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Personal profile

Research interests

My lab studies the genomics and epigenomics of AML, with an emphasis on how AML mutations alter the epigenome and gene expression. I am also interested in developing genomic methods for diagnosis and disease monitoring in AML patients.

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Research Output

Contribution of CTCF binding to transcriptional activity at the HOXA locus in NPM1-mutant AML cells

Ghasemi, R., Struthers, H., Wilson, E. R. & Spencer, D. H., Jan 1 2020, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Open Access
  • 1 Scopus citations

    Deletions in BCP-ALL result in a TAD more FLT3

    Spencer, D. H., Aug 20 2020, In : Blood. 136, 8, p. 919-920 2 p.

    Research output: Contribution to journalArticle

    Open Access

    Remethylation of Dnmt3a−/− hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing

    Ketkar, S., Verdoni, A. M., Smith, A. M., Bangert, C. V., Leight, E. R., Chen, D. Y., Brune, M. K., Helton, N. M., Hoock, M., George, D. R., Fronick, C., Fulton, R. S., Ramakrishnan, S. M., Chang, G. S., Petti, A. A., Spencer, D. H., Miller, C. A. & Ley, T. J., Feb 11 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 6, p. 3123-3134 12 p.

    Research output: Contribution to journalArticle

    Open Access
  • Immunological ignorance is an enabling feature of the oligo-clonal T cell response to melanoma neoantigens

    Linette, G. P., Becker-Hapak, M., Skidmore, Z. L., Baroja, M. L., Xu, C., Hundal, J., Spencer, D. H., Fu, W., Cummins, C., Robnett, M., Kaabinejadian, S., Hildebrand, W. H., Magrini, V., Demeter, R., Krupnick, A. S., Griffith, O. L., Griffith, M., Mardis, E. R. & Carreno, B. M., Nov 19 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 47, p. 23662-23670 9 p.

    Research output: Contribution to journalArticle

  • 5 Scopus citations

    Inflammatory cytokines promote clonal hematopoiesis with specific mutations in ulcerative colitis patients

    Zhang, C. R. C., Nix, D., Gregory, M., Ciorba, M. A., Ostrander, E. L., Newberry, R. D., Spencer, D. H. & Challen, G. A., Dec 2019, In : Experimental Hematology. 80, p. 36-41.e3

    Research output: Contribution to journalArticle

  • 8 Scopus citations