Willing to Mentor

    Available to Mentor:

    Undergraduate Students, Post-Baccalaureate Students, PhD/MSTP Students, Health Professions (Medical, OT, PT, Dental, Audiology, etc.) Students, Postdocs, Residents and Fellows

    • Source: Scopus
    1986 …2021

    Research activity per year

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    Personal profile

    Research interests

    My laboratory studies the differentiation of osteoclasts, particularly in the context of pathological bone loss, such as in osteoporosis, inflammatory arthritis, and cancer metastasis to bone. Osteoclasts are derived from hematopoietic progenitors in the myeloid lineage, under the influence of the TNF family cytokine RANKL. The binding of RANKL to its receptor RANK activates a number of signaling pathways, including NF-?B, MAPKs, and PI3K/Akt. Our current focus is on the NF-?B pathway, and the role of the various NF-?B family members, inhibitors, and regulatory kinases. It has recently been established that there are 2 main NF-?B pathways, the classical pathway activated rapidly by the IKK complex, leading to translocation of p65/p50 heterodimers, and an alternative pathway controlled by NIK, leading to slower accumulation of RelB/p52 complexes. Blockade of both NF-?B pathways abolishes osteoclast differentiation at a very early stage. We are now dissecting the role of these two pathways using multiple knockout mouse models, with in vitro models of osteoclast differentiation and in vivo models of pathological bone loss. Current projects include: 1) the role of NIK in inflammatory arthritis, 2) the mechanism by which the NF-?B subunit RelB enhances osteoclastogenesis, 3) the role of p65 in osteoclast progenitors, and 4) the importance of NF-?B pathways in bone metastasis.

    Mentoring

    I am interested in mentoring undergraduates, post-bac students, graduate students, postdocs, or residents and fellows with appropriate interests in bone, infection, and/or cancer. The Musculoskeletal Research Center, in which the Veis lab is located, provides a rich training environment to complement experiences within the lab, including many active collaborations.

    Available to Mentor:

    • Undergraduate Students
    • Post-Baccalaureate Students
    • PhD/MSTP Students
    • Health Professions Students
    • Postdocs
    • Residents and Fellows

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