David Holtzman

2007

Abnormal glutamate homeostasis and impaired synaptic plasticity and learning in a mouse model of tuberous sclerosis complex

Zeng, L. H., Ouyang, Y., Gazit, V., Cirrito, J. R., Jansen, L. A., Ess, K. C., Yamada, K. A., Wozniak, D. F., Holtzman, D. M., Gutmann, D. H. & Wong, M., Nov 2007, In: Neurobiology of Disease. 28, 2, p. 184-196 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

108 Scopus citations

Acute stress increases interstitial fluid amyloid-β via corticotropin-releasing factor and neuronal activity

Kang, J. E., Cirrito, J. R., Dong, H., Csernansky, J. G. & Holtzman, D. M., Jun 19 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 25, p. 10673-10678 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

189 Scopus citations

Anti-Amyloid-B Immunotherapy as a Treatment for Alzheimer's Disease

Cirrito, J. R. & Holtzmant, D. M., Dec 27 2007, CNS Regeneration: Basic Science and Clinical Advances. Elsevier, p. 295-318 24 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Apolipoprotein E levels in cerebrospinal fluid and the effects of ABCAI polymorphisms

Wahrle, S. E., Shah, A. R., Fagan, A. M., Smemo, S., Kauwe, J. S. K., Grupe, A., Hinrichs, A., Mayo, K., Jiang, H., Thal, L. J., Goate, A. M. & Holtzman, D. M., 2007, In: Molecular neurodegeneration. 2, 1, 7.

Research output: Contribution to journal › Article › peer-review

Open Access

69 Scopus citations

Cerebrospinal fluid tau/β-amyloid₄₂ ratio as a prediction of cognitive decline in nondemented older adults

Fagan, A. M., Roe, C. M., Xiong, C., Mintun, M. A., Morris, J. C. & Holtzman, D. M., Mar 2007, In: Archives of neurology. 64, 3, p. 343-349 7 p.

Research output: Contribution to journal › Article › peer-review

779 Scopus citations

Detection of traumatic axonal injury with diffusion tensor imaging in a mouse model of traumatic brain injury

Mac Donald, C. L., Dikranian, K., Song, S. K., Bayly, P. V., Holtzman, D. M. & Brody, D. L., May 2007, In: Experimental Neurology. 205, 1, p. 116-131 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

257 Scopus citations

Diffusion tensor imaging reliably detects experimental traumatic axonal injury and indicates approximate time of injury

Mac Donald, C. L., Dikranian, K., Bayly, P., Holtzman, D. & Brody, D., Oct 31 2007, In: Journal of Neuroscience. 27, 44, p. 11869-11876 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

371 Scopus citations

Electromagnetic controlled cortical impact device for precise, graded experimental traumatic brain injury

Brody, D. L., Mac Donald, C., Kessens, C. C., Yuede, C., Parsadanian, M., Spinner, M., Kim, E., Schwetye, K. E., Holtzman, D. M. & Bayly, P. V., Apr 2007, In: Journal of neurotrauma. 24, 4, p. 657-673 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

172 Scopus citations

Erratum: National Institute of Neurological Disorders and Stroke-Canadian Stroke Network Vascular Cognitive Impairment Harmonization Standards (Stroke (2006) 37, 9, (2220-2241))

Hachinski, V., Iadecola, C., Petersen, R. C., Breteler, M. M., Nyenhuis, D. L., Black, S. E., Powers, W. J., DeCarli, C., Merino, J. G., Kalaria, R. N., Vinters, H. V., Holtzman, D. M., Rosenberg, G. A., Wallin, A., Dichgans, M., Marler, J. R. & Leblanc, G. G., Mar 2007, In: Stroke. 38, 3, p. 1118 1 p.

Research output: Contribution to journal › Comment/debate

2 Scopus citations

Extreme cerebrospinal fluid amyloid β levels identify family with late-onset Alzheimer's disease presenilin 1 mutation

Kauwe, J. S. K., Jacquart, S., Chakraverty, S., Wang, J., Mayo, K., Fagan, A. M., Holtzman, D. M., Morris, J. C. & Goate, A. M., May 2007, In: Annals of neurology. 61, 5, p. 446-453 8 p.

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Fluctuations of CSF amyloid-β levels: Implications for a diagnostic and therapeutic biomarker

Bateman, R. J., Wen, G., Morris, J. C. & Holtzman, D. M., Feb 2007, In: Neurology. 68, 9, p. 666-669 4 p.

Research output: Contribution to journal › Article › peer-review

226 Scopus citations

Identification and validation of novel CSF biomarkers for early stages of Alzheimer's disease

Hu, Y., Hosseini, A., Kauwe, J. S. K., Gross, J., Cairns, N. J., Goate, A. M., Fagan, A. M., Townsend, R. R. & Holtzman, D. M., Nov 2007, In: Proteomics - Clinical Applications. 1, 11, p. 1373-1384 12 p.

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy

Farris, W., Schütz, S. G., Cirrito, J. R., Shankar, G. M., Sun, X., George, A., Leissring, M. A., Walsh, D. M., Wei, Q. Q., Holtzman, D. M. & Selkoe, D. J., Jul 2007, In: American Journal of Pathology. 171, 1, p. 241-251 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

140 Scopus citations

Medication use as a confounding factor in the use of the cerebrospinal fluid tau/β-amyloid₄₂ ratio: Reply [4]

Fagan, A. M., Roe, C. M., Xiong, C., Mintun, M. A., Morris, J. C. & Holtzman, D. M., Sep 2007, In: Archives of neurology. 64, 9, p. 1357-1359 3 p.

Research output: Contribution to journal › Letter › peer-review

Pittsburgh compound B retention and verification of amyloid deposition

Holtzman, D. M., Mar 1 2007, In: Archives of neurology. 64, 3, p. 315-316 2 p.

Research output: Contribution to journal › Editorial

4 Scopus citations

Pomegranate polyphenols and resveratrol protect the neonatal brain against hypoxic-ischemic injury

West, T., Atzeva, M. & Holtzman, D. M., Aug 2007, In: Developmental Neuroscience. 29, 4-5, p. 363-372 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

154 Scopus citations

Quantitative analysis of amyloid-β peptides in cerebrospinal fluid using immunoprecipitation and MALDI-Tof mass spectrometry

Gelfanova, V., Higgs, R. E., Dean, R. A., Holtzman, D. M., Farlow, M. R., Siemers, E. R., Boodhoo, A., Qian, Y. W., He, X., Jin, Z., Fisher, D. I., Cox, K. I. & Hale, J. E., Jun 2007, In: Briefings in Functional Genomics and Proteomics. 6, 2, p. 149-158 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

Role of a β Transport and clearance in the pathogenesis and treatment of alzheimer's disease

Holtzman, D. M. & Zlokovic, B., 2007, Alzheimer's Disease: Advances in Genetics, Molecular and Cellular Biology. Springer US, p. 179-198 20 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

14 Scopus citations

Stable Isotope Labeling Tandem Mass Spectrometry (SILT) to Quantify Protein Production and Clearance Rates

Bateman, R. J., Munsell, L. Y., Chen, X., Holtzman, D. M. & Yarasheski, K. E., Jun 2007, In: Journal of the American Society for Mass Spectrometry. 18, 6, p. 997-1006 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

59 Scopus citations

Transport pathways for clearance of human Alzheimer's amyloid β-peptide and apolipoproteins E and J in the mouse central nervous system

Bell, R. D., Sagare, A. P., Friedman, A. E., Bedi, G. S., Holtzman, D. M., Deane, R. & Zlokovic, B. V., May 16 2007, In: Journal of Cerebral Blood Flow and Metabolism. 27, 5, p. 909-918 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

566 Scopus citations

2006

Amyloid-β immunotherapies in mice and men

Brendza, R. P. & Holtzman, D. M., Apr 2006, In: Alzheimer disease and associated disorders. 20, 2, p. 118-123 6 p.

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD

Momeni, P., Schymick, J., Jain, S., Cookson, M. R., Cairns, N. J., Greggio, E., Greenway, M. J., Berger, S., Pickering-Brown, S., Chiò, A., Fung, H. C., Holtzman, D. M., Huey, E. D., Wassermann, E. M., Adamson, J., Hutton, M. L., Rogaeva, E., St. George-Hyslop, P., Rothstein, J. D. & Hardiman, O. & 4 others, Grafman, J., Singleton, A., Hardy, J. & Traynor, B. J., 2006, In: BMC Neurology. 6, 44.

Research output: Contribution to journal › Article › peer-review

Open Access

74 Scopus citations

Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Aβ42 accumulation in amyloid model mice

Zerbinatti, C. V., Wahrle, S. E., Kim, H., Cam, J. A., Bales, K., Paul, S. M., Holtzman, D. M. & Bu, G., Nov 24 2006, In: Journal of Biological Chemistry. 281, 47, p. 36180-36186 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

111 Scopus citations

Caspase-3 deficiency during development increases vulnerability to hypoxic-ischemic injury through caspase-3-independent pathways

West, T., Atzeva, M. & Holtzman, D. M., Jun 2006, In: Neurobiology of Disease. 22, 3, p. 523-537 15 p.

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Cell death mechanism and protective effect of erythropoietin after focal ischemia in the whisker-barrel cortex of neonatal rats

Wei, L., Han, B. H., Li, Y., Keogh, C. L., Holtzman, D. M. & Shan, P. Y., Apr 2006, In: Journal of Pharmacology and Experimental Therapeutics. 317, 1, p. 109-116 8 p.

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Down’s Syndrome, Alzheimer’s Disease, and Dementia

Loren, D. J. & Holtzman, D. M., Jan 1 2006, Handbook of Dementing Illnesses, Second Edition. CRC Press, p. 209-220 12 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Effects of a γ-secretase inhibitor in a randomized study of patients with Alzheimer disease

Siemers, E. R., Quinn, J. F., Kaye, J., Farlow, M. R., Porsteinsson, A., Tariot, P., Zoulnouni, P., Galvin, J. E., Holtzman, D. M., Knopman, D. S., Satterwhite, J., Gonzales, C., Dean, R. A. & May, P. C., Feb 2006, In: Neurology. 66, 4, p. 602-604 3 p.

Research output: Contribution to journal › Article › peer-review

294 Scopus citations

Expectations and challenges in the therapeutic use of neurotrophic factors

Kotzbauer, P. T. & Holtzman, D. M., Mar 2006, In: Annals of neurology. 59, 3, p. 444-447 4 p.

Research output: Contribution to journal › Editorial

17 Scopus citations

Handbook of Dementing Illnesses, Second Edition

Morris, J., Galvin, J. E. & Holtzman, D. M., Jan 1 2006, CRC Press. 522 p.

Research output: Book/Report › Book › peer-review

3 Scopus citations

Human amyloid-β synthesis and clearance rates as measured in cerebrospinal fluid in vivo

Bateman, R. J., Munsell, L. Y., Morris, J. C., Swarm, R., Yarasheski, K. E. & Holtzman, D. M., Jul 2006, In: Nature medicine. 12, 7, p. 856-861 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

519 Scopus citations

Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta;₄₂ in humans

Fagan, A. M., Mintun, M. A., Mach, R. H., Lee, S. Y., Dence, C. S., Shah, A. R., LaRossa, G. N., Spinner, M. L., Klunk, W. E., Mathis, C. A., DeKosky, S. T., Morris, J. C. & Holtzman, D. M., Mar 2006, In: Annals of neurology. 59, 3, p. 512-519 8 p.

Research output: Contribution to journal › Article › peer-review

1104 Scopus citations

Matrix metalloproteinase-9 degrades amyloid-β fibrils in vitro and compact plaques in situ

Yan, P., Hu, X., Song, H., Yin, K., Bateman, R. J., Cirrito, J. R., Xiao, Q., Hsu, F. F., Turk, J. W., Xu, J., Hsu, C. Y., Holtzman, D. M. & Lee, J. M., Aug 25 2006, In: Journal of Biological Chemistry. 281, 34, p. 24566-24574 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

315 Scopus citations

Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-β peptide catabolism

Yin, K. J., Cirrito, J. R., Yan, P., Hu, X., Xiao, Q., Pan, X., Bateman, R., Song, H., Hsu, F. F., Turk, J., Xu, J., Hsu, C. Y., Mills, J. C., Holtzman, D. M. & Lee, J. M., Oct 25 2006, In: Journal of Neuroscience. 26, 43, p. 10939-10948 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

309 Scopus citations

Morris water maze search strategy analysis in PDAPP mice before and after experimental traumatic brain injury

Brody, D. L. & Holtzman, D. M., Feb 2006, In: Experimental Neurology. 197, 2, p. 330-340 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

164 Scopus citations

National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards

Hachinski, V., Iadecola, C., Petersen, R. C., Breteler, M. M., Nyenhuis, D. L., Black, S. E., Powers, W. J., DeCarli, C., Merino, J. G., Kalaria, R. N., Vinters, H. V., Holtzman, D. M., Rosenberg, G. A., Dichgans, M., Marler, J. R. & Leblanc, G. G., Sep 2006, In: Stroke. 37, 9, p. 2220-2241 22 p.

Research output: Contribution to journal › Article › peer-review

1353 Scopus citations

Plasma cortisol and progression of dementia in subjects with Alzheimer-type dementia

Csernansky, J. G., Dong, H., Fagan, A. M., Wang, L., Xiong, C., Holtzman, D. M. & Morris, J. C., Dec 2006, In: American Journal of Psychiatry. 163, 12, p. 2164-2169 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

361 Scopus citations

Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer's disease

Hartman, R. E., Shah, A., Fagan, A. M., Schwetye, K. E., Parsadanian, M., Schulman, R. N., Finn, M. B. & Holtzman, D. M., Dec 2006, In: Neurobiology of Disease. 24, 3, p. 506-515 10 p.

Research output: Contribution to journal › Article › peer-review

313 Scopus citations

Quantitative analysis of amyloid β peptides in cerebrospinal fluid of Alzheimer's disease patients by immunoaffinity purification and stable isotope dilution liquid chromatography/negative electrospray ionization tandem mass spectrometry

Oe, T., Ackermann, B. L., Inoue, K., Berna, M. J., Garner, C. O., Gelfanova, V., Dean, R. A., Siemers, E. R., Holtzman, D. M., Farlow, M. R. & Blair, I. A., 2006, In: Rapid Communications in Mass Spectrometry. 20, 24, p. 3723-3735 13 p.

Research output: Contribution to journal › Article › peer-review

140 Scopus citations

Role of the Menkes copper-transporting ATPase in NMDA receptor-mediated neuronal toxicity

Schlief, M. L., West, T., Craig, A. M., Holtzman, D. M. & Gitlin, J. D., Oct 3 2006, In: Proceedings of the National Academy of Sciences of the United States of America. 103, 40, p. 14919-14924 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

166 Scopus citations

2005

Anti-Aβ antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice

Brendza, R. P., Bacskai, B. J., Cirrito, J. R., Simmons, K. A., Skoch, J. M., Klunk, W. E., Mathis, C. A., Bales, K. R., Paul, S. M., Hyman, B. T. & Holtzman, D. M., Feb 2005, In: Journal of Clinical Investigation. 115, 2, p. 428-433 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

176 Scopus citations

Calcium-stimulated adenylyl cyclases modulate ethanol-induced neurodegeneration in the neonatal brain

Maas, J. W., Indacochea, R. A., Muglia, L. M., Tran, T. T., Vogt, S. K., West, T., Benz, A., Shute, A. A., Holtzman, D. M., Mennerick, S., Olney, J. W. & Muglia, L. J., Mar 2 2005, In: Journal of Neuroscience. 25, 9, p. 2376-2385 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid

Hu, Y., Malone, J. P., Fagan, A. M., Townsend, R. R. & Holtzman, D. M., Dec 2005, In: Molecular and Cellular Proteomics. 4, 12, p. 2000-2005 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

107 Scopus citations

Deletion of Abca1 increases Aβ deposition in the PDAPP transgenic mouse model of Alzheimer disease

Wahrle, S. E., Jiang, H., Parsadanian, M., Hartman, R. E., Bales, K. R., Paul, S. M. & Holtzman, D. M., Dec 30 2005, In: Journal of Biological Chemistry. 280, 52, p. 43236-43242 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

284 Scopus citations

Detection of age-dependent brain injury in a mouse model of brain amyloidosis associated with Alzheimer's disease using magnetic resonance diffusion tensor imaging

Sun, S. W., Song, S. K., Harms, M. P., Lin, S. J., Holtzman, D. M., Merchant, K. M. & Kotyk, J. J., Jan 2005, In: Experimental Neurology. 191, 1, p. 77-85 9 p.

Research output: Contribution to journal › Article › peer-review

112 Scopus citations

Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid β

Racke, M. M., Boone, L. I., Hepburn, D. L., Parsadainian, M., Bryan, M. T., Ness, D. K., Piroozi, K. S., Jordan, W. H., Brown, D. D., Hoffman, W. P., Holtzman, D. M., Bales, K. R., Gitter, B. D., May, P. C., Paul, S. M. & DeMattos, R. B., Jan 19 2005, In: Journal of Neuroscience. 25, 3, p. 629-636 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

306 Scopus citations

Human apolipoprotein E4 alters the amyloid-β 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model

Fryer, J. D., Simmons, K., Parsadanian, M., Bales, K. R., Paul, S. M., Sullivan, P. M. & Holtzman, D. M., Mar 16 2005, In: Journal of Neuroscience. 25, 11, p. 2803-2810 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

243 Scopus citations

IgG-assisted age-dependent clearance of Alzheimer's amyloid β peptide by the blood-brain barrier neonatal Fc receptor

Deane, R., Sagare, A., Hamm, K., Parisi, M., LaRue, B., Guo, H., Wu, Z., Holtzman, D. M. & Zlokovic, B. V., Dec 14 2005, In: Journal of Neuroscience. 25, 50, p. 11495-11503 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

208 Scopus citations

Immunization therapy for Alzheimer disease?

Bennett, D. A. & Holtzman, D. M., Jan 11 2005, In: Neurology. 64, 1, p. 10-12 3 p.

Research output: Contribution to journal › Editorial

11 Scopus citations

Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury

Loren, D. J., Seeram, N. P., Schulman, R. N. & Holtzman, D. M., Jun 2005, In: Pediatric research. 57, 6, p. 858-864 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

160 Scopus citations

Matrix metalloproteinase-9 in cerebral-amyloid-angiopathy-related hemorrhage

Lee, J. M., Yin, K., Hsin, I., Chen, S., Fryer, J. D., Holtzman, D. M., Hsu, C. Y. & Xu, J., Mar 15 2005, In: Journal of the Neurological Sciences. 229-230, p. 249-254 6 p.

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

David Holtzman

Research output

Search results