The Link laboratory studies mechanisms that regulate normal and malignant hematopoiesis, with a long-term goal of improving care for patients with hematopoietic disorders. Current research is focused on three general areas: 1) characterizing the regulation of hematopoietic niches in the bone marrow under homeostatic and stress conditions; 2) defining the molecular pathogenesis and developing new therapies for acute leukemia; and 3) defining the molecular pathogenesis and developing new therapies for congenital neutropenia. Cutting edge genomic, transgenic, and imaging approaches are being used in this research.

• Lab Website

Bone marrow transplant, G-CSF receptor, congenital neutropenia, molecular mechanisms controlling hematopoietic cell proliferation; differentiation; and migration, granulocyte colony stimulating factor receptor signal transduction and biological activities, hematology, oncology, leukemia

• Information for Patients

The Link laboratory emphasizes a collaborative, diverse, and inclusive research environment that places a priority on the career development of its trainees. I employ an individualized mentoring approach that is tailored to the trainees research experience and aptitude. I provide as many opportunities as possible for my trainees to pursue their scientific and professional goals, whatever they may be. I am the recipient of several awards for mentoring at Washington University.