Personal profile
Research interests
Dr. Njoku is an internationally respected basic/translational researcher in immune-mediated liver injury. The objective of the Njoku Lab is to discover mechanisms associated with susceptibility to immune mediated hepatitis in all of its forms. Her laboratory investigates the basis of sex differences in drug-induced, immune-mediated liver disease. The Njoku Lab has characterized the mechanisms by which cytokines, CD4+T cells, B cells and FoxP3+T cells contribute to this form of hepatitis, triggered by an epitope of cytochrome P450 2E1 using an in vivo mouse model.
The Njoku Lab also investigates metabolic liver disease and its sequelae, specifically hormonal factors associated with fatty acid biosynthesis as well as uptake and distribution utilizing immunological, metabolic and genetic techniques.
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Collaborations and top research areas from the last five years
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Editorial
Njoku, D. B., Jun 1 2025, In: Current Opinion in Anaesthesiology. 38, 3, p. 215-216 2 p.Research output: Contribution to journal › Editorial
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Anaesthesia for children with congenital heart disease undergoing non-cardiac surgery
Spiro, J., Bauerle, J. & Njoku, D., Dec 2024, In: BJA Education. 24, 12, p. 458-467 10 p.Research output: Contribution to journal › Review article › peer-review
Open Access5 Link opens in a new tab Scopus citations -
Elevated preoperative blood pressure and its relationship to intraoperative mean arterial pressure and blood loss in posterior spinal fusion for adolescent idiopathic scoliosis
Prasad, N., Jain, A., Bronheim, R. S., Marrache, M., Njoku, D. B. & Sponseller, P. D., Jan 2024, In: European Journal of Orthopaedic Surgery and Traumatology. 34, 1, p. 339-345 7 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations -
Gastrointestinal and Hepatic Physiology, Pathophysiology, and Anesthetic Considerations
Njoku, D. B., Drobish, J. K., Kronish, K. & Chitilian, H. V., Jan 1 2024, Miller's Anesthesia, 2 Volume Set. Elsevier, Vol. 1-2. p. 293-328.e8Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Sexual dimorphism in hepatic PPAR alpha and CYP4a12a expression is associated with reduced development of drug-induced non-alcoholic steatohepatitis in female IL-33−/− mice
Thomas, C. & Njoku, D. B., 2024, In: Frontiers in Medicine. 11, 1425528.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Scopus citations