David Perlmutter

Balistreri, W. F., Grand, R., Hoofnagle, J. H., Suchy, F. J., Ryckman, F. C., Perlmutter, D. H. & Sokol, R. J., 1996, In: Hepatology. 23, 6, p. 1682-1692 11 p.

Research output: Contribution to journal › Article › peer-review

313 Scopus citations

Biliary atresia: Current concepts and research directions. Summary of a symposium

Balistreri, W. F., Grand, R., Hoofnagle, J. H., Suchy, F. J., Ryckman, F. C., Perlmutter, D. & Sokol, R. J., Jun 24 1996, In: Hepatology. 23, 6, p. 1682-1692 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Degradation of a mutant secretory protein, α ₁-antitrypsin Z, in the endoplasmic reticulum requires proteasome activity

Qu, D., Teckman, J. H., Omura, S. & Perlmutter, D. H., 1996, In: Journal of Biological Chemistry. 271, 37, p. 22791-22795 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

316 Scopus citations

Molecular pathogenesis of liver disease in α₁-antitrypsin deficiency

Teckman, J. H., Qu, D. & Perlmutter, D. H., 1996, In: Hepatology. 24, 6, p. 1504-1516 13 p.

Research output: Contribution to journal › Article › peer-review

110 Scopus citations

Regulation of sucrase-isomaltase gene expression in human intestinal epithelial cells by inflammatory cytokines

Ziambaras, T., Rubin, D. C. & Perlmutter, D. H., Jan 12 1996, In: Journal of Biological Chemistry. 271, 2, p. 1237-1242 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

54 Scopus citations

Site-directed mutagenesis within an ectoplasmic ATPase consensus sequence abrogates the cell aggregating properties of the rat liver canalicular bile acid transporter/ecto-ATPase/cell CAM 105 and carcinoembryonic antigen

Sippel, C. J., Shen, T. & Perlmutter, D. H., 1996, In: Journal of Biological Chemistry. 271, 51, p. 33095-33104 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

The endoplasmic reticulum degradation pathway for mutant secretory proteins α1-antitrypsin Z and S is distinct from that for an unassembled membrane protein

Teckman, J. H. & Perlmutter, D. H., 1996, In: Journal of Biological Chemistry. 271, 22, p. 13215-13220 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

89 Scopus citations

The serpin-enzyme complex receptor recognizes soluble, nontoxic amyloid- β peptide but not aggregated, cytotoxic amyloid-β peptide

Boland, K., Behrens, M., Choi, D., Manias, K. & Perlmutter, D. H., 1996, In: Journal of Biological Chemistry. 271, 30, p. 18032-18044 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

81 Scopus citations

1995

AVANCES EN LA PATOGENESIS Y TRATAMIENTO DE LAS HEPATOPATIAS METABOLICAS EN LA INFANCIA (PRIMERA PARTE)

Translated title of the contribution: The progress in pathogenesis and treatment of metabolic hepatopathies in infants (first part)Teckman, J. & Perlmutter, D. H., Dec 1 1995, In: Practica Pediatrica. 4, 11, p. 28-39 12 p.

Research output: Contribution to journal › Short survey › peer-review

Cellular expression of the C5a anaphylatoxin receptor (C5aR): Demonstration of C5aR on nonmyeloid cells of the liver and lung

Haviland, D. L., McCoy, R. L., Whitehead, W. T., Akama, H., Molmenti, E. P., Brown, A., Haviland, J. C., Parks, W. C., Perlmutter, D. H. & Wetsel, R. A., Feb 15 1995, In: Journal of Immunology. 154, 4, p. 1861-1869 9 p.

Research output: Contribution to journal › Article › peer-review

216 Scopus citations

Clinical manifestations of alpha₁-antitrypsin deficiency

Perlmutter, D. H., Jan 1 1995, In: Gastroenterology Clinics of North America. 24, 1, p. 27-43 17 p.

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

Conceptual advances in the pathogenesis and treatment of childhood metabolic liver disease

Teckman, J. & Perlmutter, D. H., Apr 1995, In: Gastroenterology. 108, 4, p. 1263-1279 17 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

25 Scopus citations

N-formylpeptide and complement C5a receptors are expressed in liver cells and mediate hepatic acute phase gene regulation

McCoy, R., Haviland, D. L., Molmenti, E. P., Ziambaras, T., Wetsel, R. A. & Perlmutter, D. H., Jul 1 1995, In: Journal of Experimental Medicine. 182, 1, p. 207-217 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

107 Scopus citations

Society for pediatric research presidential address 1995: Marrying our medicine to biology

Perlmutter, D. H., Dec 1995, In: Pediatric research. 38, 6, p. 830-834 5 p.

Research output: Contribution to journal › Comment/debate

Open Access

Specificity in recognition of amyloid-β peptide by the serpin-enzyme complex receptor in hepatoma cells and neuronal cells

Boland, K., Manias, K. & Perlmutter, D. H., Nov 24 1995, In: Journal of Biological Chemistry. 270, 47, p. 28022-28028 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Scopus citations

1994

A lag in intracellular degradation of mutant α₁-antitrypsin correlates with the liver disease phenotype in homozygous PiZZ α₁-antitrypsin deficiency

Wu, Y., Whitman, I., Molmenti, E., Moore, K., Hippenmeyer, P. & Perlmutter, D. H., Sep 13 1994, In: Proceedings of the National Academy of Sciences of the United States of America. 91, 19, p. 9014-9018 5 p.

Research output: Contribution to journal › Article › peer-review

239 Scopus citations

Bile acid efflux mediated by the rat liver canalicular bile acid transport/ecto-ATPase protein requires serine 503 phosphorylation and is regulated by tyrosine 488 phosphorylation

Sippel, C. J., Fallon, R. J. & Perlmutter, D. H., Jul 29 1994, In: Journal of Biological Chemistry. 269, 30, p. 19539-19545 7 p.

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Bile Acid Transport by the Rat Liver Canalicular Bile Acid Transport/Ecto-ATPase Protein Is Dependent on ATP but Not on Its Own Ecto-ATPase Activity

Sippel, C. J., McCollum, M. J. & Perlmutter, D. H., Jan 28 1994, In: Journal of Biological Chemistry. 269, 4, p. 2820-2826 7 p.

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Metabolic liver disease in childhood

Perlmutter, D. H., Jan 1 1994, In: Seminars in Gastrointestinal Disease. 5, 2, p. 54-64 11 p.

Research output: Contribution to journal › Review article › peer-review

The SEC receptor: A possible link between neonatal hepatitis in α1-antitrypsin deficiency and alzheimer's disease

Perlmutter, D. H., Sep 1994, In: Pediatric research. 36, 3, p. 271-277 7 p.

Research output: Contribution to journal › Comment/debate

Open Access

14 Scopus citations

1993

Cell-specific expression of α₁-antitrypsin in human intestinal epithelium

Molmenti, E. P., Perlmutter, D. H. & Rubin, D. C., 1993, In: Journal of Clinical Investigation. 92, 4, p. 2022-2034 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

117 Scopus citations

Cross-competition for binding of α₁-antitrypsin (α₁ AT)-elastase complexes to the serpin-enzyme complex receptor by other serpin-enzyme complexes and by proteolytically modified α₁ AT

Joslin, G., Wittwer, A., Adams, S., Tollefsen, D. M., August, A. & Perlmutter, D. H., Jan 25 1993, In: Journal of Biological Chemistry. 268, 3, p. 1886-1893 8 p.

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Evidence for an acute phase response in human intestinal epithelial cells

Molmenti, E. P., Ziambaras, T. & Perlmutter, D. H., Jul 5 1993, In: Journal of Biological Chemistry. 268, 19, p. 14116-14124 9 p.

Research output: Contribution to journal › Article › peer-review

222 Scopus citations

Liver disease associated with alpha 1-antitrypsin deficiency.

Perlmutter, D. H., 1993, In: Progress in liver diseases. 11, p. 139-165 27 p.

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

The rat liver ecto-ATPase is also a canalicular bile acid transport protein

Sippel, C. J., Suchy, F. J., Ananthanarayanan, M. & Perlmutter, D. H., Jan 25 1993, In: Journal of Biological Chemistry. 268, 3, p. 2083-2091 9 p.

Research output: Contribution to journal › Article › peer-review

117 Scopus citations

1992

Constitutive and modulated expression of the human α₁ antitrypsin gene. Different transcriptional initiation sites used in three different cell types

Hafeez, W., Ciliberto, G. & Perlmutter, D. H., 1992, In: Journal of Clinical Investigation. 89, 4, p. 1214-1222 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

64 Scopus citations

Inborn errors of metabolism

Molleston, J. P. & Perlmutter, D. H., Jan 1 1992, In: Current opinion in pediatrics. 4, 5, p. 798-804 7 p.

Research output: Contribution to journal › Review article › peer-review

The serpin-enzyme complex (SEC) receptor mediates the neutrophil chemotactic effect of α-₁ antitrypsin-elastase complexes and amyloid-β peptide

Joslin, G., Griffin, G. L., August, A. M., Adams, S., Fallen, R. J., Senior, R. M. & Perlmutter, D. H., 1992, In: Journal of Clinical Investigation. 90, 3, p. 1150-1154 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

73 Scopus citations

1991

Amyloid-β peptide, substance P, and bombesin bind to the serpin-enzyme complex receptor

Joslin, G., Krause, J. E., Hershey, A. D., Adams, S. P., Fallon, R. J. & Perlmutter, D. H., 1991, In: Journal of Biological Chemistry. 266, 32, p. 21897-21902 6 p.

