Cornelius von Morze

2022

Multi-band echo-planar spectroscopic imaging of hyperpolarized ¹³C probes in a compact preclinical PET/MR scanner

von Morze, C., Blazey, T., Baeza, R., Garipov, R., Whitehead, T., Reed, G. D., Garbow, J. R. & Shoghi, K. I., May 2022, In: Magnetic resonance in medicine. 87, 5, p. 2120-2129 10 p.

Research output: Contribution to journal › Article › peer-review

Whole-Abdomen Metabolic Imaging of Healthy Volunteers Using Hyperpolarized [1-¹³C]pyruvate MRI

Lee, P. M., Chen, H. Y., Gordon, J. W., Wang, Z. J., Bok, R., Hashoian, R., Kim, Y., Liu, X., Nickles, T., Cheung, K., Alas, F. D. L., Daniel, H., Larson, P. E. Z., von Morze, C., Vigneron, D. B. & Ohliger, M. A., 2022, (Accepted/In press) In: Journal of Magnetic Resonance Imaging.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

2021

¹⁵N-carnitine, a novel endogenous hyperpolarized MRI probe with long signal lifetime

von Morze, C., Engelbach, J. A., Reed, G. D., Chen, A. P., Quirk, J. D., Blazey, T., Mahar, R., Malloy, C. R., Garbow, J. R. & Merritt, M. E., Apr 2021, In: Magnetic resonance in medicine. 85, 4, p. 1814-1820 7 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

⁵⁵Mn-based fiducial markers for rapid and automated RF coil localization for hyperpolarized ¹³C MRI

Ohliger, M. A., Gordon, J. W., Carvajal, L., Larson, P. E. Z., Ou, J. J., Agarwal, S., Zhu, Z., Vigneron, D. B. & von Morze, C., Jan 1 2021, In: Magnetic resonance in medicine. 85, 1, p. 518-530 13 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Analysis methods for hyperpolarized carbon (¹³C) MRI of the Kidney

Reed, G. D., Korn, N. J., Laustsen, C. & von Morze, C., 2021, Methods in Molecular Biology. Humana Press Inc., p. 697-710 14 p. (Methods in Molecular Biology; vol. 2216).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Open Access

Comparison of hyperpolarized ¹³C and non-hyperpolarized deuterium MRI approaches for imaging cerebral glucose metabolism at 4.7 T

von Morze, C., Engelbach, J. A., Blazey, T., Quirk, J. D., Reed, G. D., Ippolito, J. E. & Garbow, J. R., Apr 2021, In: Magnetic resonance in medicine. 85, 4, p. 1795-1804 10 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Hyperpolarized carbon (¹³C) MRI of the Kidney: Experimental Protocol

Laustsen, C., von Morze, C. & Reed, G. D., 2021, Methods in Molecular Biology. Humana Press Inc., p. 481-493 13 p. (Methods in Molecular Biology; vol. 2216).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Open Access

Hyperpolarized carbon (¹³C) MRI of the Kidneys: Basic Concept

von Morze, C., Reed, G. D., Wang, Z. J., Ohliger, M. A. & Laustsen, C., 2021, Methods in Molecular Biology. Humana Press Inc., p. 267-278 12 p. (Methods in Molecular Biology; vol. 2216).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Open Access

Metabolite-specific echo-planar imaging of hyperpolarized [1-¹³ c]pyruvate at 4.7 t

Blazey, T., Reed, G. D., Garbow, J. R. & von Morze, C., Sep 2021, In: Tomography (Ann Arbor, Mich.). 7, 3, p. 466-476 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Simultaneous T₁ and T₂ mapping of hyperpolarized ¹³C compounds using the bSSFP sequence

Milshteyn, E., Reed, G. D., Gordon, J. W., von Morze, C., Cao, P., Tang, S., Leynes, A. P., Larson, P. E. Z. & Vigneron, D. B., Mar 2020, In: Journal of Magnetic Resonance. 312, 106691.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

2019

Cancer in the crosshairs: targeting cancer metabolism with hyperpolarized carbon-13 MRI technology

von Morze, C. & Merritt, M. E., Oct 1 2019, In: NMR in biomedicine. 32, 10, e3937.

