Darja Karpova

2023

Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax

Waclawiczek, A., Leppä, A. M., Renders, S., Stumpf, K., Reyneri, C., Betz, B., Janssen, M., Shahswar, R., Donato, E., Karpova, D., Thiel, V., Unglaub, J. M., Grabowski, S., Gryzik, S., Vierbaum, L., Schlenk, R. F., Röllig, C., Hundemer, M., Pabst, C., Heuser, M., & 4 othersRaffel, S., Müller-Tidow, C., Sauer, T. & Trumpp, A., 2023, In: Cancer discovery. 13, 6, p. 1408-1427 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Retained functional normal and preleukemic HSCs at diagnosis are associated with good prognosis in DNMT3A^mutNPM1^mut AMLs

Donato, E., Correia, N., Andresen, C., Karpova, D., Würth, R., Klein, C., Sohn, M., Przybylla, A., Zeisberger, P., Rothfelder, K., Salih, H., Bonig, H., Stasik, S., Röllig, C., Dolnik, A., Bullinger, L., Buchholz, F., Thiede, C., Hübschmann, D. & Trumpp, A., Mar 28 2023, In: Blood Advances. 7, 6, p. 1011-1018 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2019

Hematopoietic-extrinsic cues dictate circadian redistribution of mature and immature hematopoietic cells in blood and spleen

Stenzinger, M., Karpova, D., Unterrainer, C., Harenkamp, S., Wiercinska, E., Hoerster, K., Pfeffer, M., Maronde, E. & Bonig, H., Sep 2019, In: Cells. 8, 9, 1033.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Mobilized peripheral blood: An updated perspective

DiPersio, J. F., Karpova, D. & Rettig, M. P., 2019, In: F1000Research. 8, 2125.

Research output: Contribution to journal › Review article › peer-review

Open Access

23 Scopus citations

Modest and nonessential roles of the endocannabinoid system in immature hematopoiesis of mice

Danner, E., Hoffmann, F., Lee, S. Y., Cordes, F., Orban, S., Dauber, K., Chudziak, D., Spohn, G., Wiercinska, E., Tast, B., Karpova, D. & Bonig, H., Oct 2019, In: Experimental Hematology. 78, p. 35-45 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells

Karpova, D., Rettig, M. P., Ritchey, J., Cancilla, D., Christ, S., Gehrs, L., Chendamarai, E., Evbuomwan, M. O., Holt, M., Zhang, J., Abou-Ezzi, G., Celik, H., Wiercinska, E., Yang, W., Gao, F., Eissenberg, L. G., Heier, R. F., Arnett, S. D., Meyers, M. J., Prinsen, M. J., & 7 othersGriggs, D. W., Trumpp, A., Ruminski, P. G., Morrow, D. M., Bonig, H. B., Link, D. C. & DiPersio, J. F., 2019, In: Journal of Clinical Investigation. 129, 7, p. 2745-2759 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

TGF-β Signaling Plays an Essential Role in the Lineage Specification of Mesenchymal Stem/Progenitor Cells in Fetal Bone Marrow

Abou-Ezzi, G., Supakorndej, T., Zhang, J., Anthony, B., Krambs, J., Celik, H., Karpova, D., Craft, C. S. & Link, D. C., Jul 9 2019, In: Stem Cell Reports. 13, 1, p. 48-60 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

2018

JARID2 Functions as a Tumor Suppressor in Myeloid Neoplasms by Repressing Self-Renewal in Hematopoietic Progenitor Cells

Celik, H., Koh, W. K., Kramer, A. C., Ostrander, E. L., Mallaney, C., Fisher, D. A. C., Xiang, J., Wilson, W. C., Martens, A., Kothari, A., Fishberger, G., Tycksen, E., Karpova, D., Duncavage, E. J., Lee, Y., Oh, S. T. & Challen, G. A., Nov 12 2018, In: Cancer Cell. 34, 5, p. 741-756.e8

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

OMIP-042: 21-color flow cytometry to comprehensively immunophenotype major lymphocyte and myeloid subsets in human peripheral blood

Staser, K. W., Eades, W., Choi, J., Karpova, D. & DiPersio, J. F., Feb 1 2018, In: Cytometry Part A. 93, 2, p. 186-189 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

2017

Azacitidine mitigates graft-versus-host disease via differential effects on the proliferation of T effectors and natural regulatory T cells in vivo

Cooper, M. L., Choi, J., Karpova, D., Vij, K., Ritchey, J., Schroeder, M. A. & DiPersio, J. F., May 1 2017, In: Journal of Immunology. 198, 9, p. 3746-3754 9 p.

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Continuous blockade of CXCR4 results in dramatic mobilization and expansion of hematopoietic stem and progenitor cells

Karpova, D., Ritchey, J. K., Holt, M. S., Abou-Ezzi, G., Monlish, D., Batoon, L., Millard, S., Spohn, G., Wiercinska, E., Chendamarai, E., Yang, W., Christ, S., Gehrs, L., Schuettpelz, L. G., Dembowsky, K., Pettit, A. R., Rettig, M. P., Bonig, H. & Di Persio, J. F., May 25 2017, In: Blood. 129, 21, p. 2939-2949 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

Mobilization of hematopoietic stem cells with the novel CXCR4 antagonist POL6326 (balixafortide) in healthy volunteers-results of a dose escalation trial

Karpova, D., Bräuninger, S., Wiercinska, E., Krämer, A., Stock, B., Graff, J., Martin, H., Wach, A., Escot, C., Douglas, G., Romagnoli, B., Chevalier, E., Dembowski, K., Hooftman, L. & Bonig, H., Jan 3 2017, In: Journal of Translational Medicine. 15, 1, 2.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

2016

Targeting CD123 in acute myeloid leukemia using a T-cCell-Directed dual-Affinity retargeting platform

Al-Hussaini, M., Rettig, M. P., Ritchey, J. K., Karpova, D., Uy, G. L., Eissenberg, L. G., Gao, F., Eades, W. C., Bonvini, E., Chichili, G. R., Moore, P. A., Johnson, S., Collins, L. & Dipersio, J. F., Jan 7 2016, In: Blood. 127, 1, p. 122-131 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

126 Scopus citations

2015

Automated CD34+ cell isolation of peripheral blood stem cell apheresis product

Spohn, G., Wiercinska, E., Karpova, D., Bunos, M., Hümmer, C., Wingenfeld, E., Sorg, N., Poppe, C., Huppert, V., Stuth, J., Reck, K., Essl, M., Seifried, E. & Bönig, H., Oct 1 2015, In: Cytotherapy. 17, 10, p. 1465-1471 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Clinical-scale isolation of the total Aspergillus fumigatus-reactive T-helper cell repertoire for adoptive transfer

Bacher, P., Jochheim-Richter, A., Mockel-Tenbrink, N., Kniemeyer, O., Wingenfeld, E., Alex, R., Ortigao, A., Karpova, D., Lehrnbecher, T., Ullmann, A. J., Hamprecht, A., Cornely, O., Brakhage, A. A., Assenmacher, M., Bonig, H. & Scheffold, A., Oct 1 2015, In: Cytotherapy. 17, 10, p. 1396-1405 10 p.

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Concise Review: CXCR4/CXCL12 Signaling in Immature Hematopoiesis - Lessons from Pharmacological and Genetic Models

Karpova, D. & Bonig, H., Aug 1 2015, In: STEM CELLS. 33, 8, p. 2391-2399 9 p.

Research output: Contribution to journal › Review article › peer-review

67 Scopus citations

Functional consequences of perturbed CXCL12 signal processing: Analyses of immature hematopoiesis in GRK6-deficient mice

Chudziak, D., Spohn, G., Karpova, D., Dauber, K., Wiercinska, E., Miettinen, J. A., Papayannopoulou, T. & Bönig, H., Mar 15 2015, In: Stem Cells and Development. 24, 6, p. 737-746 10 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Variant rs1801157 in the 3' UTR of SDF-1β does not explain variability of healthy-donor G-CSF responsiveness

Schulz, M., Karpova, D., Schulz, M., Damert, A., Seifried, E., Vera, B. & Bönig, H., Mar 24 2015, In: PloS one. 10, 3, e0121859.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

2014

Effects of storage temperature on hematopoietic stability and microbial safety of BM aspirates

Hahn, S., Sireis, W., Hourfar, K., Karpova, D., Dauber, K., Kempf, V. A. J., Seifried, E., Schmidt, M. & Bonig, H., Mar 2014, In: Bone Marrow Transplantation. 49, 3, p. 338-348 11 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Extracellular Vesicle-Mediated Transfer of Genetic Information between the Hematopoietic System and the Brain in Response to Inflammation

Ridder, K., Keller, S., Dams, M., Rupp, A. K., Schlaudraff, J., Del Turco, D., Starmann, J., Macas, J., Karpova, D., Devraj, K., Depboylu, C., Landfried, B., Arnold, B., Plate, K. H., Höglinger, G., Sültmann, H., Altevogt, P. & Momma, S., 2014, In: PLoS biology. 12, 6, e1001874.

Research output: Contribution to journal › Article › peer-review

Open Access

271 Scopus citations

2013

The novel CXCR4 antagonist POL5551 mobilizes hematopoietic stem and progenitor cells with greater efficiency than Plerixafor

Karpova, D., Dauber, K., Spohn, G., Chudziak, D., Wiercinska, E., Schulz, M., Pettit, A. R., Levesque, J. P., Romagnoli, B., Patel, K., Chevalier, E., Dembowsky, K. & Bonig, H., Dec 2013, In: Leukemia. 27, 12, p. 2322-2331 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

2012

Functional characterization of protein variants of the human multidrug transporter ABCC2 by a novel targeted expression system in fibrosarcoma cells

Arlanov, R., Porter, A., Strand, D., Brough, R., Karpova, D., Kerb, R., Wojnowski, L., Schwab, M. & Lang, T., Apr 2012, In: Human mutation. 33, 4, p. 750-762 13 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Darja Karpova

Research output

Search results