• 2232
    Citations
19962020

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Research interests

Stem cells constitute an essential reservoir of renewal potential conserved during evolution. The defining properties of self-renewal and multipotency make stem cells ideally suited for a central role in the generation of new cells during the lifetime of an organism. Our laboratory investigates the basis of stem cell behavior in their native tissue microenvironments. We use the powerful molecular, genetic and cell lineage tracing methodologies available only in the fruit fly, Drosophila melanogaster, to dissect the mechanisms controlling stem cell activity during the processes of development, regeneration and disease. In this way, we hope to define the core principles and regulatory circuitry that govern stem cell behavior. Such advances may ultimately translate into novel regenerative medicine therapies.

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