The Ornitz laboratory studies the in vivo functions of Fibroblast Growth Factors (FGFs), their interactions with other signaling pathways, and their role in development, tissue homeostasis, regeneration, and injury response. We use in vivo mouse models, organ culture, and transcriptomics, and we apply our knowledge of developmental mechanisms to understand how growth factors regulate tissue homeostasis, and how reactivation of developmental programs functions in tissue homeostasis, regeneration, and injury response. The lab currently is working on three organ systems.

Respiratory system: We are investigating how FGF signaling pathways regulate alveologenesis, the final stage of lung development. These studies are aimed towards improving the outcomes of premature birth and preventing or treating bronchopulmonary dysplasia. We are investigating mechanisms by which endothelial and vascular smooth muscle FGF signaling is protective in hypoxia-induced pulmonary hypertension.

Cardiovascular system: We have developed a mouse model for heart failure with preserved ejection fraction (HFpEF) and we are investigating how FGF receptor signaling in myocytes, fibroblasts, vascular smooth muscle, and endothelial cells affects disease progression. We are using transcriptomic approaches to identify stage- and cell-specific changes in gene expression during HFpEF progression.

Skeletal system: We are studying an FGF-regulated signaling center adjacent to the growth plate that controls longitudinal bone growth. We are investigating mechanisms by which FGF signaling in osteoblasts regulates bone homeostasis, osteoblast anabolic activity, and survival of newly formed osteocytes. 

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