Willing to Mentor

    Available to Mentor:

    PhD/MSTP Students

    • 132286
      Citations
    1988 …2025

    Research activity per year

    Personal profile

    Research interests

    The lab of Dr. David Holtzman focuses on Alzheimer's disease, in particular understanding the metabolism of the amyloid-beta peptide in the CNS and plasma. The Holtman lab has demonstrated how endogenous and exogenous Abeta binding molecules play key roles in Alzheimer's disease (AD) pathogenesis. Utilization of transgenic and knockout mice has demonstrated that apoE and a molecule called apoJ/clusterin play critical roles in vivo in the formation of amyloid and its toxicity and that apoE4 is most likely an AD risk factor via its effects on Abeta conformation and toxicity. Recent work with anti-Abeta antibodies demonstrates a novel mechanism in which antibodies can act as an "Abeta sink" in the plasma and has exciting potential to lead to new diagnostic and treatment methods for AD. More recently, the lab is attempting to identify antecedent biomarkers for AD, particularly in human CSF.

    Clinical interests

    Neurology, molecular biology, pharmacology, nervous system, Alzheimer's disease, memory, brain research, cerebral blood flow, metabolism, neuroscience, lipid research, neuron, mental retardation, Down's syndrome, neonatal hypoxic-ischemia, brain disorders, spinal fluid.

    Available to Mentor:

    • PhD/MSTP Students

    Fingerprint

    Dive into the research topics where David Holtzman is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
    • 1 Similar Profiles

    Collaborations and top research areas from the last five years

    Recent external collaboration on country/territory level. Dive into details by clicking on the dots or