Research output per year
Research output per year
- 500 - 550 out of 575 results
Search results
-
2002
Plaque-associated disruption of CSF and plasma amyloid-β (Aβ) equilibrium in a mouse model of Alzheimer's disease
DeMattos, R. B., Bales, K. R., Parsadanian, M., O'Dell, M. A., Foss, E. M., Paul, S. M. & Holtzman, D. M., 2002, In: Journal of Neurochemistry. 81, 2, p. 229-236 8 p.Research output: Contribution to journal › Article › peer-review
237 Scopus citations -
Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury.
Han, B. H., Xu, D., Choi, J., Han, Y., Xanthoudakis, S., Roy, S., Tam, J., Vaillancourt, J., Colucci, J., Siman, R., Giroux, A., Robertson, G. S., Zamboni, R., Nicholson, D. W. & Holtzman, D. M., Aug 16 2002, In: The Journal of biological chemistry. 277, 33, p. 30128-30136 9 p.Research output: Contribution to journal › Article › peer-review
Open Access172 Scopus citations -
Selective vulnerability of late oligodendrocyte progenitors to hypoxia-ischemia
Back, S. A., Han, B. H., Luo, N. L., Chricton, C. A., Xanthoudakis, S., Tam, J., Arvin, K. L. & Holtzman, D. M., Jan 15 2002, In: Journal of Neuroscience. 22, 2, p. 455-463 9 p.Research output: Contribution to journal › Article › peer-review
Open Access728 Scopus citations -
Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: Potential role in disease pathogenesis
Han, X., Holtzman, D. M., McKeel, D. W., Kelley, J. & Morris, J. C., Aug 2002, In: Journal of Neurochemistry. 82, 4, p. 809-818 10 p.Research output: Contribution to journal › Article › peer-review
518 Scopus citations -
2001
Amyloid β40/42 clearance across the blood-brain barrier following intra-ventricular injections in wild-type, apoE knock-out and human apoE3 or E4 expressing transgenic mice
Ji, Y., Permanne, B., Sigurdsson, E. M., Holtzman, D. M. & Wisniewski, T., 2001, In: Journal of Alzheimer's Disease. 3, 1, p. 23-30 8 p.Research output: Contribution to journal › Article › peer-review
78 Scopus citations -
BAX contributes to apoptotic-like death following neonatal hypoxia-ischemia: Evidence for distinct apoptosis pathways
Gibson, M. E., Byung, H. H., Choi, J., Knudson, C. M., Korsmeyer, S. J., Parsadanian, M. & Holtzman, D. M., 2001, In: Molecular Medicine. 7, 9, p. 644-655 12 p.Research output: Contribution to journal › Article › peer-review
Open Access115 Scopus citations -
Behavioral phenotyping of GFAP-ApoE3 and -ApoE4 transgenic mice: ApoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology
Hartman, R. E., Wozniak, D. F., Nardi, A., Olney, J. W., Sartorius, L. & Holtzman, D. M., 2001, In: Experimental Neurology. 170, 2, p. 326-344 19 p.Research output: Contribution to journal › Article › peer-review
140 Scopus citations -
Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia
Han, B. H., DeMattos, R. B., Dugan, L. L., Kim-Han, J. S., Brendza, R. P., Fryer, J. D., Kierson, M., Cirrito, J., Quick, K., Harmony, J. A. K., Aronow, B. J. & Holtzman, D. M., 2001, In: Nature medicine. 7, 3, p. 338-343 6 p.Research output: Contribution to journal › Article › peer-review
184 Scopus citations -
Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease
DeMattos, R. B., Bales, K. R., Cummins, D. J., Dodart, J. C., Paul, S. M. & Holtzman, D. M., Jul 17 2001, In: Proceedings of the National Academy of Sciences of the United States of America. 98, 15, p. 8850-8855 6 p.Research output: Contribution to journal › Article › peer-review
Open Access1233 Scopus citations -
Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: Molecular characterization using electrospray ionization mass spectrometry
Han, X., Holtzman, D. M. & McKeel, D. W., 2001, In: Journal of Neurochemistry. 77, 4, p. 1168-1180 13 p.Research output: Contribution to journal › Article › peer-review
441 Scopus citations -
Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice
DeMattos, R. B., Brendza, R. P., Heuser, J. E., Kierson, M., Cirrito, J. R., Fryer, J., Sullivan, P. M., Fagan, A. M., Han, X. & Holtzman, D. M., 2001, In: Neurochemistry International. 39, 5-6, p. 415-425 11 p.Research output: Contribution to journal › Article › peer-review
141 Scopus citations -
Role of apoE/Aβ interactions in the pathogenesis of Alzheimer's disease and cerebral amyloid angiopathy
Holtzman, D. M., 2001, In: Journal of Molecular Neuroscience. 17, 2, p. 147-155 9 p.Research output: Contribution to journal › Article › peer-review
128 Scopus citations -
Role of nerve growth factor in experimental autoimmune encephalomyelitis
Arredondo, L. C. R., Deng, C., Ratts, R. B., Lovett-Racke, A. E., Holtzman, D. M. & Racke, M. K., 2001, In: European Journal of Immunology. 31, 2, p. 625-633 9 p.Research output: Contribution to journal › Article › peer-review
Open Access58 Scopus citations -
2000
Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model
Holtzman, D. M., Fagan, A. M., Mackey, B., Tenkova, T., Sartorius, L., Paul, S. M., Bales, K., Ashe, K. H., Irizarry, M. C. & Hyman, B. T., 2000, In: Annals of neurology. 47, 6, p. 739-747 9 p.Research output: Contribution to journal › Article › peer-review
281 Scopus citations -
Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease
Holtzman, D. M., Bales, K. R., Tenkova, T., Fagan, A. M., Parsadanian, M., Sartorius, L. J., Mackey, B., Olney, J., McKeel, D., Wozniak, D. & Paul, S. M., Mar 14 2000, In: Proceedings of the National Academy of Sciences of the United States of America. 97, 6, p. 2892-2897 6 p.Research output: Contribution to journal › Article › peer-review
Open Access773 Scopus citations -
BDNF blocks caspase-3 activation in neonatal hypoxia-ischemia
Hee Han, B., D'Costa, A., Back, S. A., Parsadanian, M., Patel, S., Shah, A. R., Gidday, J. M., Srinivasan, A., Deshmukh, M. & Holtzman, D. M., Feb 2000, In: Neurobiology of Disease. 7, 1, p. 38-53 16 p.Research output: Contribution to journal › Article › peer-review
267 Scopus citations -
BDNF protects against spatial memory deficits following neonatal hypoxia-ischemia
Almli, C. R., Levy, T. J., Han, B. H., Shah, A. R., Gidday, J. M. & Holtzman, D. M., 2000, In: Experimental Neurology. 166, 1, p. 99-114 16 p.Research output: Contribution to journal › Article › peer-review
178 Scopus citations -
BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway
Han, B. H. & Holtzman, D. M., Aug 1 2000, In: Journal of Neuroscience. 20, 15, p. 5775-5781 7 p.Research output: Contribution to journal › Article › peer-review
Open Access494 Scopus citations -
Clearance of Alzheimer's amyloid-β1-40 peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier
Shibata, M., Yamada, S., Ram Kumar, S., Calero, M., Bading, J., Frangione, B., Holtzman, D. M., Miller, C. A., Strickland, D. K., Ghiso, J. & Zlokovic, B. V., 2000, In: Journal of Clinical Investigation. 106, 12, p. 1489-1499 11 p.Research output: Contribution to journal › Article › peer-review
Open Access1227 Scopus citations -
Differences in the Aβ40/Aβ42 ratio associated with cerebrospinal fluid lipoproteins as a function of apolipoprotein E genotype
Fagan, A. M., Younkin, L. H., Morris, J. C., Fryer, J. D., Cole, T. G., Younkin, S. G. & Holtzman, D. M., 2000, In: Annals of neurology. 48, 2, p. 201-210 10 p.Research output: Contribution to journal › Article › peer-review
Open Access121 Scopus citations -
Impaired synaptic plasticity and cAMP response element-binding protein activation in Ca2+/calmodulin-dependent protein kinase type IV/Gr-Deficient mice
Ho, N., Liauw, J. A., Blaeser, F., Wei, F., Hanissian, S., Muglia, L. M., Wozniak, D. F., Nardi, A., Arvin, K. L., Holtzman, D. M., Linden, D. J., Zhuo, M., Muglia, L. J. & Chatila, T. A., Sep 1 2000, In: Journal of Neuroscience. 20, 17, p. 6459-6472 14 p.Research output: Contribution to journal › Article › peer-review
Open Access240 Scopus citations -
Lipoproteins in the central nervous system
Ladu, M. J., Reardon, C., Van Eldik, L., Fagan, A. M., Bu, G., Holtzman, D. & Getz, G. S., 2000, In: Annals of the New York Academy of Sciences. 903, p. 167-175 9 p.Research output: Contribution to journal › Article › peer-review
180 Scopus citations -
Modulation of Aβ deposition in APP transgenic mice by an apolipoprotein E null background
Irizarry, M. C., Rebeck, G. W., Cheung, B., Bales, K., Paul, S. M., Holzman, D. & Hyman, B. T., 2000, In: Annals of the New York Academy of Sciences. 920, p. 171-178 8 p.Research output: Contribution to journal › Article › peer-review
54 Scopus citations -
No effect of apolipoprotein E on neuronal cell death due to excitotoxic and apoptotic agents in vitro and neonatal hypoxic ischaemia in vivo
Lendon, C. L., Han, B. H., Salimi, K., Fagan, A. M., Behrens, M. I., Muller, M. C. & Holtzman, D. M., 2000, In: European Journal of Neuroscience. 12, 7, p. 2235-2242 8 p.Research output: Contribution to journal › Article › peer-review
22 Scopus citations -
Role of tissue plasminogen activator receptor LRP in hippocampal long- term potentiation
Zhuo, M., Holtzman, D. M., Li, Y., Osaka, H., DeMaro, J., Jacquin, M. & Bu, G., Jan 15 2000, In: Journal of Neuroscience. 20, 2, p. 542-549 8 p.Research output: Contribution to journal › Article › peer-review
Open Access246 Scopus citations -
1999
Differential effects of cAMP in neurons and astrocytes. Role of B-raf
Dugan, L. L., Kim, J. S., Zhang, Y., Bart, R. D., Sun, Y., Holtzman, D. M. & Gutmann, D. H., Sep 3 1999, In: Journal of Biological Chemistry. 274, 36, p. 25842-25848 7 p.Research output: Contribution to journal › Article › peer-review
Open Access199 Scopus citations -
Expression of human apolipoprotein E reduces amyloid-β deposition in a mouse model of Alzheimer's disease
Holtzman, D. M., Bales, K. R., Wu, S., Bhat, P., Parsadanian, M., Fagan, A. M., Chang, L. K., Sun, Y. & Paul, S. M., Mar 1999, In: Journal of Clinical Investigation. 103, 6, p. R15-R21Research output: Contribution to journal › Article › peer-review
Open Access302 Scopus citations -
In situ atomic force microscopy study of Alzheimer's β-amyloid peptide on different substrates: New insights into mechanism of β-sheet formation
Kowalewski, T. & Holtzman, D. M., Mar 30 1999, In: Proceedings of the National Academy of Sciences of the United States of America. 96, 7, p. 3688-3693 6 p.Research output: Contribution to journal › Article › peer-review
Open Access378 Scopus citations -
In situ immunodetection of neuronal caspase-3 activation in Alzheimer disease
Selznick, L. A., Holtzman, D. M., Han, B. H., Gökden, M., Srinivasan, A. N., Johnson, E. M. & Roth, K. A., Sep 1999, In: Journal of neuropathology and experimental neurology. 58, 9, p. 1020-1026 7 p.Research output: Contribution to journal › Article › peer-review
Open Access150 Scopus citations -
Nitric oxide mediates cerebral ischemic tolerance in a neonatal rat model of hypoxic preconditioning
Gidday, J. M., Shah, A. R., Maceren, R. G., Wang, Q., Pelligrino, D. A., Holtzman, D. M. & Park, T. S., 1999, In: Journal of Cerebral Blood Flow and Metabolism. 19, 3, p. 331-340 10 p.Research output: Contribution to journal › Article › peer-review
Open Access208 Scopus citations -
Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and human apoE transgenic mice
Fagan, A. M., Holtzman, D. M., Munson, G., Mathur, T., Schneider, D., Chang, L. K., Getz, G. S., Reardon, C. A., Lukens, J., Shah, J. A. & LaDu, M. J., Oct 15 1999, In: Journal of Biological Chemistry. 274, 42, p. 30001-30007 7 p.Research output: Contribution to journal › Article › peer-review
Open Access184 Scopus citations -
1998
Bcl-x(L) is an antiapoptotic regulator for postnatal CNS neurons
Parsadanian, A. S., Cheng, Y., Keller-Peck, C. R., Holtzman, D. M. & Snider, W. D., 1998, In: Journal of Neuroscience. 18, 3, p. 1009-1019 11 p.Research output: Contribution to journal › Article › peer-review
Open Access234 Scopus citations -
Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury
Cheng, Y., Deshmukh, M., D'Costa, A., Demaro, J. A., Gidday, J. M., Shah, A., Sun, Y., Jacquin, M. F., Johnson, E. M. & Holtzman, D. M., May 1 1998, In: Journal of Clinical Investigation. 101, 9, p. 1992-1999 8 p.Research output: Contribution to journal › Article › peer-review
Open Access483 Scopus citations -
Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury
Fagan, A. M., Murphy, B. A., Patel, S. N., Kilbridge, J. F., Mobley, W. C., Bu, G. & Holtzman, D. M., Jun 1998, In: Experimental Neurology. 151, 2, p. 314-325 12 p.Research output: Contribution to journal › Article › peer-review
107 Scopus citations -
Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: Astrocyte-specific expression and differing biological effects of astrocyte- secreted apoE3 and apoE4 lipoproteins
Sun, Y., Wu, S., Bu, G., Onifade, M. K., Patel, S. N., LaDu, M. J., Fagan, A. M. & Holtzman, D. M., May 1 1998, In: Journal of Neuroscience. 18, 9, p. 3261-3272 12 p.Research output: Contribution to journal › Article › peer-review
Open Access207 Scopus citations -
Nascent astrocyte particles differ from lipoproteins in CSF
LaDu, M. J., Gilligan, S. M., Lukens, J. R., Cabana, V. G., Reardon, C. A., Van Eldik, L. J. & Holtzman, D. M., May 1998, In: Journal of Neurochemistry. 70, 5, p. 2070-2081 12 p.Research output: Contribution to journal › Article › peer-review
255 Scopus citations -
Nerve growth factor induces rapid increases in functional cell surface low density lipoprotein receptor-related protein
Bu, G., Sun, Y., Schwartz, A. L. & Holtzman, D. M., May 22 1998, In: Journal of Biological Chemistry. 273, 21, p. 13359-13365 7 p.Research output: Contribution to journal › Article › peer-review
Open Access63 Scopus citations -
Potential role of apoE in structural plasticity in the nervous system: Implications for disorders of the central nervous system
Holtzman, D. M. & Fagan, A. M., Aug 1998, In: Trends in Cardiovascular Medicine. 8, 6, p. 250-255 6 p.Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
1997
A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis
Schätzl, H. M., Laszlo, L., Holtzman, D. M., Tatzelt, J., Dearmond, S. J., Weiner, R. I., Mobley, W. C. & Prusiner, S. B., Nov 1997, In: Journal of virology. 71, 11, p. 8821-8831 11 p.Research output: Contribution to journal › Article › peer-review
Open Access247 Scopus citations -
A role for TrkA during maturation of striatal and basal forebrain cholinergic neurons in vivo
Fagan, A. M., Garber, M., Barbacid, M., Silos-Santiago, I. & Holtzman, D. M., 1997, In: Journal of Neuroscience. 17, 20, p. 7644-7654 11 p.Research output: Contribution to journal › Article › peer-review
Open Access128 Scopus citations -
Endogenous FGF-2 is important for cholinergic sprouting in the denervated hippocampus
Fagan, A. M., Suhr, S. T., Lucidi-Phillipi, C. A., Peterson, D. A., Holtzman, D. M. & Gage, F. H., 1997, In: Journal of Neuroscience. 17, 7, p. 2499-2511 13 p.Research output: Contribution to journal › Article › peer-review
Open Access77 Scopus citations -
High density lipoprotein decreases β-amyloid toxicity in cortical cell culture
Farhangrazi, Z. S., Ying, H., Bu, G., Dugan, L. L., Fagan, A. M., Choi, D. W. & Holtzman, D. M., 1997, In: NeuroReport. 8, 5, p. 1127-1130 4 p.Research output: Contribution to journal › Article › peer-review
26 Scopus citations -
Marked age-dependent neuroprotection by brain-derived neurotrophic factor against neonatal hypoxic-ischemic brain injury
Cheng, Y., Gidday, J. M., Yan, Q., Shah, A. R. & Holtzman, D. M., 1997, In: Annals of neurology. 41, 4, p. 521-529 9 p.Research output: Contribution to journal › Article › peer-review
175 Scopus citations -
Rapid suppression of free radical formation by nerve growth factor involves the mitogen-activated protein kinase pathway
Dugan, L. L., Creedon, D. J., Johnson, E. M. & Holtzman, D. M., Apr 15 1997, In: Proceedings of the National Academy of Sciences of the United States of America. 94, 8, p. 4086-4091 6 p.Research output: Contribution to journal › Article › peer-review
Open Access122 Scopus citations -
The low-density lipoprotein receptor-related protein, a multifunctional apolipoprotein E receptor, modulates hippocampal neurite development
Narita, M., Bu, G., Holtzman, D. M. & Schwartz, A. L., Feb 1997, In: Journal of Neurochemistry. 68, 2, p. 587-595 9 p.Research output: Contribution to journal › Article › peer-review
94 Scopus citations -
α2-macroglobulin complexes with and mediates the endocytosis of β- amyloid peptide via cell surface low-density lipoprotein receptor-related protein
Narita, M., Holtzman, D. M., Schwartz, A. L. & Bu, G., Nov 1997, In: Journal of Neurochemistry. 69, 5, p. 1904-1911 8 p.Research output: Contribution to journal › Article › peer-review
Open Access235 Scopus citations -
1996
A comprehensive study of the spatiotemporal pattern of β-amyloid precursor protein mRNA and protein in the rat brain: Lack of modulation by exogenously applied nerve growth factor
Neve, R. L., Valletta, J. S., Li, Y., Ventosa-Michelman, M., Holtzman, D. M. & Mobley, W. C., Jul 1996, In: Molecular Brain Research. 39, 1-2, p. 185-197 13 p.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein
Fagan, A. M., Bu, G., Sun, Y., Daugherty, A. & Holtzman, D. M., 1996, In: Journal of Biological Chemistry. 271, 47, p. 30121-30125 5 p.Research output: Contribution to journal › Article › peer-review
Open Access197 Scopus citations -
Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome
Holtzman, D. M., Santucci, D., Kilbridge, J., Chua-Couzens, J., Fontana, D. J., Daniels, S. E., Johnson, R. M., Chen, K., Sun, Y., Carlson, E., Alleva, E., Epstein, C. J. & Mobley, W. C., Nov 12 1996, In: Proceedings of the National Academy of Sciences of the United States of America. 93, 23, p. 13333-13338 6 p.Research output: Contribution to journal › Article › peer-review
Open Access409 Scopus citations -
Expression of neuronal-NOS in developing basal forebrain cholinergic neurons: Regulation by NGF
Holtzman, D. M., Lee, S., Li, Y., Chua-Couzens, J., Xia, H., Bredt, D. S. & Mobley, W. C., Jul 1996, In: Neurochemical Research. 21, 7, p. 861-868 8 p.Research output: Contribution to journal › Article › peer-review
35 Scopus citations