Research output per year
Research output per year
Personal profile
Research interests
The centralized goal in my research group involves the discovery of new small molecules that can be used to interrogate biological pathways associated with human diseases. We use a combination of structure-based design, in silico modeling, and AI-driven technologies to identify hits for further downstream optimization related to potency, selectivity, and ADME/DMPK properties. Therapeutic areas we are currently involved with include malignancies associated with ion channel biology, oncology, and infectious diseases.
Available to Mentor:
- PhD Students
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Collaborations and top research areas from the last five years
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Ni-Catalyzed Cyanation of (Hetero)Aryl Electrophiles Using the Nontoxic Cyanating Reagent K4[Fe(CN)6]
Wilson, N. A., Palmer, W. M., Slimp, M. K., Simmons, E. M., Joannou, M. V., Albaneze-Walker, J., Ganley, J. M. & Frantz, D. E., Apr 18 2025, In: ACS Catalysis. 15, 8, p. 6459-6465 7 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Pharmacokinetic and Biodistribution Studies of [18F]-Taccalonolide: A Covalent Microtubule Stabilizer with Antitumor Efficacy
Jaskowski, L. N., Clanton, N. A., Wilkinson, N. J., Bartels, J. L., LoCoco, P. M., Frantz, A. N., Boyer, A. D., Boerma, J. W., Bush, J. E. M., Brown, S. D., Fernandez, K., Archer, N. E., Tekin, V., Fernandez, S. R., Risinger, A. L., Frantz, D. E. & Lapi, S. E., Aug 14 2025, In: ACS Medicinal Chemistry Letters. 16, 8, p. 1569-1574 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Palladium-Catalyzed Cyanations of Aryl Imidazolylsulfonates with K 4[Fe(CN) 6]: A Pragmatic Approach to Benzonitriles from Phenols
Wilson, N. A., Palmer, W. M., Ganley, J. M., Coombs, J. R., Levorse, M. S., Albaneze-Walker, J. & Frantz, D. E., 2024, (Accepted/In press) In: Synthesis.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
General Method for Ni-Catalyzed C-N Cross-Couplings of (Hetero)Aryl Chlorides with Anilines and Aliphatic Amines under Homogeneous Conditions Using a Dual-Base Strategy
Villatoro, R. S., Belfield, J. R., Arman, H. D., Hernandez, L. W., Simmons, E. M., Garlets, Z. J., Wisniewski, S. R., Coombs, J. R. & Frantz, D. E., Nov 13 2023, In: Organometallics. 42, 21, p. 3164-3172 9 p.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
Site-Selective Functionalization of Unactivated Allylic C-H Bonds via Direct Deprotonation with KTMP: Application to the Formal Total Synthesis of (+)-Artemisinin from Amorphadiene
Clanton, N. A., Wilson, N. A., Ortiz, E., Blumberg, S. T. & Frantz, D. E., Jan 13 2023, In: Organic Letters. 25, 1, p. 277-281 5 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations