David Perlmutter

Executive Vice Chancellor for Medical Affairs, Dean of the School of Medicine, Professor of Pediatrics, Spencer T and Ann W Olin Distinguished Professor in the School of Medicine, George and Carol Bauer Dean of the School of Medicine

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    PhD/MSTP Students

    • 19333
    1983 …2022

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    Research interests

    Dr. Perlmutter is internationally recognized for his research on the pathobiology of α1-antitrypsin deficiency, a rare disease in which a misfolded protein causes chronic liver failure and hepatocellular carcinoma. His work has led to advances in understanding the basic mechanisms of liver fibrosis and carcinoma and novel therapeutic strategies. Together with collaborators he has discovered a pipeline of drugs that can eliminate misfolded proteins and reverse the liver disease in model organisms. One of these drugs has advanced to phase II/III clinical trials. The class of drugs may also be utilized for other diseases caused by misfolded proteins, including Alzheimer’s disease and other age-dependent degenerative diseases.

    Available to Mentor:

    • PhD/MSTP Students


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