Research output per year
Research output per year
Personal profile
Research interests
Our lab focuses on the pathogenesis and host response to Klebsiella pneumoniae, an increasingly resistant and versatile organism. One of only three threats deemed "urgent" by the CDC, resistant Klebsiella infections kill half of people afflicted and are only increasing in prevalence. Utilizing mouse models of pneumonia, bacteremia and urinary tract infection (UTI), we are dissecting just how this bacterium causes infection in the host and how the host responds. We are particularly interested in adaptive responses to Klebsiella pneumoniae including the development of broad and effective vaccines.
Clinical interests
Pediatric infectious diseases, resistant bacterial infections
Mentoring
Excited to host trainees in my Klebsiella pathogenesis lab. Please contact me directly to hear more about potential projects.
Available to Mentor:
- Undergraduate Students
- PhD/MSTP Students
- Postdocs
- Residents and Fellows
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Collaborations and top research areas from the last five years
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Antibody responses in Klebsiella pneumoniae bloodstream infection: a prospective cohort study
Hwang, W., Wantuch, P. L., Bernshtein, B., Zhiteneva, J. A., Slater, D. M., Vater, K. H., Sridhar, S., Oliver, E., Roach, D. J., Rao, S. R., Turbett, S. E., Knoot, C. J., Harding, C. M., Amin, M. N., Cross, A. S., LaRocque, R. C., Rosen, D. A. & Harris, J. B., Apr 2025, In: The Lancet Microbe. 6, 4, 100988.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Klebsiella pneumoniae bioconjugate vaccine functional durability in mice
Wantuch, P. L., Knoot, C. J., Marino, E. C., Harding, C. M. & Rosen, D. A., Jan 1 2025, In: Vaccine. 43, 126536.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Heptavalent O-Antigen Bioconjugate Vaccine Exhibiting Differential Functional Antibody Responses Against Diverse Klebsiella pneumoniae Isolates
Wantuch, P. L., Knoot, C. J., Robinson, L. S., Vinogradov, E., Scott, N. E., Harding, C. M. & Rosen, D. A., Sep 15 2024, In: Journal of Infectious Diseases. 230, 3, p. 578-589 12 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Lung infection with classical Klebsiella pneumoniae strains establishes robust macrophage-dependent protection against heterologous reinfection
Mackel, J. J., Mick, C. L. G., Guo, E. & Rosen, D. A., Nov 1 2024, In: Microbes and Infection. 26, 8, 105369.Research output: Contribution to journal › Article › peer-review
Open Access -
Vaccine value profile for Klebsiella pneumoniae
Dangor, Z., Benson, N., Berkley, J. A., Bielicki, J., Bijsma, M. W., Broad, J., Buurman, E. T., Cross, A., Duffy, E. M., Holt, K. E., Iroh Tam, P. Y., Jit, M., Karampatsas, K., Katwere, M., Kwatra, G., Laxminarayan, R., Le Doare, K., Mboizi, R., Micoli, F. & Moore, C. E. & 12 others, , Jul 25 2024, In: Vaccine. 42, 19, p. S125-S141Research output: Contribution to journal › Article › peer-review
20 Scopus citations