• 16020 Citations
1985 …2019
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Personal profile

Research interests

The broad context of our research is the molecular basis, and functional role, of potassium channels. The early cloning of channel genes led to understanding the molecular basis of function by mutagenic and now crystallographic methods. In parallel, these basic studies have fueled the genetic manipulation of channels in recombinant organisms, in turn explaining ion channel diseases and informing clinical therapies. Our own major contributions include (1) the cloning and expression of novel K channel genes, (2) elucidation of the mechanism of K (Kir) channel rectification, (3) elucidation of the molecular basis of KATP channel function, (4) the first molecular model of the Kir channel pore, (5) transgenic animal models of diabetes, hyperinsulinism, and cardiac dysrrhythmias. Current major challenges range from atomic resolution of Kir channel structure and function, to further elucidation of the roles of Kir channels in organ function and dysfunction in the heart, pancreas, vasculature and brain.

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  • 16 Similar Profiles
KATP Channels Medicine & Life Sciences
Adenosine Triphosphate Medicine & Life Sciences
Potassium Channels Medicine & Life Sciences
Inwardly Rectifying Potassium Channel Medicine & Life Sciences
Sulfonylurea Receptors Medicine & Life Sciences
Mutation Medicine & Life Sciences
Polyamines Medicine & Life Sciences
Insulin Medicine & Life Sciences

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Research Output 1985 2019

1 Citation (Scopus)

Beta-cell excitability and excitability-driven diabetes in adult Zebrafish islets

Emfinger, C. H., Lőrincz, R., Wang, Y., York, N. W., Singareddy, S. S., Ikle, J. M., Tryon, R. C., McClenaghan, C., Shyr, Z. A., Huang, Y., Reissaus, C. A., Meyer, D., Piston, D., Hyrc, K., Remedi, M. & Nichols, C., Jun 1 2019, In : Physiological Reports. 7, 11, e14101.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Zebrafish
Calcium
Glucose
Fishes
KATP Channels
1 Citation (Scopus)

Genetic Discovery of ATP-Sensitive K + Channels in Cardiovascular Diseases

Huang, Y., Hu, D., Huang, C. & Nichols, C., May 1 2019, In : Circulation. Arrhythmia and electrophysiology. 12, 5, p. e007322

Research output: Contribution to journalArticleResearchpeer-review

Cardiovascular Diseases
Adenosine Triphosphate
Sulfonylurea Receptors
Physiological Phenomena
KATP Channels

Glibenclamide treatment in a Cantú syndrome patient with a pathogenic ABCC9 gain-of-function variant: Initial experience

Ma, A., Gurnasinghani, S., Kirk, E. P., McClenaghan, C., Singh, G., Grange, D., Pandit, C., Zhu, Y., Roscioli, T., Elakis, G., Buckley, M., Mehta, B., Roberts, P., Mervis, J., Biggin, A. & Nichols, C., Aug 1 2019, In : American Journal of Medical Genetics, Part A. 179, 8, p. 1585-1590 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Glyburide
Pressure
Patent Ductus Arteriosus
Hypoglycemia
Newborn Infant
1 Citation (Scopus)

Potassium channel selectivity filter dynamics revealed by single-molecule FRET

Wang, S., Lee, S. J., Maksaev, G., Fang, X., Zuo, C. & Nichols, C., Apr 1 2019, In : Nature Chemical Biology. 15, 4, p. 377-383 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Potassium Channels
Ions
Cations
Permeability
Mutation

Pulmonary Hypertension and ATP-Sensitive Potassium Channels

McClenaghan, C., Woo, K. V. & Nichols, C., Jul 1 2019, In : Hypertension (Dallas, Tex. : 1979). 74, 1, p. 14-22 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
KATP Channels
Pulmonary Hypertension