• 537 Citations

Research output per year

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Personal profile

Research interests

My laboratory examines the relationship between viral oncogenesis and host immunity using unprecedented applications of molecular imaging of novel transgenic mouse models of human cancers. Tumors arise in complex microenvironments including stromal cells and immune mediators with cross talk among signaling pathways, cytokines, chemokines, and blood vessels. While the cancer promoting elements within the tumor microenvironment are valuable therapeutic targets, their characterization requires the interrogation of tumor-host interactions in immune competent animal models. The Tax oncogene carried by the Human T-cell Leukemia Virus promotes inflammation and tumorigenesis in vivo. My postdoctoral work included development of transgenic mouse strains and utilization of small molecules designed to produce bioluminescence in response to Tax expression. We used non-invasive bioluminescent imaging to identify inflammatory lesions that preceded spontaneous tumorigenesis by independently monitoring inflammation and oncogene expression in vivo. We are currently examining pathways of inflammation and oncogenesis and translational approaches in i) prostate carcinoma, ii) osteosarcoma, and iii) leukemia / lymphoma.

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Research Output

  • 537 Citations
  • 16 Article
  • 1 Letter
  • 1 Review article

Interferon regulatory factor 4 as a therapeutic target in adult T-cell leukemia lymphoma

Rauch, D. A., Olson, S. L., Harding, J. C., Sundaramoorthi, H., Kim, Y., Zhou, T., MacLeod, A. R., Challen, G. & Ratner, L., Aug 28 2020, In : Retrovirology. 17, 1, p. 27 1 p.

Research output: Contribution to journalArticle

Open Access
  • HTLV-1 viral oncogene HBZ drives bone destruction in adult T cell leukemia

    Xiang, J., Rauch, D. A., Huey, D. D., Panfil, A. R., Cheng, X., Esser, A. K., Su, X., Harding, J. C., Xu, Y., Fox, G. C., Fontana, F., Kobayashi, T., Su, J., Sundaramoorthi, H., Wong, W. H., Jia, Y., Rosol, T. J., Veis, D. J., Green, P. L., Niewiesk, S. & 2 others, Ratner, L. & Weilbaecher, K. N., 2019, In : JCI Insight. 4, 19, e128713.

    Research output: Contribution to journalArticle

  • Rapid progression of adult T-cell leukemia/lymphoma as tumor-infiltrating Tregs after PD-1 blockade

    Rauch, D. A., Conlon, K. C., Janakiram, M., Brammer, J. E., Harding, J. C., Ye, B. H., Zang, X., Ren, X., Olson, S., Cheng, X., Miljkovic, M. D., Sundaramoorthi, H., Joseph, A., Skidmore, Z. L., Griffith, O., Griffith, M., Waldmann, T. A. & Ratner, L., Oct 24 2019, In : Blood. 134, 17, p. 1406-1414 9 p.

    Research output: Contribution to journalArticle

  • 17 Scopus citations

    An activating mutation of interferon regulatory factor 4 (IRF4) in adult T-cell leukemia

    Cherian, M. A., Olson, S., Sundaramoorthi, H., Cates, K., Cheng, X., Harding, J., Martens, A., Challen, G. A., Tyagi, M., Ratner, L. & Rauch, D., May 4 2018, In : Journal of Biological Chemistry. 293, 18, p. 6844-6858 15 p.

    Research output: Contribution to journalArticle

  • 7 Scopus citations

    HTLV-1 viral oncogene HBZ induces osteolytic bone disease in transgenic mice

    Esser, A. K., Rauch, D. A., Xiang, J., Harding, J. C., Kohart, N. A., Ross, M. H., Su, X., Wu, K., Huey, D., Xu, Y., Vij, K., Green, P. L., Rosol, T. J., Niewiesk, S., Ratner, L. & Weilbaecher, K. N., 2017, In : Oncotarget. 8, 41, p. 69250-69263 14 p.

    Research output: Contribution to journalArticle

    Open Access
  • 6 Scopus citations