David Perlmutter

Executive Vice Chancellor for Medical Affairs, Dean of the School of Medicine, Professor of Pediatrics, Spencer T and Ann W Olin Distinguished Professor in the School of Medicine, George and Carol Bauer Dean of the School of Medicine

    • Source: Scopus
    1983 …2020

    Research output per year

    If you made any changes in Pure these will be visible here soon.

    Personal profile

    Research interests

    Dr. Perlmutter is internationally recognized for his research on the pathobiology of α1-antitrypsin deficiency, a rare disease in which a misfolded protein causes chronic liver failure and hepatocellular carcinoma. His work has led to advances in understanding the basic mechanisms of liver fibrosis and carcinoma and novel therapeutic strategies. Together with collaborators he has discovered a pipeline of drugs that can eliminate misfolded proteins and reverse the liver disease in model organisms. One of these drugs has advanced to phase II/III clinical trials. The class of drugs may also be utilized for other diseases caused by misfolded proteins, including Alzheimer’s disease and other age-dependent degenerative diseases.

    Fingerprint

    Dive into the research topics where David Perlmutter is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
    • 4 Similar Profiles

    Network

    Recent external collaboration on country level. Dive into details by clicking on the dots.
    If you made any changes in Pure these will be visible here soon.