• 2209 Citations

Research output per year

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Personal profile

Research interests

The lab primarily studies the interactions of pathogenic Gram-negative bacteria with their hosts. In particular, we utilize tissue culture models and mouse models to investigate the modulation of host immune responses by pathogens, and to determine the mechanisms by which these bacteria present specific virulence factors on their surfaces. Currently, we are studying the molecular mechanisms by which conserved periplasmic chaperones, such as SurA and Skp, contribute to the assembly and presentation of surface virulence factors by Gram-negative pathogens. In addition, we are using cultured bladder epithelial cells and the murine model of cystitis to investigate the ability of uropathogenic E. coli to downregulate host inflammatory cytokine production. Our goal is to discover novel targets for interventions that will prevent and treat Gram-negative infections of the urinary tract, gastrointestinal tract, and central nervous system.

Areas of Clinical Interest

Pediatric infectious diseases, urinary tract infections, diagnostic medicine  

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Research Output

Androgen-Influenced Polarization of Activin A-Producing Macrophages Accompanies Post-pyelonephritic Renal Scarring

Hreha, T. N., Collins, C. A., Daugherty, A. L., Griffith, J. M., Hruska, K. A. & Hunstad, D. A., Jul 28 2020, In : Frontiers in immunology. 11, 1641.

Research output: Contribution to journalArticle

Open Access
  • Environmental Methicillin-resistant Staphylococcus aureus Contamination, Persistent Colonization, and Subsequent Skin and Soft Tissue Infection

    Hogan, P. G., Mork, R. L., Thompson, R. M., Muenks, C. E., Boyle, M. G., Sullivan, M. L., Morelli, J. J., Williams, C. V., Sanchez, N., Hunstad, D. A., Wardenburg, J. B., Gehlert, S. J., Burnham, C. A. D., Rzhetsky, A. & Fritz, S. A., Jun 2020, In : JAMA Pediatrics. 174, 6, p. 552-562 11 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Incidence and treatment of hemophagocytic lymphohistiocytosis in hospitalized children with Ehrlichia infection

    Cabler, S. S., Hogan, P. G., Fritz, S. A., Bednarski, J. & Hunstad, D., 2020, (Accepted/In press) In : Pediatric Blood and Cancer.

    Research output: Contribution to journalArticle

  • Perspective commentary from the Society for Pediatric Research: supporting early-stage pediatric physician–scientist success

    Hurley, E., Peeples, E. S., Bates, C. M., Hunstad, D. A. & Barkin, S. L., Apr 1 2020, In : Pediatric research. 87, 5, p. 834-838 5 p.

    Research output: Contribution to journalArticle

    Sex effects in pyelonephritis

    Albracht, C. D., Hreha, T. N. & Hunstad, D. A., Jan 1 2020, (Accepted/In press) In : Pediatric Nephrology.

    Research output: Contribution to journalReview article

  • 1 Scopus citations