Research output per year
Research output per year
Personal profile
Research interests
Our lab focuses on the pathogenesis and host response to Klebsiella pneumoniae, an increasingly resistant and versatile organism. One of only three threats deemed "urgent" by the CDC, resistant Klebsiella infections kill half of people afflicted and are only increasing in prevalence. Utilizing mouse models of pneumonia, bacteremia and urinary tract infection (UTI), we are dissecting just how this bacterium causes infection in the host and how the host responds. We are particularly interested in adaptive responses to Klebsiella pneumoniae including the development of broad and effective vaccines.
Clinical interests
Pediatric infectious diseases, resistant bacterial infections
Mentoring
Excited to host trainees in my Klebsiella pathogenesis lab. Please contact me directly to hear more about potential projects.
Available to Mentor:
- Undergraduate Students
- PhD/MSTP Students
- Postdocs
- Residents and Fellows
Fingerprint
Dive into the research topics where David Rosen is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Lung infection with classical Klebsiella pneumoniae strains establishes robust macrophage-dependent protection against heterologous reinfection
Mackel, J. J., Mick, C. L. G., Guo, E. & Rosen, D. A., 2024, (Accepted/In press) In: Microbes and Infection. 105369.Research output: Contribution to journal › Article › peer-review
Open Access -
Vaccine value profile for Klebsiella pneumoniae
Dangor, Z., Benson, N., Berkley, J. A., Bielicki, J., Bijsma, M. W., Broad, J., Buurman, E. T., Cross, A., Duffy, E. M., Holt, K. E., Iroh Tam, P. Y., Jit, M., Karampatsas, K., Katwere, M., Kwatra, G., Laxminarayan, R., Le Doare, K., Mboizi, R., Micoli, F. & Moore, C. E. & 12 others, , Jul 25 2024, In: Vaccine. 42, 19, p. S125-S141Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Airway multidrug-resistant organisms in a population of tracheostomy and chronic ventilator-dependent children at a tertiary care pediatric hospital
Havens, T. N., Rosen, D. A. & Rivera-Spoljaric, K., Jan 2023, In: Pediatric Pulmonology. 58, 1, p. 26-34 9 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Capsular polysaccharide inhibits vaccine-induced O-antigen antibody binding and function across both classical and hypervirulent K2:O1 strains of Klebsiella pneumoniae
Wantuch, P. L., Knoot, C. J., Robinson, L. S., Vinogradov, E., Scott, N. E., Harding, C. M. & Rosen, D. A., May 2023, In: PLoS pathogens. 19, 5, e1011367.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Discovery and characterization of a new class of O-linking oligosaccharyltransferases from the Moraxellaceae family
Knoot, C. J., Wantuch, P. L., Robinson, L. S., Rosen, D. A., Scott, N. E. & Harding, C. M., Jan 1 2023, In: Glycobiology. 33, 1, p. 57-74 18 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations