Research output per year
Research output per year
Personal profile
Research interests
Brain tumors are devastating for the individuals affected and present a challenge for the doctors taking care of them. Despite the technological and surgical advancements, many patients succumb to their disease and others have serious side effects related to their treatments. With my expertise in Cancer Immunology, Genetics and Epigenetics, I have applied these tools towards the development of treatments before they become symptomatic, and at a point when they are easily resectable or curable with other treatments that could lead to improved outcomes. The Molecular Neuro-oncology lab is focused on developing genomic and epigenomic approaches for the development of liquid biopsy assays for non-invasive detection of brain tumors. The work performed is multidisciplinary and includes physicians, molecular biologists, and bioinformaticians.
Clinical interests
Brain tumors Gliobastoma and other gliomas Ependymomas Meningiomas Orbital tumors Intraventricular tumors Hydrocephalus
Available to Mentor:
- PhD/MSTP Students
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Collaborations and top research areas from the last five years
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Case report: Molecular characterization of adult atypical teratoid rhabdoid tumor and review of the literature
Hernandez-Rovira, M. A., Connor, M., Osorio, R. C., Russler-Germain, E., Schmidt, R., Johnson, G. W., Silverstein, J., Dahiya, S., Farrell, N. F., Weiss, M. C., Zipfel, G. J., Huang, J. & Mathios, D., 2025, In: Frontiers in Oncology. 15, 1510439.Research output: Contribution to journal › Article › peer-review
Open Access -
Early Detection of Ovarian Cancer Using Cell-Free DNA Fragmentomes and Protein Biomarkers
Medina, J. E., Annapragada, A. V., Lof, P., Short, S., Bartolomucci, A. L., Mathios, D., Koul, S., Niknafs, N., Noë, M., Foda, Z. H., Bruhm, D. C., Hruban, C., Vulpescu, N. A., Jung, E., Dua, R., Canzoniero, J. V., Cristiano, S., Adleff, V., Symecko, H. & van den Broek, D. & 15 others, , Jan 1 2025, In: Cancer discovery. 15, 1, p. 105-118 14 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
DNA methylation and gene expression as determinants of genome-wide cell-free DNA fragmentation
Noë, M., Mathios, D., Annapragada, A. V., Koul, S., Foda, Z. H., Medina, J. E., Cristiano, S., Cherry, C., Bruhm, D. C., Niknafs, N., Adleff, V., Ferreira, L., Easwaran, H., Baylin, S., Phallen, J., Scharpf, R. B. & Velculescu, V. E., Dec 2024, In: Nature communications. 15, 1, 6690.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Genome-wide repeat landscapes in cancer and cell-free DNA
Annapragada, A. V., Niknafs, N., White, J. R., Bruhm, D. C., Cherry, C., Medina, J. E., Adleff, V., Hruban, C., Mathios, D., Foda, Z. H., Phallen, J., Scharpf, R. B. & Velculescu, V. E., Mar 13 2024, In: Science translational medicine. 16, 738, eadj9283.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Innovation in Non-Invasive Diagnosis and Disease Monitoring for Meningiomas
Korte, B. & Mathios, D., Apr 2024, In: International journal of molecular sciences. 25, 8, 4195.Research output: Contribution to journal › Review article › peer-review
Open Access4 Scopus citations