• 1486 Citations
1982 …2020

Research output per year

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Personal profile

Research interests

The common theme of my research interests is the extraction of accurate quantitative information from measured biological and physical signals with the goal of advancing human health, safety, and welfare. My primary emphasis is on quantitative medical imaging, particularly single- and multiple-energy computed tomography (CT) and positron-emission tomography (PET). Accurate physical models of the underlying process and scanning system lead to accurate mathematical models, which in turn are used in the formulation of optimal algorithms from estimation theory for determining the measured quantity of interest. We are applying this methodology to more accurately characterize tissue, with the aim of improving radiation treatment plans.

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Research Output

  • 1486 Citations
  • 43 Article
  • 21 Conference contribution
  • 5 Conference article
  • 2 Paper

Accurate proton stopping power images reconstructed using joint statistical dual energy CT: Experimental verification and impact of fan-beam CT scatter

Medrano, M., Liu, R., Webb, T., Zhao, T., Williamson, J., Whiting, B., Politte, D. G., Porras-Chaverri, M. & O’Sullivan, J. A., 2020, Medical Imaging 2020: Physics of Medical Imaging. Chen, G-H. & Bosmans, H. (eds.). SPIE, 113121S. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 11312).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

  • Experimental implementation of a joint statistical image reconstruction method for proton stopping power mapping from dual-energy CT data

    Zhang, S., Han, D., Williamson, J. F., Zhao, T., Politte, D. G., Whiting, B. R. & O’Sullivan, J. A., Jan 2019, In : Medical physics. 46, 1, p. 273-285 13 p.

    Research output: Contribution to journalArticle

  • 5 Scopus citations

    Low-dose photon counting CT reconstruction bias reduction with multi-energy alternating minimization algorithm

    Lu, J., Zhang, S., Politte, D. G. & O'Sullivan, J. A., Jan 1 2019, 15th International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine. Matej, S. & Metzler, S. D. (eds.). SPIE, 110721Q. (Proceedings of SPIE - The International Society for Optical Engineering; vol. 11072).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  • Accelerating iterative image reconstruction via adaptive surrogate functions

    Mitra, A., Politte, D. G. & O'Sullivan, J. A., Jan 1 2018, In : IS and T International Symposium on Electronic Imaging Science and Technology. S2.

    Research output: Contribution to journalConference article

  • Highly accurate model for prediction of lung nodule malignancy with CT scans

    Causey, J. L., Zhang, J., Ma, S., Jiang, B., Qualls, J. A., Politte, D. G., Prior, F., Zhang, S. & Huang, X., Dec 1 2018, In : Scientific reports. 8, 1, 9286.

    Research output: Contribution to journalArticle

    Open Access
  • 46 Scopus citations