David Gutmann

Professor of Neurology, Director - Neurofibromatosis Center, Professor of Genetics, Professor of Neurological Surgery, Professor of Pediatrics, Donald O. Schnuck Family Professor of Neurology

    Willing to Mentor

    Available to Mentor:

    Undergraduate Students, Post-Baccalaureate Students, PhD/MSTP Students, Health Professions (Medical, OT, PT, Dental, Audiology, etc.) Students, Postdocs, Residents and Fellows

    • 37484
    1976 …2022

    Research activity per year

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    Personal profile

    Research interests

    The development and maintenance of the mammalian nervous system is regulated by a highly orchestrated series of cellular and molecular events. When these processes become disrupted by genetic mutation, disorders of the brain and nerves arise. One of the most common of these neurogenetic disorders is Neurofibromatosis type 1 (NF1), in which children are at risk for brain and nerve tumors, vision loss, learning problems, autism, and developmental disabilities.

    For the past 25 years, the Gutmann laboratory has focused on discovering the genomic, genetic, cellular and molecular determinants that cause nervous system dysfunction in people with NF1 using a combination of novel genetically engineered mice and human induced pluripotent stem cells. The goal of this work is not only to establish new treatments for individuals with NF1, but also to better understand similar medical problems in the general population. Moreover, as a neurologist who cares for children and adults with NF1, Dr. Gutmann seeks to identify the factors that underlie nervous system disease heterogeneity relevant to the implementation of precision (personalized) medicine strategies.

    Clinical interests

    Dr. Gutmann serves as Vice Chair for Research Affairs in the Department of Neurology, and Director of The Washington University Neurofibromatosis (NF) Center. Dr. Gutmann is an international expert in the care of people with neurofibromatosis (NF). More about NF can be found on the Washington University NF Center web site http://nfcenter.wustl.edu


    We welcome dedicated trainees at all levels, from undergraduates to graduate students and beyond, to participate in laboratory research and development opportunities through our laboratory and its affiliated programs. 

    Available to Mentor:

    • Undergraduate Students
    • Post-Baccalaureate Students
    • PhD/MSTP Students
    • Health Professions Students
    • Postdocs
    • Residents and Fellows


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