason, K., Huang, C., Yamben, I., Covey, D. F. & Kornfeld, K., Jan 14 2005, In: Science. 307, 5707, p. 258-262 5 p.Research output: Contribution to journal › Article › peer-review
161 Scopus citations -
Anticonvulsant potencies of the enantiomers of the neurosteroids androsterone and etiocholanolone exceed those of the natural forms
Zolkowska, D., Dhir, A., Krishnan, K., Covey, D. F. & Rogawski, M. A., Sep 2014, In: Psychopharmacology. 231, 17, p. 3325-3332 8 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Anticonvulsant properties of α-, γ-, and α,γ-substituted γ-butyrolactones
Klunk, W. E., Covey, D. F. & Ferrendelli, J. A., 1982, In: Molecular pharmacology. 22, 2, p. 438-443 6 p.Research output: Contribution to journal › Article › peer-review
38 Scopus citations -
A rare example of extremely strong carbon—carbon coupling: Analysis of 13C and 1H NMR spectra of a 13C2‐acetylenic ketone
Auchus, R. J., d'Avignon, A. & Covey, D. F., May 1987, In: Magnetic Resonance in Chemistry. 25, 5, p. 462-465 4 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Aromatase enzyme catalysis is involved in the potent inhibition of estrogen biosynthesis caused by 4-acetoxy- and 4-hydroxy-4-androstene-3,17-dione
Covey, D. F. & Hood, W. F., 1982, In: Molecular pharmacology. 21, 1, p. 173-180 8 p.Research output: Contribution to journal › Article › peer-review
77 Scopus citations -
A simple efficient synthesis of [23,24]-13C2-labeled bile salts as NMR probes of protein-ligand interactions
Tochtrop, G. P., DeKoster, G. T., Cistola, D. P. & Covey, D. F., Feb 11 2002, In: Bioorganic and Medicinal Chemistry Letters. 12, 3, p. 433-435 3 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
A single hydroxyl group governs ligand site selectivity in human ileal bile acid binding protein
Tochtrop, G. P., DeKoster, G. T., Covey, D. F. & Cistola, D. P., Sep 8 2004, In: Journal of the American Chemical Society. 126, 35, p. 11024-11029 6 p.Research output: Contribution to journal › Article › peer-review
50 Scopus citations -
A synthetic 18-norsteroid distinguishes between two neuroactive steroid binding sites on GABAA receptors
Evers, A. S., Chen, Z. W., Manion, B. D., Han, M., Jiang, X., Darbandi-Tonkabon, R., Kable, T., Bracamontes, J., Zorumski, C. F., Mennerick, S., Steinbach, J. H. & Covey, D. F., May 2010, In: Journal of Pharmacology and Experimental Therapeutics. 333, 2, p. 404-413 10 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Binding and intracellular transport of 25-hydroxycholesterol by Niemann-Pick C2 protein
Petersen, D., Reinholdt, P., Szomek, M., Hansen, S. K., Poongavanam, V., Dupont, A., Heegaard, C. W., Krishnan, K., Fujiwara, H., Covey, D. F., Ory, D. S., Kongsted, J. & Wüstner, D., Feb 1 2020, In: Biochimica et Biophysica Acta - Biomembranes. 1862, 2, 183063.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Binding interactions of convulsant and anticonvulsant γ-butyrolactones and γ-thiobutyrolactones with the picrotoxin receptor
Holland, K. D., Mckeon, A. C., Covey, D. F. & Ferrendelli, J. A., 1990, In: Journal of Pharmacology and Experimental Therapeutics. 254, 2, p. 578-583 6 p.Research output: Contribution to journal › Article › peer-review
27 Scopus citations -
Blockade of Ba2+ current through human α1E channels by two steroid analogs, (+)-ACN and (+)-ECN
Nakashima, Y. M., Pereverzev, A., Schneider, T., Covey, D. F. & Lingle, C. J., Jun 15 1999, In: Neuropharmacology. 38, 6, p. 843-855 13 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Carbon-13 Nuclear Magnetic Resonance Spectra of 5,10-Secosteroids. A Transannular Intramolecular Hydrogen Bond
Highet, R. J., Covey, D. F. & Robinson, C. H., Aug 1980, In: Journal of Organic Chemistry. 45, 16, p. 3286-3289 4 p.Research output: Contribution to journal › Article › peer-review
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Characteristics of concatemeric GABA A receptors containing α4/δ subunits expressed in Xenopus oocytes
Shu, H. J., Bracamontes, J., Taylor, A., Wu, K., Eaton, M. M., Akk, G., Manion, B., Evers, A. S., Krishnan, K., Covey, D. F., Zorumski, C. F., Steinbach, J. H. & Mennerick, S., Apr 2012, In: British Journal of Pharmacology. 165, 7, p. 2228-2243 16 p.Research output: Contribution to journal › Article › peer-review
Open Access41 Scopus citations -
Characterization of enantiomeric bile acid-induced apoptosis in colon cancer cell lines
Katona, B. W., Anant, S., Covey, D. F. & Stenson, W. F., Jan 30 2009, In: Journal of Biological Chemistry. 284, 5, p. 3354-3364 11 p.Research output: Contribution to journal › Article › peer-review
Open Access52 Scopus citations -
Characterization of pregnant mare's serum gonadotropin-stimulated rat ovarian aromatase and its inhibition by 10-propargylestr-4-ene-3,17-dione
Brandt, M. E., Puett, D., Covey, D. F. & Zimniski, S. J., Sep 1988, In: Journal of Steroid Biochemistry. 31, 3, p. 317-324 8 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Chirality in Membranes: First Evidence that Enantioselective Interactions Between Cholesterol and Cell Membrane Lipids Can Be a Determinant of Membrane Physical Properties
Lalitha, S., Sampath Kumar, A., Stine, K. J. & Covey, D. F., Mar 2001, In: Journal of Supramolecular Chemistry. 1, 2, p. 53-61 9 p.Research output: Contribution to journal › Article › peer-review
38 Scopus citations -
Cholesterol accessibility at the ciliary membrane controls hedgehog signaling
Kinnebrew, M., Iverson, E. J., Patel, B. B., Pusapati, G. V., Kong, J. H., Johnson, K. A., Luchetti, G., Eckert, K. M., McDonald, J. G., Covey, D. F., Siebold, C., Radhakrishnan, A. & Rohatgi, R., Oct 2019, In: eLife. 8, e50051.Research output: Contribution to journal › Article › peer-review
Open Access40 Scopus citations