Personal profile
Research interests
The lab of Dr. David Holtzman focuses on Alzheimer's disease, in particular understanding the metabolism of the amyloid-beta peptide in the CNS and plasma. The Holtman lab has demonstrated how endogenous and exogenous Abeta binding molecules play key roles in Alzheimer's disease (AD) pathogenesis. Utilization of transgenic and knockout mice has demonstrated that apoE and a molecule called apoJ/clusterin play critical roles in vivo in the formation of amyloid and its toxicity and that apoE4 is most likely an AD risk factor via its effects on Abeta conformation and toxicity. Recent work with anti-Abeta antibodies demonstrates a novel mechanism in which antibodies can act as an "Abeta sink" in the plasma and has exciting potential to lead to new diagnostic and treatment methods for AD. More recently, the lab is attempting to identify antecedent biomarkers for AD, particularly in human CSF.
Clinical interests
Neurology, molecular biology, pharmacology, nervous system, Alzheimer's disease, memory, brain research, cerebral blood flow, metabolism, neuroscience, lipid research, neuron, mental retardation, Down's syndrome, neonatal hypoxic-ischemia, brain disorders, spinal fluid.
Available to Mentor:
- PhD Students
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Collaborations and top research areas from the last five years
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Analyses of plasma multi-omic data across ancestries identify novel pathways implicated in Alzheimer's disease
Yang, C., Timsina, J., Liu, M., Budde, J., Kohlfeld, P., Brock, W., Morris, J. C., Holtzman, D. M., Sung, Y. J. & Cruchaga, C., Feb 2026, In: Alzheimer's and Dementia. 22, 2, e71164.Research output: Contribution to journal › Article › peer-review
Open Access -
APOE-stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease
Li, F., Chen, Y., Western, D., Ali, M., Liu, M., Gong, K., Xu, Y., Lowery, J., Holtzman, D. M., Robins, C., Eicher, J. D., Huang, Y. N., Liu, S. W., Park, T., Saykin, A. J., Nho, K., Moqri, M., Mohs, R. C., Farinas, A. & Moran-Losada, P. & 3 others, , Apr 13 2026, In: Advanced Science. 13, 21, e13872.Research output: Contribution to journal › Article › peer-review
Open Access -
Context matters: Conflicting roles of interferon-γ signaling in CNS diseases
Nulman, J., Ulrich, J. D. & Holtzman, D. M., Feb 2026, In: Current Opinion in Neurobiology. 96, 103149.Research output: Contribution to journal › Review article › peer-review
Open Access -
Cortical asymmetry in autosomal dominant Alzheimer’s disease progression
Pérez-Millan, A., Falgàs, N., Bosch, B., Borrego-Écija, S., Antonell, A., Fernández-Villullas, G., Esteller-Gauxax, D., Tort-Merino, A., Bargalló, N., Balasa, M., Lladó, A., Aguillon, D., Chrem, P., Day, G. S., Devenney, E., Huey, E. D., Ikeuchi, T., Jucker, M., Kasuga, K. & Vöglein, J. & 119 others, , 2026, In: Brain Communications. 8, 1, fcaf488.Research output: Contribution to journal › Article › peer-review
Open Access -
Inducible deletion of DGAT1 and 2 from microglia exacerbates neurodegeneration and endolysosomal lipid accumulation in male PS19 mice
Tabor, G. T., Litvinchuk, A., Chen, Y., Allison, A., Sun, E. W., van Lengerich, B., Davis, S. S., West, E., Schlachetzki, J. C. M., Zeng, C., Hu, H., Lin, P. B., Sharma, P., Chen, X., Parhizkar, S., Song, S., Bao, X., Senthil, L., Iyer, A. K. & You, S. F. & 17 others, , Jan 27 2026, In: Cell Reports. 45, 1, 116841.Research output: Contribution to journal › Article › peer-review
Open Access