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Research interests

Fibroblast growth factors (FGFs) are essential molecules for mammalian development. Members of the FGF family regulate cell proliferation, migration and differentiation. Engineered mutations in the genes encoding several FGFs and FGF receptors (FGFRs) result in developmental defects and/or embryonic lethality. Additionally, gain of function point mutations in the genes encoding FGFRs 1, 2 and 3 result in hereditary craniofacial and skeletal dysplasias in humans. We have recently discovered that a subfamily of FGFs (FHFs) acts intracellularly in neurons and is important for neuronal signal transduction. Disruption of the intracellular signaling molecule, FGF14/FHF4 results in an anatomically normal mouse with severe neurobehavioral phenotypes including ataxia and paroxismal dystonia. We are interested in the mechanism of axonal trafficking of the FGF14/FHF4 protein in the cerebellum and striatum, and how FGF14/FHF4 regulates neuronal signaling in these parts of the brain. We are also studying the more classical FGFs and FGF receptors in mouse embryogenesis. Using knockout and conditional knockout technology we have constructed FGF and FGF receptor mutants with defects in skeletal, lung, and CNS development. These mutant mice are being studied as developmental model systems for branching morphogenesis, and skeletal and neuroepithelial patterning and growth. These mice are also being used as material for microarray profiling studies to identify interacting gene families.

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Research Output

Analysis of FGF20-regulated genes in organ of Corti progenitors by translating ribosome affinity purification

Yang, L. M., Stout, L., Rauchman, M. & Ornitz, D. M., 2020, (Accepted/In press) In : Developmental Dynamics.

Research output: Contribution to journalArticle

  • 1 Scopus citations
  • 1 Scopus citations

    FGFR2 Is Required for AEC2 Homeostasis and Survival after Bleomycin-induced Lung Injury

    Dorry, S. J., Ansbro, B. O., Ornitz, D. M., Mutlu, G. M. & Guzy, R. D., May 1 2020, In : American Journal of Respiratory Cell and Molecular Biology. 62, 5, p. 608-621 14 p.

    Research output: Contribution to journalArticle

  • 4 Scopus citations

    Geminin is required for Hox gene regulation to pattern the developing limb

    Lewis, E. M. A., Sankar, S., Tong, C., Patterson, E. S., Waller, L. E., Gontarz, P., Zhang, B., Ornitz, D. M. & Kroll, K. L., Jan 1 2020, (Accepted/In press) In : Developmental Biology.

    Research output: Contribution to journalArticle

  • Identification of a FGF18-expressing alveolar myofibroblast that is developmentally cleared during alveologenesis

    Hagan, A. S., Zhang, B. & Ornitz, D. M., Jan 1 2020, In : Development (Cambridge). 147, 2, dev181032.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations