Personal profile
Research interests
My research interests focus on the molecular and cellular mechanisms of metabolic disease induced by nutrient overload. I study the pleiotropic effects of lipids and carbohydrates on signal transduction and energy metabolism. My main goal is to translate my findings from cultured cells and rodent models of metabolic disease to controlled studies on the pathogenesis of insulin resistance and type II diabetes in humans.
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Collaborations and top research areas from the last five years
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Immune cells regulate circulating adipocyte extracellular vesicle levels in response to metabolic shifts
Tiash, S., Patel, S. A., Russo, M., Suresh, A., Pang, B., Pai, Y. L., Jia, W., Field, R. L., Pietka, T., Abumrad, N. A., Smith, G. I., Samovski, D., Klein, S., Brestoff, J. R. & Crewe, C., May 5 2026, In: Cell metabolism. 38, 5, p. 929-943.e8Research output: Contribution to journal › Article › peer-review
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Adipose Tissue Biology and Effect of Weight Loss in Women With Lipedema
Cifarelli, V., Smith, G. I., Gonzalez-Nieves, S., Samovski, D., Palacios, H. H., Yoshino, J., Stein, R. I., Fuchs, A., Wright, T. F. & Klein, S., Mar 2025, In: Diabetes. 74, 3, p. 308-319 12 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Link opens in a new tab Scopus citations -
Effect of Marked Weight Loss on Adipose Tissue Biology in People With Obesity and Type 2 Diabetes
Samovski, D., Smith, G. I., Palacios, H., Pietka, T., Fuchs, A., Patti, G. J., Nawaz, A., Ronald Kahn, C. & Klein, S., Aug 2025, In: Diabetes care. 48, 8, p. 1342-1351 10 p.Research output: Contribution to journal › Article › peer-review
10 Link opens in a new tab Scopus citations -
Impaired suppression of fatty acid release by insulin is a strong predictor of reduced whole-body insulin-mediated glucose uptake and skeletal muscle insulin receptor activation
Schleh, M. W., Ryan, B. J., Ahn, C., Ludzki, A. C., Van Pelt, D. W., Pitchford, L. M., Chugh, O. K., Luker, A. T., Luker, K. E., Samovski, D., Abumrad, N. A., Burant, C. F. & Horowitz, J. F., Jan 2025, In: Acta Physiologica. 241, 1, e14249.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations -
Microvascular insulin resistance with enhanced muscle glucose disposal in CD36 deficiency
Shibao, C. A., Peche, V. S., Pietka, T. A., Samovski, D., Williams, I. M., Abumrad, N. N., Gamazon, E. R., Goldberg, I. J., Wasserman, D. H. & Abumrad, N. A., Mar 2025, In: Diabetologia. 68, 3, p. 662-675 14 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Link opens in a new tab Scopus citations