Research output per year
Research output per year
Personal profile
Research interests
Our lab focuses on the pathogenesis and host response to Klebsiella pneumoniae, an increasingly resistant and versatile organism. One of only three threats deemed "urgent" by the CDC, resistant Klebsiella infections kill half of people afflicted and are only increasing in prevalence. Utilizing mouse models of pneumonia, bacteremia and urinary tract infection (UTI), we are dissecting just how this bacterium causes infection in the host and how the host responds. We are particularly interested in adaptive responses to Klebsiella pneumoniae including the development of broad and effective vaccines.
Clinical interests
Pediatric infectious diseases, resistant bacterial infections
Mentoring
Excited to host trainees in my Klebsiella pathogenesis lab. Please contact me directly to hear more about potential projects.
Available to Mentor:
- Undergraduate Students
- PhD/MSTP Students
- Postdocs
- Residents and Fellows
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Collaborations and top research areas from the last five years
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Airway multidrug-resistant organisms in a population of tracheostomy and chronic ventilator-dependent children at a tertiary care pediatric hospital
Havens, T. N., Rosen, D. A. & Rivera-Spoljaric, K., Jan 2023, In: Pediatric Pulmonology. 58, 1, p. 26-34 9 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Capsular polysaccharide inhibits vaccine-induced O-antigen antibody binding and function across both classical and hypervirulent K2:O1 strains of Klebsiella pneumoniae
Wantuch, P. L., Knoot, C. J., Robinson, L. S., Vinogradov, E., Scott, N. E., Harding, C. M. & Rosen, D. A., May 2023, In: PLoS pathogens. 19, 5, e1011367.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Discovery and characterization of a new class of O-linking oligosaccharyltransferases from the Moraxellaceae family
Knoot, C. J., Wantuch, P. L., Robinson, L. S., Rosen, D. A., Scott, N. E. & Harding, C. M., Jan 8 2023, In: Glycobiology. 33, 1, p. 57-74 18 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Listserv to Support Community Pediatric Clinicians During the COVID-19 Pandemic
Smith, G. D., Thomas, S. L., Orscheln, R. C., Reyes, S. M., Reyes, S. A., Rosen, D. A., Terrill, C. M., Dodd, S., Plax, K. & Newland, J. G., Apr 1 2023, In: Journal of the Pediatric Infectious Diseases Society. 12, 4, p. 254-255 2 p.Research output: Contribution to journal › Letter › peer-review
Open Access -
Replicative Acinetobacter baumannii strains interfere with phagosomal maturation by modulating the vacuolar pH
Distel, J. S., Di Venanzio, G., Mackel, J. J., Rosen, D. A. & Feldman, M. F., Jun 2023, In: PLoS pathogens. 19, 6, e1011173.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations