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Deborah Lenschow

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Deborah Lenschow

John S. Daniels Professorship, Professor of Medicine, Professor of Molecular Microbiology, Professor of Pathology and Immunology

 https://orcid.org/0000-0002-9400-5309

    Willing to Mentor

    Available to Mentor:

    PhD Students

    • 16219
      Citations
    1992 …2026

    Research activity per year

    Personal profile

    Research interests

    Type I interferons are a class of cytokines that regulate numerous biological pathways, including the induction of a host antiviral state, regulation of apoptosis, inhibition of cell growth, and modulation of both the innate and adaptive immune responses. Interferons mediate these activities through the induction of hundred of gene products known as interferon stimulated genes (ISGs). We are interested in identifying novel ISGs that function to modulate the host anti-viral response, the innate and adaptive immune response, and their role in the development of autoimmunity.

    Clinical interests

    Rheumatology

    Available to Mentor:

    • PhD Students

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    • ISG15 negatively regulates RIPK3-mediated cell death and viral pathogenesis

      Perng, Y. C., Warsaw, J. M. C., Bais, S. S., Hiller, B. E., Locke, M. C., Morales-Heil, D. J., Li, C., Young, A. R., Monte, K. J., Schmidt, R. E., Green, D. R., Gong, Y. N. & Lenschow, D. J., May 26 2026, In: Cell Reports. 45, 5, 117360.

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • Stabilizing and strengthening the US physician-scientist faculty workforce in academic medicine: a proposed institutional framework

      Williams, C. S., Allen, M., Cooper-Byas, P., Hawley, J., Muglia, L. J., Abel, E. D., Bastarache, J. A., Calfee, C., Carethers, J. M., Cornfield, D. N., Eickelberg, O., Gallagher, E. J., Greka, A., Gruber, P. J., Hollenberg, A. N., Kong, H. H., Kazmierczak, B., Koretzky, G. A., Lachs, M. & Lenschow, D. J. & 8 others, Pitt, G., Rockey, D. C., Satlin, L. M., Sleckman, B. P., Stoltz, D. A., Vyas, J. M., Wang, T. J. & Rhee, K. Y., Apr 28 2026, In: JCI Insight. 11, 12, e205939.

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • IFNs: Maestros of the Immune System

      Fox, L. E. & Lenschow, D. J., Sep 1 2024, In: Journal of Immunology. 213, 5, p. 541-542 2 p.

      Research output: Contribution to journal › Review article › peer-review

    • Initiator cell death event induced by SARS-CoV-2 in the human airway epithelium

      Liang, K., Barnett, K. C., Hsu, M., Chou, W. C., Bais, S. S., Riebe, K., Xie, Y., Nguyen, T. T., Oguin, T. H., Vannella, K. M., Hewitt, S. M., Chertow, D. S., Blasi, M., Sempowski, G. D., Karlsson, A., Koller, B. H., Lenschow, D. J., Randell, S. H. & Ting, J. P. Y., 2024, In: Science immunology. 9, 97, eadn0178.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      39   Link opens in a new tab Scopus citations

    • En garde! The duel functions of MORC3

      Fox, L. E. & Lenschow, D. J., Jan 12 2022, In: Cell host & microbe. 30, 1, p. 8-9 2 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
    View all 71 Research outputs