• 1934 Citations

Research output per year

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Personal profile

Research interests

Stem cells constitute an essential reservoir of renewal potential conserved during evolution. The defining properties of self-renewal and multipotency make stem cells ideally suited for a central role in the generation of new cells during the lifetime of an organism. Our laboratory investigates the basis of stem cell behavior in their native tissue microenvironments. We use the powerful molecular, genetic and cell lineage tracing methodologies available only in the fruit fly, Drosophila melanogaster, to dissect the mechanisms controlling stem cell activity during the processes of development, regeneration and disease. In this way, we hope to define the core principles and regulatory circuitry that govern stem cell behavior. Such advances may ultimately translate into novel regenerative medicine therapies.

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Research Output

  • 1934 Citations
  • 17 Article
  • 2 Review article
  • 1 Comment/debate

Ultra-low frequency labeling of single cell lineages in Drosophila

Snee, M., Lee, W. C., Beehler-Evans, R. & Micchelli, C. A., Jan 1 2020, In : Developmental Biology. 457, 1, p. 9-12 4 p.

Research output: Contribution to journalArticle

  • LysMD3 is a type II membrane protein without an in vivo role in the response to a range of pathogens

    Yokoyama, C. C., Baldridge, M., Leung, D., Zhao, G., Desai, C., Liu, T-C., Diaz-Ochoa, V. E., Huynh, J. P., Kimmey, J. M., Sennott, E. L., Hole, C. R., Idol, R. A., Park, S., Storek, K. M., Wang, C., Hwang, S., Milam, A. V., Chen, E., Kerrinnes, T., Starnbach, M. N. & 12 others, Handley, S., Mysorekar, I., Allen, P., Monack, D. M., Dinauer, M., Brent, T., Tsolis, R. M., Dworkin, J. E., Stallings, C., Amarasinghe, G., Micchelli, C. & Virgina, H. W., Apr 20 2018, In : Journal of Biological Chemistry. 293, 16, p. 6022-6038 17 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Generation of enteroendocrine cell diversity in midgut stem cell lineages

    Beehler-Evans, R. & Micchelli, C. A., Feb 15 2015, In : Development (Cambridge). 142, 4, p. 654-664 11 p.

    Research output: Contribution to journalArticle

    Open Access
  • 47 Scopus citations
    Open Access
  • 10 Scopus citations

    Whole-mount immunostaining of the adult Drosophila gastrointestinal tract

    Micchelli, C. A., Jun 15 2014, In : Methods. 68, 1, p. 273-279 7 p.

    Research output: Contribution to journalArticle

  • 6 Scopus citations