• 34883 Citations
1988 …2020

Research output per year

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Personal profile

Research interests

Our interest is in the development of virus-based therapeutics for inherited and acquired disorders. In this regard, both gene therapy and virotherapy approaches have been applied principally for the context of neoplastic diseases. Our group embodies a strong bench-to-bed translational fucus whereby laboratory-derived strategies are applied for the context of human Phase 1 clinical trials. We also seek to develop useful surrogate endpoint analyses (ex. imaging) that will enable us to gain the maximal amount of useful information from these human trials.

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Research Output

A new gorilla adenoviral vector with natural lung tropism avoids liver toxicity and is amenable to capsid engineering and vector retargeting

Lu, Z. H., Dmitriev, I. P., Brough, D. E., Kashentseva, E. A., Li, J. & Curiel, D. T., May 1 2020, In : Journal of virology. 94, 10, e00265-20.

Research output: Contribution to journalArticle

Open Access
  • A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2

    Hassan, A. O., Kafai, N. M., Dmitriev, I. P., Fox, J. M., Smith, B. K., Harvey, I. B., Chen, R. E., Winkler, E. S., Wessel, A. W., Case, J. B., Kashentseva, E., McCune, B. T., Bailey, A. L., Zhao, H., VanBlargan, L. A., Dai, Y. N., Ma, M., Adams, L. J., Shrihari, S., Danis, J. E. & 11 others, Gralinski, L. E., Hou, Y. J., Schäfer, A., Kim, A. S., Keeler, S. P., Weiskopf, D., Baric, R. S., Holtzman, M. J., Fremont, D. H., Curiel, D. T. & Diamond, M. S., Oct 1 2020, In : Cell. 183, 1, p. 169-184.e13

    Research output: Contribution to journalArticle

    Open Access
  • Erratum: Enhanced Delivery of Oncolytic Adenovirus by Neural Stem Cells for Treatment of Metastatic Ovarian Cancer (Molecular Therapy - Oncolytics (2019) 12 (79–92), (S237277051830038X), (10.1016/j.omto.2018.12.003))

    Mooney, R., Majid, A. A., Batalla-Covello, J., Machado, D., Liu, X., Gonzaga, J., Tirughana, R., Hammad, M., Dellinger, T. H., Lesniak, M. S., Curiel, D. T. & Aboody, K. S., Jun 26 2020, In : Molecular Therapy - Oncolytics. 17, 1 p.

    Research output: Contribution to journalComment/debate

    Open Access
  • Targeting tumor neoangiogenesis via targeted adenoviral vector to achieve effective cancer gene therapy for disseminated neoplastic disease

    Lee, M., Lu, Z. H., Li, J., Kashentseva, E. A., Dmitriev, I. P., Mendonca, S. A. & Curiel, D. T., Mar 2020, In : Molecular Cancer Therapeutics. 19, 3, p. 966-971 6 p.

    Research output: Contribution to journalArticle

    Open Access
  • Understanding and addressing barriers to successful adenovirus-based virotherapy for ovarian cancer

    Gonzalez-Pastor, R., Goedegebuure, P. S. & Curiel, D. T., 2020, (Accepted/In press) In : Cancer gene therapy.

    Research output: Contribution to journalReview article

    Open Access