David Perlmutter

Executive Vice Chancellor for Medical Affairs, Dean of the School of Medicine, Professor of Pediatrics, Spencer T and Ann W Olin Distinguished Professor in the School of Medicine, George and Carol Bauer Dean of the School of Medicine

  • 16439 Citations
1983 …2020

Research output per year

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Personal profile

Research interests

Dr. Perlmutter is internationally recognized for his research on the pathobiology of α1-antitrypsin deficiency, a rare disease in which a misfolded protein causes chronic liver failure and hepatocellular carcinoma. His work has led to advances in understanding the basic mechanisms of liver fibrosis and carcinoma and novel therapeutic strategies. Together with collaborators he has discovered a pipeline of drugs that can eliminate misfolded proteins and reverse the liver disease in model organisms. One of these drugs has advanced to phase II/III clinical trials. The class of drugs may also be utilized for other diseases caused by misfolded proteins, including Alzheimer’s disease and other age-dependent degenerative diseases.

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Research Output

Mechanisms of action of autophagy modulators dissected by quantitative systems pharmacology analysis

Shi, Q., Pei, F., Silverman, G. A., Pak, S. C., Perlmutter, D. H., Liu, B. & Bahar, I., Apr 1 2020, In : International journal of molecular sciences. 21, 8, 2855.

Research output: Contribution to journalArticle

Open Access
  • An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z

    Wang, Y., Cobanoglu, M. C., Li, J., Hidvegi, T., Hale, P., Ewing, M., Chu, A. S., Gong, Z., Muzumdar, R., Pak, S. C., Silverman, G. A., Bahar, I. & Perlmutter, D. H., Jan 2019, In : PloS one. 14, 1, e0209748.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations

    Identification of Polycystic Kidney Disease 1 Like 1 Gene Variants in Children With Biliary Atresia Splenic Malformation Syndrome

    for the Childhood Liver Disease Research Network (ChiLDReN), Jan 1 2019, In : Hepatology. 70, 3, p. 899-910 12 p.

    Research output: Contribution to journalArticle

  • 11 Scopus citations

    NFκB mitigates the pathological effects of misfolded α1-antitrypsin by activating autophagy and an integrated program of proteostasis mechanisms

    Mukherjee, A., Hidvegi, T., Araya, P., Ewing, M., Stolz, D. B. & Perlmutter, D. H., Mar 1 2019, In : Cell Death and Differentiation. 26, 3, p. 455-469 15 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    Quantitative assessment of cell fate decision between autophagy and apoptosis

    Liu, B., Oltvai, Z. N., Baylr, H., Silverman, G. A., Pak, S. C., Perlmutter, D. H. & Bahar, I., Dec 1 2017, In : Scientific reports. 7, 1, 17605.

    Research output: Contribution to journalArticle

    Open Access
  • 13 Scopus citations