Research output: Contribution to journal › Article › peer-review

106 Scopus citations

Effect of pseudomonas elastase on human mononuclear phagocyte α₁-antitrypsin expression

Barbey-Morel, C. & Perlmutter, D. H., Feb 1991, In: Pediatric research. 29, 2, p. 133-140 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Expression of stress proteins in human mononuclear phagocytes

Joslin, G., Hafeez, W. & Perlmutter, D. H., Sep 1 1991, In: Journal of Immunology. 147, 5, p. 1614-1620 7 p.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

The cellular basis for liver injury in α₁‐antitrypsin deficiency

Perlmutter, D. H., Jan 1991, In: Hepatology. 13, 1, p. 172-185 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

66 Scopus citations

The SEC receptor recognizes a pentapeptide neodomain of α₁-antitrypsin-protease complexes

Joslin, G., Fallon, R. J., Bullock, J., Adams, S. P. & Perlmutter, D. H., 1991, In: Journal of Biological Chemistry. 266, 17, p. 11282-11288 7 p.

Research output: Contribution to journal › Article › peer-review

105 Scopus citations

1990

Conference summary: Mechanisms and management of pediatric hepatobiliary disease

Balistreri, W. F., Boyer, J. L., Carpenter, G., Desmet, V. J., Fausto, N., Goldfischer, S. L., Horwitz, M. S., Hutton, J. J., Javitt, N. B., Lazarow, P. B., Lilly, J. R., McDonagh, A. F., Moser, H. W., Perlmutter, D. H., Schwartz, A. L., Shafritz, D. A. & Zuckerman, A. J., Jan 1990, In: Journal of pediatric gastroenterology and nutrition. 10, 1, p. 138-147 10 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Counterregulatory effects of interferon-γ and endotoxin on expression of the human C4 genes

Kulics, J., Colten, H. R. & Perlmutter, D. H., Mar 1990, In: Journal of Clinical Investigation. 85, 3, p. 943-949 7 p.

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Endocytosis and degradation of α₁-Antitrypsin-protease complexes is mediated by the Serpin-Enzyme Complex (SEC) receptor

Perlmutter, D. H., Joslin, G., Nelson, P., Schasteen, C., Adams, S. P. & Fallon, R. J., Oct 5 1990, In: Journal of Biological Chemistry. 265, 28, p. 16713-16716 4 p.

Research output: Contribution to journal › Article › peer-review

115 Scopus citations

Identification of a serpin-enzyme complex receptor on human hepatoma cells and human monocytes

Perlmutter, D. H., Glover, G. I., Rivetna, M., Schasteen, C. S. & Fallon, R. J., 1990, In: Proceedings of the National Academy of Sciences of the United States of America. 87, 10, p. 3753-3757 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

175 Scopus citations

1989

A cytokine-selective defect in interleukin-1β-mediated acute phase gene expression in a subclone of the human hepatoma cell line (HepG2)

Perlmutter, D. H., Colten, H. R., Adams, S. P., May, L. T., Sehgal, P. B. & Fallon, R. J., 1989, In: Journal of Biological Chemistry. 264, 13, p. 7669-7674 6 p.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

IFNβ2/IL‐6 Is One of Several Cytokines That Modulate Acute Phase Gene Expression in Human Hepatocytes and Human Macrophages

PERLMUTTER, D. H., Jun 1989, In: Annals of the New York Academy of Sciences. 557, 1, p. 332-342 11 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Interferon β2/interleukin 6 modulates synthesis of α₁-antitrypsin in human mononuclear phagocytes and in human hepatoma cells

Perlmutter, D. H., May, L. T. & Sehgal, P. B., 1989, In: Journal of Clinical Investigation. 84, 1, p. 138-144 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

114 Scopus citations

Intestinal alkaline phosphatase is secreted bidirectionally from villous enterocytes

Sussman, N. L., Eliakim, R., Rubin, D., Perlmutter, D. H., DeSchryver-Kecskemeti, K. & Alpers, D. H., 1989, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 257, 1, p. 20/1

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Molecular basis of complement deficiencies

Perlmutter, D. H. & Colten, H. R., Jan 1 1989, In: Immunodeficiency Reviews. 1, 2, p. 105-133 29 p.

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

David Perlmutter

Research output

Search results