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Pulse sequence considerations for quantification of pyruvate-to-lactate conversion k_PL in hyperpolarized ¹³C imaging

Chen, H. Y., Gordon, J. W., Bok, R. A., Cao, P., von Morze, C., van Criekinge, M., Milshteyn, E., Carvajal, L., Hurd, R. E., Kurhanewicz, J., Vigneron, D. B. & Larson, P. E. Z., Mar 1 2019, In: NMR in biomedicine. 32, 3, e4052.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

2018

Detecting liver injury non-invasively using hyperpolarized ¹³C MRI

von Morze, C., Jun 2018, In: Liver International. 38, 6, p. 988-990 3 p.

Research output: Contribution to journal › Editorial

Open Access

1 Scopus citations

Direct assessment of renal mitochondrial redox state using hyperpolarized ¹³C-acetoacetate

von Morze, C., Ohliger, M. A., Marco-Rius, I., Wilson, D. M., Flavell, R. R., Pearce, D., Vigneron, D. B., Kurhanewicz, J. & Wang, Z. J., Apr 2018, In: Magnetic resonance in medicine. 79, 4, p. 1862-1869 8 p.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

High spatiotemporal resolution bSSFP imaging of hyperpolarized [1-¹³C]pyruvate and [1-¹³C]lactate with spectral suppression of alanine and pyruvate-hydrate

Milshteyn, E., von Morze, C., Gordon, J. W., Zhu, Z., Larson, P. E. Z. & Vigneron, D. B., Sep 2018, In: Magnetic resonance in medicine. 80, 3, p. 1048-1060 13 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Imaging glutathione depletion in the rat brain using ascorbate-derived hyperpolarized MR and PET probes

Qin, H., Carroll, V. N., Sriram, R., Villanueva-Meyer, J. E., Von Morze, C., Wang, Z. J., Mutch, C. A., Keshari, K. R., Flavell, R. R., Kurhanewicz, J. & Wilson, D. M., Dec 1 2018, In: Scientific reports. 8, 1, 7928.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

In vivo hyperpolarization transfer in a clinical MRI scanner

von Morze, C., Reed, G. D., Larson, P. E., Mammoli, D., Chen, A. P., Tropp, J., Van Criekinge, M., Ohliger, M. A., Kurhanewicz, J., Vigneron, D. B. & Merritt, M. E., Aug 2018, In: Magnetic resonance in medicine. 80, 2, p. 480-487 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Late-stage deuteration of ¹³C-enriched substrates for: T ₁ prolongation in hyperpolarized ¹³C MRI

Taglang, C., Korenchan, D. E., Von Morze, C., Yu, J., Najac, C., Wang, S., Blecha, J. E., Subramaniam, S., Bok, R., Vanbrocklin, H. F., Vigneron, D. B., Ronen, S. M., Sriram, R., Kurhanewicz, J., Wilson, D. M. & Flavell, R. R., 2018, In: Chemical Communications. 54, 41, p. 5233-5236 4 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Non-invasive detection of divergent metabolic signals in insulin deficiency vs. insulin resistance in vivo

Morze, C. V., Allu, P. K. R., Chang, G. Y., Marco-Rius, I., Milshteyn, E., Wang, Z. J., Ohliger, M. A., Gleason, C. E., Kurhanewicz, J., Vigneron, D. B. & Pearce, D., Dec 1 2018, In: Scientific reports. 8, 1, 2088.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Sensitivity enhancement for detection of hyperpolarized ¹³C MRI probes with ¹H spin coupling introduced by enzymatic transformation in vivo

von Morze, C., Tropp, J., Chen, A. P., Marco-Rius, I., Van Criekinge, M., Skloss, T. W., Mammoli, D., Kurhanewicz, J., Vigneron, D. B., Ohliger, M. A. & Merritt, M. E., Jul 2018, In: Magnetic resonance in medicine. 80, 1, p. 36-41 6 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Using a local low rank plus sparse reconstruction to accelerate dynamic hyperpolarized ¹³C imaging using the bSSFP sequence

Milshteyn, E., von Morze, C., Reed, G. D., Shang, H., Shin, P. J., Larson, P. E. Z. & Vigneron, D. B., May 2018, In: Journal of Magnetic Resonance. 290, p. 46-59 14 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

2017

Assessing prostate cancer aggressiveness with hyperpolarized dual-agent 3D dynamic imaging of metabolism and perfusion

Chen, H. Y., Larson, P. E. Z., Bok, R. A., Von Morze, C., Sriram, R., Santos, R. D., Santos, J. D., Gordon, J. W., Bahrami, N., Ferrone, M., Kurhanewicz, J. & Vigneron, D. B., Jun 15 2017, In: Cancer research. 77, 12, p. 3207-3216 10 p.

