Research output per year
Research output per year
Personal profile
Research interests
Our research is focused on three areas. 1) Leukemogenesis with an emphasis on leukemic stem cells. 2) Neutrophil biology with an emphasis on neutrophil development and trafficking. 3) Angiogenesis with an emphasis on the role of endothelial progenitors and their stimulation of post-natal angiogenesis. We have a translantional trial in which we are testing the hypothesis that mobilization of endothelial progenitors will improve blood flow in patients with critical limb ischemia secondary to peripheral vascular disease.
Areas of Clinical Interest
Bone marrow transplant, G-CSF receptor, congenital neutropenia, molecular mechanisms controlling hematopoietic cell proliferation; differentiation; and migration, granulocyte colony stimulating factor receptor signal transduction and biological activities, hematology, oncology, leukemia
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Genome sequencing as an alternative to cytogenetic analysis in myeloid cancers
Duncavage, E. J., Schroeder, M. C., O'Laughlin, M., Wilson, R., MacMillan, S., Bohannon, A., Kruchowski, S., Garza, J., Du, F., Hughes, A. E. O., Robinson, J., Hughes, E., Heath, S. E., Baty, J. D., Neidich, J., Christopher, M. J., Jacoby, M. A., Uy, G. L., Fulton, R. S., Miller, C. A. & 7 others, , Mar 11 2021, In: New England Journal of Medicine. 384, 10, p. 924-935 12 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
TLR7/8 agonist treatment induces an increase in bone marrow resident dendritic cells and hematopoietic progenitor expansion and mobilization
Li, S., Yao, J. C., Li, J. T., Schmidt, A. P. & Link, D. C., Apr 2021, In: Experimental Hematology. 96, p. 35-43.e7Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Author Correction: Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway (Nature Communications, (2019), 10, 1, (5649), 10.1038/s41467-019-13542-2)
Chen, S., Wang, Q., Yu, H., Capitano, M. L., Vemula, S., Nabinger, S. C., Gao, R., Yao, C., Kobayashi, M., Geng, Z., Fahey, A., Henley, D., Liu, S. Z., Barajas, S., Cai, W., Wolf, E. R., Ramdas, B., Cai, Z., Gao, H., Luo, N. & 12 others, , Dec 1 2020, In: Nature communications. 11, 1, 3856.Research output: Contribution to journal › Comment/debate
Open Access -
A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration
Matsushita, Y., Nagata, M., Kozloff, K. M., Welch, J. D., Mizuhashi, K., Tokavanich, N., Hallett, S. A., Link, D. C., Nagasawa, T., Ono, W. & Ono, N., Dec 1 2020, In: Nature communications. 11, 1, 332.Research output: Contribution to journal › Article › peer-review
Open Access49 Scopus citations -
Canonical signaling by TGF family members in mesenchymal stromal cells is dispensable for hematopoietic niche maintenance under basal and stress conditions
Krambs, J. R., Ezzi, G. A., Yao, J. C. & Link, D. C., May 2020, In: PloS one. 15, 5, e0233751.Research output: Contribution to journal › Article › peer-review
Open Access