Research output per year
Research output per year
Personal profile
Research interests
Dr. Perlmutter is internationally recognized for his research on the pathobiology of α1-antitrypsin deficiency, a rare disease in which a misfolded protein causes chronic liver failure and hepatocellular carcinoma. His work has led to advances in understanding the basic mechanisms of liver fibrosis and carcinoma and novel therapeutic strategies. Together with collaborators he has discovered a pipeline of drugs that can eliminate misfolded proteins and reverse the liver disease in model organisms. One of these drugs has advanced to phase II/III clinical trials. The class of drugs may also be utilized for other diseases caused by misfolded proteins, including Alzheimer’s disease and other age-dependent degenerative diseases.
Available to Mentor:
- PhD/MSTP Students
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Age-related Huntington’s disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy
Oh, Y. M., Lee, S. W., Kim, W. K., Chen, S., Church, V. A., Cates, K., Li, T., Zhang, B., Dolle, R. E., Dahiya, S., Pak, S. C., Silverman, G. A., Perlmutter, D. H. & Yoo, A. S., Nov 2022, In: Nature neuroscience. 25, 11, p. 1420-1433 14 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Investing in the Advancement of Science
Perlmutter, D. H., Sep 1 2022, In: Missouri Medicine. 119, 5, p. 429-431 3 p.Research output: Contribution to journal › Article › peer-review
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Regulation of PGC1α Downstream of the Insulin Signaling Pathway Plays a Role in the Hepatic Proteotoxicity of Mutant α1-Antitrypsin Deficiency Variant Z
Rudnick, D. A., Huang, J., Hidvegi, T., Chu, A. S., Hale, P., Munanairi, A., Dietzen, D. J., Cliften, P. F., Tycksen, E., Lutkewitte, A. J., Finck, B. N., Pak, S. C., Silverman, G. A. & Perlmutter, D. H., Jul 2022, In: Gastroenterology. 163, 1, p. 270-284 15 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Mechanisms of action of autophagy modulators dissected by quantitative systems pharmacology analysis
Shi, Q., Pei, F., Silverman, G. A., Pak, S. C., Perlmutter, D. H., Liu, B. & Bahar, I., Apr 1 2020, In: International journal of molecular sciences. 21, 8, 2855.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
αl-antitrypsin deficiency
Rudnick, D. A. & Perlmutter, D. H., Jan 24 2020, The Liver: Biology and Pathobiology. wiley, p. 645-658 14 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review