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Combining hyperpolarized ¹³C MRI with a liver-specific gadolinium contrast agent for selective assessment of hepatocyte metabolism

Ohliger, M. A., von Morze, C., Marco-Rius, I., Gordon, J., Larson, P. E. Z., Bok, R., Chen, H. Y., Kurhanewicz, J. & Vigneron, D., Jun 2017, In: Magnetic resonance in medicine. 77, 6, p. 2356-2363 8 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Detection of localized changes in the metabolism of hyperpolarized gluconeogenic precursors ¹³C-lactate and ¹³C-pyruvate in kidney and liver

von Morze, C., Chang, G. Y., Larson, P. E. Z., Shang, H., Allu, P. K. R., Bok, R. A., Crane, J. C., Olson, M. P., Tan, C. T., Marco-Rius, I., Nelson, S. J., Kurhanewicz, J., Pearce, D. & Vigneron, D. B., Apr 1 2017, In: Magnetic resonance in medicine. 77, 4, p. 1429-1437 9 p.

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Development of high resolution 3D hyperpolarized carbon-13 MR molecular imaging techniques

Milshteyn, E., von Morze, C., Reed, G. D., Shang, H., Shin, P. J., Zhu, Z., Chen, H. Y., Bok, R., Goga, A., Kurhanewicz, J., Larson, P. E. Z. & Vigneron, D. B., May 1 2017, In: Magnetic Resonance Imaging. 38, p. 152-162 11 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Dicarboxylic acids as pH sensors for hyperpolarized ¹³C magnetic resonance spectroscopic imaging

Korenchan, D. E., Taglang, C., Von Morze, C., Blecha, J. E., Gordon, J. W., Sriram, R., Larson, P. E. Z., Vigneron, D. B., Vanbrocklin, H. F., Kurhanewicz, J., Wilson, D. M. & Flavell, R. R., May 7 2017, In: Analyst. 142, 9, p. 1429-1433 5 p.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Hyperpolarized ¹³C magnetic resonance evaluation of renal ischemia reperfusion injury in a murine model

Baligand, C., Qin, H., True-Yasaki, A., Gordon, J. W., von Morze, C., Santos, J. D., Wilson, D. M., Raffai, R., Cowley, P. M., Baker, A. J., Kurhanewicz, J., Lovett, D. H. & Wang, Z. J., Oct 2017, In: NMR in biomedicine. 30, 10, e3765.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Hyperpolarized ¹³C spectroscopic evaluation of oxidative stress in a rodent model of steatohepatitis

Wilson, D. M., Di Gialleonardo, V., Wang, Z. J., Carroll, V., Von Morze, C., Taylor, A., Sai, V., VanCriekinge, M., Bok, R., Ohliger, M. A. & Keshari, K. R., 2017, In: Scientific reports. 7, 46014.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Investigating tumor perfusion by hyperpolarized ¹³C MRI with comparison to conventional gadolinium contrast-enhanced MRI and pathology in orthotopic human GBM xenografts

Park, I., von Morze, C., Lupo, J. M., Ardenkjaer-Larsen, J. H., Kadambi, A., Vigneron, D. B. & Nelson, S. J., Feb 1 2017, In: Magnetic resonance in medicine. 77, 2, p. 841-847 7 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Monitoring acute metabolic changes in the liver and kidneys induced by fructose and glucose using hyperpolarized [2-¹³C]dihydroxyacetone

Marco-Rius, I., von Morze, C., Sriram, R., Cao, P., Chang, G. Y., Milshteyn, E., Bok, R. A., Ohliger, M. A., Pearce, D., Kurhanewicz, J., Larson, P. E. Z., Vigneron, D. B. & Merritt, M., Jan 1 2017, In: Magnetic resonance in medicine. 77, 1, p. 65-73 9 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Multiband spectral-spatial RF excitation for hyperpolarized [2-¹³C]dihydroxyacetone ¹³C-MR metabolism studies

