Research output per year
Research output per year
Personal profile
Research interests
Our research is focused on three areas. 1) Leukemogenesis with an emphasis on leukemic stem cells. 2) Neutrophil biology with an emphasis on neutrophil development and trafficking. 3) Angiogenesis with an emphasis on the role of endothelial progenitors and their stimulation of post-natal angiogenesis. We have a translantional trial in which we are testing the hypothesis that mobilization of endothelial progenitors will improve blood flow in patients with critical limb ischemia secondary to peripheral vascular disease.
Areas of Clinical Interest
Bone marrow transplant, G-CSF receptor, congenital neutropenia, molecular mechanisms controlling hematopoietic cell proliferation; differentiation; and migration, granulocyte colony stimulating factor receptor signal transduction and biological activities, hematology, oncology, leukemia
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Research output
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Author Correction: Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway (Nature Communications, (2019), 10, 1, (5649), 10.1038/s41467-019-13542-2)
Chen, S., Wang, Q., Yu, H., Capitano, M. L., Vemula, S., Nabinger, S. C., Gao, R., Yao, C., Kobayashi, M., Geng, Z., Fahey, A., Henley, D., Liu, S. Z., Barajas, S., Cai, W., Wolf, E. R., Ramdas, B., Cai, Z., Gao, H., Luo, N. & 12 others, , Dec 1 2020, In: Nature communications. 11, 1, 3856.Research output: Contribution to journal › Comment/debate
Open Access -
A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration
Matsushita, Y., Nagata, M., Kozloff, K. M., Welch, J. D., Mizuhashi, K., Tokavanich, N., Hallett, S. A., Link, D. C., Nagasawa, T., Ono, W. & Ono, N., Dec 1 2020, In: Nature communications. 11, 1, 332.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
Canonical signaling by TGF family members in mesenchymal stromal cells is dispensable for hematopoietic niche maintenance under basal and stress conditions
Krambs, J. R., Ezzi, G. A., Yao, J. C. & Link, D. C., May 2020, In: PloS one. 15, 5, e0233751.Research output: Contribution to journal › Article › peer-review
Open Access -
Clonal hematopoiesis and risk for hematologic malignancy
Warren, J. T. & Link, D. C., Oct 1 2020, In: Blood. 136, 14, p. 1599-1605 7 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Cooperating, congenital neutropenia–associated Csf3r and Runx1 mutations activate pro-inflammatory signaling and inhibit myeloid differentiation of mouse HSPCs
Ritter, M., Klimiankou, M., Klimenkova, O., Schambach, A., Hoffmann, D., Schmidt, A., Kanz, L., Link, D. C., Welte, K. & Skokowa, J., Oct 1 2020, In: Annals of Hematology. 99, 10, p. 2329-2338 10 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations