Personal profile
Research interests
Brain tumors are devastating for the individuals affected and present a challenge for the doctors taking care of them. Despite the technological and surgical advancements, many patients succumb to their disease and others have serious side effects related to their treatments. With my expertise in Cancer Immunology, Genetics and Epigenetics, I have applied these tools towards the development of treatments before they become symptomatic, and at a point when they are easily resectable or curable with other treatments that could lead to improved outcomes. The Molecular Neuro-oncology lab is focused on developing genomic and epigenomic approaches for the development of liquid biopsy assays for non-invasive detection of brain tumors. The work performed is multidisciplinary and includes physicians, molecular biologists, and bioinformaticians.
Clinical interests
Brain tumors Gliobastoma and other gliomas Ependymomas Meningiomas Orbital tumors Intraventricular tumors Hydrocephalus
Available to Mentor:
- PhD Students
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Collaborations and top research areas from the last five years
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Cell-free DNA fragmentomes for noninvasive detection of liver cirrhosis and other diseases
Annapragada, A. V., Foda, Z. H., Orjuela, H., Norton, C., Koul, S., Niknafs, N., Short, S., Boyapati, K., Bartolomucci, A., Mathios, D., Noë, M., Cherry, C., Carey, J., Leal, A., Chesnick, B., Dracopoli, N. C., Medina, J. E., Vulpescu, N. A., Bruhm, D. C. & Bacus, S. & 17 others, , Mar 4 2026, In: Science translational medicine. 18, 839, eadw2603.Research output: Contribution to journal › Article › peer-review
1 Link opens in a new tab Scopus citations -
Case report: Molecular characterization of adult atypical teratoid rhabdoid tumor and review of the literature
Hernandez-Rovira, M. A., Connor, M., Osorio, R. C., Russler-Germain, E., Schmidt, R., Johnson, G. W., Silverstein, J., Dahiya, S., Farrell, N. F., Weiss, M. C., Zipfel, G. J., Huang, J. & Mathios, D., 2025, In: Frontiers in Oncology. 15, 1510439.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations -
Detection of Brain Cancer Using Genome-wide Cell-free DNA Fragmentomes
Mathios, D., Niknafs, N., Annapragada, A. V., Bobeff, E. J., Chiao, E. J., Boyapati, K., Boyapati, K., Short, S., Bartolomucci, A. L., Cristiano, S., Koul, S., Vulpescu, N. A., Ferreira, L., Medina, J. E., Bruhm, D. C., Adleff, V., Podstawka, M., Stanisławska, P., Park, C. K. & Huang, J. & 10 others, , Aug 1 2025, In: Cancer discovery. 15, 8, p. 1593-1608 16 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Link opens in a new tab Scopus citations -
Diffusely metastatic glioblastoma with FGFR3::TACC3 fusion: cell-free DNA fragmentation analyses and molecular characterization of matched primary and metastatic tumor sites
Hernandez-Rovira, M. A., Vagnozzi, A., Bales, T., Prabhu, K. N., Niknafs, N., Chheda, M., Huang, J., Kim, A. H., Miller-Thomas, M., Butt, O., Vo, K. D., Sovani, B. S., Parihar, A. S., Crumley, S., Dahiya, S. & Mathios, D., Dec 2025, In: Acta Neuropathologica Communications. 13, 1, 221.Research output: Contribution to journal › Article › peer-review
Open Access -
Early Detection of Ovarian Cancer Using Cell-Free DNA Fragmentomes and Protein Biomarkers
Medina, J. E., Annapragada, A. V., Lof, P., Short, S., Bartolomucci, A. L., Mathios, D., Koul, S., Niknafs, N., Noë, M., Foda, Z. H., Bruhm, D. C., Hruban, C., Vulpescu, N. A., Jung, E., Dua, R., Canzoniero, J. V., Cristiano, S., Adleff, V., Symecko, H. & van den Broek, D. & 15 others, , Jan 1 2025, In: Cancer discovery. 15, 1, p. 105-118 14 p.Research output: Contribution to journal › Article › peer-review
Open Access41 Link opens in a new tab Scopus citations