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Daniel Link

Alan A and Edith L Wolff Distinguished Professor of Medicine, Professor of Pathology and Immunology

    • 21902 Citations
    1991 …2020

    Research output per year

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    Personal profile

    Research interests

    Our research is focused on three areas. 1) Leukemogenesis with an emphasis on leukemic stem cells. 2) Neutrophil biology with an emphasis on neutrophil development and trafficking. 3) Angiogenesis with an emphasis on the role of endothelial progenitors and their stimulation of post-natal angiogenesis. We have a translantional trial in which we are testing the hypothesis that mobilization of endothelial progenitors will improve blood flow in patients with critical limb ischemia secondary to peripheral vascular disease.

    Areas of Clinical Interest

    Bone marrow transplant, G-CSF receptor, congenital neutropenia, molecular mechanisms controlling hematopoietic cell proliferation; differentiation; and migration, granulocyte colony stimulating factor receptor signal transduction and biological activities, hematology, oncology, leukemia

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    Research Output

    Author Correction: Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway (Nature Communications, (2019), 10, 1, (5649), 10.1038/s41467-019-13542-2)

    Chen, S., Wang, Q., Yu, H., Capitano, M. L., Vemula, S., Nabinger, S. C., Gao, R., Yao, C., Kobayashi, M., Geng, Z., Fahey, A., Henley, D., Liu, S. Z., Barajas, S., Cai, W., Wolf, E. R., Ramdas, B., Cai, Z., Gao, H., Luo, N. & 12 others, Sun, Y., Wong, T. N., Link, D. C., Liu, Y., Boswell, H. S., Mayo, L. D., Huang, G., Kapur, R., Yoder, M. C., Broxmeyer, H. E., Gao, Z. & Liu, Y., Dec 1 2020, In : Nature communications. 11, 1, 3856.

    Research output: Contribution to journal › Comment/debate

    Open Access

    • A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration

    Matsushita, Y., Nagata, M., Kozloff, K. M., Welch, J. D., Mizuhashi, K., Tokavanich, N., Hallett, S. A., Link, D. C., Nagasawa, T., Ono, W. & Ono, N., Dec 1 2020, In : Nature communications. 11, 1, 332.

    Research output: Contribution to journal › Article

    Open Access
    • 11 Scopus citations

    Canonical signaling by TGF family members in mesenchymal stromal cells is dispensable for hematopoietic niche maintenance under basal and stress conditions

    Krambs, J. R., Ezzi, G. A., Yao, J. C. & Link, D. C., May 2020, In : PloS one. 15, 5, e0233751.

    Research output: Contribution to journal › Article

    Open Access

    • Cooperating, congenital neutropenia–associated Csf3r and Runx1 mutations activate pro-inflammatory signaling and inhibit myeloid differentiation of mouse HSPCs

    Ritter, M., Klimiankou, M., Klimenkova, O., Schambach, A., Hoffmann, D., Schmidt, A., Kanz, L., Link, D. C., Welte, K. & Skokowa, J., Oct 1 2020, In : Annals of Hematology. 99, 10, p. 2329-2338 10 p.

    Research output: Contribution to journal › Article

    Open Access

    • Radiation causes tissue damage by dysregulating inflammasome–gasdermin D signaling in both host and transplanted cells

    Xiao, J., Wang, C., Yao, J. C., Alippe, Y., Yang, T., Kress, D., Sun, K., Kostecki, K. L., Monahan, J. B., Veis, D. J., AbuAmer, Y., Link, D. C. & Mbalaviele, G., Aug 6 2020, In : PLoS biology. 18, 8, e3000807.

    Research output: Contribution to journal › Article

    Open Access