David Holtzman

Andrew B. and Gretchen P. Jones Professor of Neurology, Head of the Department of Neurology, Professor of Developmental Biology

    • 71754 Citations
    1988 …2020

    Research output per year

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    Personal profile

    Research interests

    The lab of Dr. David Holtzman focuses on Alzheimer's disease, in particular understanding the metabolism of the amyloid-beta peptide in the CNS and plasma. The Holtman lab has demonstrated how endogenous and exogenous Abeta binding molecules play key roles in Alzheimer's disease (AD) pathogenesis. Utilization of transgenic and knockout mice has demonstrated that apoE and a molecule called apoJ/clusterin play critical roles in vivo in the formation of amyloid and its toxicity and that apoE4 is most likely an AD risk factor via its effects on Abeta conformation and toxicity. Recent work with anti-Abeta antibodies demonstrates a novel mechanism in which antibodies can act as an "Abeta sink" in the plasma and has exciting potential to lead to new diagnostic and treatment methods for AD. More recently, the lab is attempting to identify antecedent biomarkers for AD, particularly in human CSF.

    Areas of Clinical Interest

    Neurology, molecular biology, pharmacology, nervous system, Alzheimer's disease, memory, brain research, cerebral blood flow, metabolism, neuroscience, lipid research, neuron, mental retardation, Down's syndrome, neonatal hypoxic-ischemia, brain disorders, spinal fluid.

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    Research Output

    25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner

    Wong, M. Y., Lewis, M., Doherty, J. J., Shi, Y., Cashikar, A. G., Amelianchik, A., Tymchuk, S., Sullivan, P. M., Qian, M., Covey, D. F., Petsko, G. A., Holtzman, D. M., Paul, S. M., Paul, S. M. & Luo, W., Jun 17 2020, In : Journal of Neuroinflammation. 17, 1, 192.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Alternatives to amyloid for Alzheimer's disease therapies—a symposium report

    Cable, J., Holtzman, D. M., Hyman, B. T., Tansey, M. G., Colonna, M., Kellis, M., Brinton, R. D., Albert, M., Wellington, C. L., Sisodia, S. S. & Tanzi, R. E., Jul 3 2020, In : Annals of the New York Academy of Sciences. 1475, 1, p. 3-14 12 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Amyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer's Disease

    Dominantly Inherited Alzheimer Network (DIAN) & PREVENT-AD Research Group, 2020, (Accepted/In press) In : Biological Psychiatry.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    APOE genotype regulates pathology and disease progression in synucleinopathy

    Davis, A. A., Inman, C. E., Wargel, Z. M., Dube, U., Freeberg, B. M., Galluppi, A., Haines, J. N., Dhavale, D. D., Miller, R., Choudhury, F. A., Sullivan, P. M., Cruchaga, C., Perlmutter, J. S., Ulrich, J. D., Benitez, B. A., Kotzbauer, P. T. & Holtzman, D. M., Feb 5 2020, In : Science translational medicine. 12, 529, eaay3069.

    Research output: Contribution to journalArticle

  • 9 Scopus citations

    A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease

    the Dominantly Inherited Alzheimer Network, Mar 1 2020, In : Nature medicine. 26, 3, p. 398-407 10 p.

    Research output: Contribution to journalArticle

  • 18 Scopus citations