• 3113 Citations
1988 …2020

Research output per year

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Personal profile

Research interests

1. The complement system is a first line of defense of the intravascular space: Complement rapidly recognizes foreign entities and marks them for clearance and/or lysis. Many pathogens have evolved systems to avoid complement-activity. We are focusing on novel strategies to direct complement-dependent clearance of complement-resistant and antibiotic-resistant Gram-negative bacteria. 2. We are very interested understanding the mechanism of Retinal Vasculopathy with Cerebral Leukoencephalopathy and Systemic Manifestations (RVCL-S), a rare monogenic condition that results in late onset cognitive and visual dysfunction and death. RVCL-S is caused by dominant frameshift mutations in Trex1, a gene that encodes a 3' DNA exonuclease normally tethered to the ER with the nuclease domain facing the cytosol. The RVCL-S associated mutations produce a functional exonuclease that is misplaced in the cell nucleus and likely impairs the DNA damage response and genome stability.

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Research Output

  • 3113 Citations
  • 52 Article
  • 3 Review article
  • 1 Comment/debate
  • 1 Letter

Deep phenotyping detects a pathological CD4+ T-cell complosome signature in systemic sclerosis

Arbore, G., Ong, V. H., Costantini, B., Denton, C. P., Abraham, D., Placais, L., Blighe, K., Mitchell, L., Ellis, R., Heck, S., Nocerino, P., Woodruff, T. M., Kordasti, S., Kemper, C. & Hourcade, D. E., Jan 1 2020, (Accepted/In press) In : Cellular and Molecular Immunology.

Research output: Contribution to journalLetter

Complement activation on neutrophils initiates endothelial adhesion and extravasation

Akk, A., Springer, L. E., Yang, L., Hamilton-Burdess, S., Lambris, J. D., Yan, H., Hu, Y., Wu, X., Hourcade, D. E., Miller, M. J. & Pham, C. T. N., Oct 2019, In : Molecular Immunology. 114, p. 629-642 14 p.

Research output: Contribution to journalArticle

  • 1 Scopus citations

    Contribution of adipose-derived factor D/Adipsin to complement alternative pathway activation: Lessons from lipodystrophy

    Wu, X., Hutson, I., Akk, A. M., Mascharak, S., Pham, C. T. N., Hourcade, D. E., Brown, R., Atkinson, J. P. & Harris, C. A., Apr 15 2018, In : Journal of Immunology. 200, 8, p. 2786-2797 12 p.

    Research output: Contribution to journalArticle

  • 14 Scopus citations

    Timing and mechanism of conceptus demise in a complement regulatory membrane protein deficient mouse

    Triebwasser, M. P., Wu, X., Bertram, P., Hourcade, D. E., Nelson, D. M. & Atkinson, J. P., Oct 2018, In : American Journal of Reproductive Immunology. 80, 4, e12997.

    Research output: Contribution to journalArticle

    Open Access
  • Annexin A2 Enhances complement activation by inhibiting factor H

    Renner, B., Tong, H. H., Laskowski, J., Jonscher, K., Goetz, L., Woolaver, R., Hannan, J., Li, Y. X., Hourcade, D., Pickering, M. C., Michael Holers, V. & Thurman, J. M., Feb 1 2016, In : Journal of Immunology. 196, 3, p. 1355-1365 11 p.

    Research output: Contribution to journalArticle

    Open Access
  • 5 Scopus citations