• 5166 Citations

Research output per year

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Personal profile

Research interests

My research is focused on pre-clinical studies and early phase clinical trials evaluating molecular therapeutic agents, including IGF-IR antibody and Chk1 inhibitors, for the treatment of breast cancer. Breast cancer cell lines and xenograft models as well as patients’ specimens are used to evaluate the mechanisms of action of these agents and to develop potential predictors of treatment response. A multi-center phase I/II study of IMC-A12 (ImClone Inc.), an IGF-IR antibody, in combination with temsirolimus in patients with metastatic breast cancer has been approved by NCI/CTEP to evaluate the efficacy and tolerability for the combined targeting of IGF-IR and mTOR. In collaboration with Drs. Helen Piwnica-Worms and Paula Fracasso, we are conducting an exploratory study of UCN-01, a Chk1 inhibitor, in combination with irinotecan in patients with triple negative breast cancer (negative for estrogen receptor, progesterone receptor and HER2 overexpression).

Areas of Clinical Interest

Cancer, breast cancer

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Research Output

Cisplatin-associated neuropathy characteristics compared with those associated with other neurotoxic chemotherapy agents (Alliance A151724)

Albany, C., Dockter, T., Wolfe, E., Le-Rademacher, J., Wagner-Johnston, N., Einhorn, L., Lafky, J. M., Smith, E., Pachman, D., Staff, N., Ma, C., Loprinzi, C. L. & Costello, B. A., Jan 1 2020, (Accepted/In press) In : Supportive Care in Cancer.

Research output: Contribution to journalArticle

  • Evidence-based guidelines for managing patients with primary ER+ HER2− breast cancer deferred from surgery due to the COVID-19 pandemic

    Dowsett, M., Ellis, M. J., Dixon, J. M., Gluz, O., Robertson, J., Kates, R., Suman, V. J., Turnbull, A. K., Nitz, U., Christgen, M., Kreipe, H., Kuemmel, S., Bliss, J. M., Barry, P., Johnston, S. R., Jacobs, S. A., Ma, C. X., Smith, I. E. & Harbeck, N., Dec 1 2020, In : npj Breast Cancer. 6, 1, 21.

    Research output: Contribution to journalArticle

    Open Access
  • Microscaled proteogenomic methods for precision oncology

    Satpathy, S., Jaehnig, E. J., Krug, K., Kim, B. J., Saltzman, A. B., Chan, D. W., Holloway, K. R., Anurag, M., Huang, C., Singh, P., Gao, A., Namai, N., Dou, Y., Wen, B., Vasaikar, S. V., Mutch, D., Watson, M. A., Ma, C., Ademuyiwa, F. O., Rimawi, M. F. & 13 others, Schiff, R., Hoog, J., Jacobs, S., Malovannaya, A., Hyslop, T., Clauser, K. R., Mani, D. R., Perou, C. M., Miles, G., Zhang, B., Gillette, M. A., Carr, S. A. & Ellis, M. J., Dec 1 2020, In : Nature communications. 11, 1, 532.

    Research output: Contribution to journalArticle

    Open Access
  • 9 Scopus citations
    Open Access
  • 2 Scopus citations
  • 1 Scopus citations