Marco-Rius, I., Cao, P., von Morze, C., Merritt, M., Moreno, K. X., Chang, G. Y., Ohliger, M. A., Pearce, D., Kurhanewicz, J., Larson, P. E. Z. & Vigneron, D. B., Apr 1 2017, In: Magnetic resonance in medicine. 77, 4, p. 1419-1428 10 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Spectrally selective three-dimensional dynamic balanced steady-state free precession for hyperpolarized C-13 metabolic imaging with spectrally selective radiofrequency pulses

Shang, H., Sukumar, S., von Morze, C., Bok, R. A., Marco-Rius, I., Kerr, A., Reed, G. D., Milshteyn, E., Ohliger, M. A., Kurhanewicz, J., Larson, P. E. Z., Pauly, J. M. & Vigneron, D. B., Sep 2017, In: Magnetic resonance in medicine. 78, 3, p. 963-975 13 p.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

2016

Development and testing of hyperpolarized ¹³C MR calibrationless parallel imaging

Feng, Y., Gordon, J. W., Shin, P. J., Von Morze, C., Lustig, M., Larson, P. E. Z., Ohliger, M. A., Carvajal, L., Tropp, J., Pauly, J. M. & Vigneron, D. B., Jan 2016, In: Journal of Magnetic Resonance. 262, p. 1-7 7 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Handheld electromagnet carrier for transfer of hyperpolarized carbon-13 samples

Shang, H., Skloss, T., Von Morze, C., Carvajal, L., Van Criekinge, M., Milshteyn, E., Larson, P. E. Z., Hurd, R. E. & Vigneron, D. B., Feb 1 2016, In: Magnetic resonance in medicine. 75, 2, p. 917-922 6 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

High spatiotemporal resolution hyperpolarized¹³ C angiography

Reed, G. D., von Morze, C., Addy, N. O., Ingle, R. R., Johnson, K. O., Overall, W. R., Hu, B. S., Vigneron, D. B., Larson, P. E. & Santos, J. M., 2016, In: Journal of Cardiovascular Magnetic Resonance. 18, p. 1-2 2 p., Q30.

Research output: Contribution to journal › Comment/debate

Open Access

3 Scopus citations

Hyperpolarized [¹³C]ketobutyrate, a molecular analog of pyruvate with modified specificity for LDH isoforms

Von Morze, C., Bok, R. A., Ohliger, M. A., Zhu, Z., Vigneron, D. B. & Kurhanewicz, J., May 1 2016, In: Magnetic resonance in medicine. 75, 5, p. 1894-1900 7 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

2015

Application of Good's buffers to pH imaging using hyperpolarized ¹³C MRI

Flavell, R. R., Von Morze, C., Blecha, J. E., Korenchan, D. E., Van Criekinge, M., Sriram, R., Gordon, J. W., Chen, H. Y., Subramaniam, S., Bok, R. A., Wang, Z. J., Vigneron, D. B., Larson, P. E., Kurhanewicz, J. & Wilson, D. M., Aug 3 2015, In: Chemical Communications. 51, 74, p. 14119-14122 4 p.

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

2014

Directly detected ⁵⁵Mn MRI: Application to phantoms for human hyperpolarized ¹³C MRI development

von Morze, C., Carvajal, L., Reed, G. D., Swisher, C. L., Tropp, J. & Vigneron, D. B., 2014, In: Magnetic Resonance Imaging. 32, 10, p. 1165-1170 6 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

High resolution ¹³C MRI with hyperpolarized urea: In vivo T ₂ mapping and ¹⁵N labeling effects

Reed, G. D., Von Morze, C., Bok, R., Koelsch, B. L., Van Criekinge, M., Smith, K. J., Shang, H., Larson, P. E. Z., Kurhanewicz, J. & Vigneron, D. B., Feb 2014, In: IEEE Transactions on Medical Imaging. 33, 2, p. 362-371 10 p., 6648454.

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Simultaneous multiagent hyperpolarized ¹³C perfusion imaging

Von Morze, C., Bok, R. A., Reed, G. D., Ardenkjaer-Larsen, J. H., Kurhanewicz, J. & Vigneron, D. B., Dec 1 2014, In: Magnetic resonance in medicine. 72, 6, p. 1599-1609 11 p.

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

2013

Frequency-specific SSFP for hyperpolarized ¹³C metabolic imaging at 14.1 T

von Morze, C., Sukumar, S., Reed, G. D., Larson, P. E. Z., Bok, R. A., Kurhanewicz, J. & Vigneron, D. B., Feb 2013, In: Magnetic Resonance Imaging. 31, 2, p. 163-170 8 p.

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Rapid sequential injections of hyperpolarized [1-¹³C]pyruvate in vivo using a sub-kelvin, multi-sample DNP polarizer

Hu, S., Larson, P. E. Z., VanCriekinge, M., Leach, A. M., Park, I., Leon, C., Zhou, J., Shin, P. J., Reed, G., Keselman, P., Von Morze, C., Yoshihara, H., Bok, R. A., Nelson, S. J., Kurhanewicz, J. & Vigneron, D. B., May 2013, In: Magnetic Resonance Imaging. 31, 4, p. 490-496 7 p.

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Super-resolution track density imaging of glioblastoma: Histopathologic correlation

Barajas, R. F., Hess, C. P., Phillips, J. J., Von Morze, C. J., Yu, J. P., Chang, S. M., Nelson, S. J., McDermott, M. W., Berger, M. S. & Cha, S., Jul 2013, In: American Journal of Neuroradiology. 34, 7, p. 1319-1325 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

WE‐C‐116‐02: High Resolution C‐13 MRI with Hyperpolarized [C‐13,N‐15] Urea

Reed, G., Von Morze, C., Bok, R., Koelsch, B., Smith, K., Van Criekinge, M., Larson, P., Kurhanewicz, J. & Vigneron, D., Jun 2013, In: Medical physics. 40, 6, 1 p.

Research output: Contribution to journal › Article › peer-review

2012

A method for simultaneous echo planar imaging of hyperpolarized ¹³C pyruvate and ¹³C lactate

Reed, G. D., Larson, P. E. Z., Morze, C. V., Bok, R., Lustig, M., Kerr, A. B., Pauly, J. M., Kurhanewicz, J. & Vigneron, D. B., Apr 2012, In: Journal of Magnetic Resonance. 217, p. 41-47 7 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Investigating tumor perfusion and metabolism using multiple hyperpolarized ¹³C compounds: HP001, pyruvate and urea

Von Morze, C., Larson, P. E. Z., Hu, S., Yoshihara, H. A. I., Bok, R. A., Goga, A., Ardenkjaer-Larsen, J. H. & Vigneron, D. B., Apr 2012, In: Magnetic Resonance Imaging. 30, 3, p. 305-311 7 p.

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Monitoring urea transport in rat kidney in vivo using hyperpolarized ¹³C magnetic resonance imaging

von Morze, C., Bok, R. A., Sands, J. M., Kurhanewicz, J. & Vigneron, D. B., 2012, In: American Journal of Physiology - Renal Physiology. 302, 12, p. F1658-F1662

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

2011

Imaging of blood flow using hyperpolarized [¹³C]urea in preclinical cancer models

Von Morze, C., Larson, P. E. Z., Hu, S., Keshari, K., Wilson, D. M., Ardenkjaer-Larsen, J. H., Goga, A., Bok, R., Kurhanewicz, J. & Vigneron, D. B., Mar 2011, In: Journal of Magnetic Resonance Imaging. 33, 3, p. 692-697 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

84 Scopus citations

In vivo measurement of normal rat intracellular pyruvate and lactate levels after injection of hyperpolarized [1- ¹³C]alanine

Hu, S., Zhu, M., Yoshihara, H. A. I., Wilson, D. M., Keshari, K. R., Shin, P., Reed, G., von Morze, C., Bok, R., Larson, P. E. Z., Kurhanewicz, J. & Vigneron, D. B., Oct 2011, In: Magnetic Resonance Imaging. 29, 8, p. 1035-1040 6 p.

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Multi-band frequency encoding method for metabolic imaging with hyperpolarized [1- ¹³C]pyruvate

Von Morze, C., Reed, G., Shin, P., Larson, P. E. Z., Hu, S., Bok, R. & Vigneron, D. B., Aug 2011, In: Journal of Magnetic Resonance. 211, 2, p. 109-113 5 p.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Cornelius von Morze

Research output

Search results