• 16552 Citations
1985 …2020
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Personal profile

Research interests

The broad context of our research is the molecular basis, and functional role, of potassium channels. The early cloning of channel genes led to understanding the molecular basis of function by mutagenic and now crystallographic methods. In parallel, these basic studies have fueled the genetic manipulation of channels in recombinant organisms, in turn explaining ion channel diseases and informing clinical therapies. Our own major contributions include (1) the cloning and expression of novel K channel genes, (2) elucidation of the mechanism of K (Kir) channel rectification, (3) elucidation of the molecular basis of KATP channel function, (4) the first molecular model of the Kir channel pore, (5) transgenic animal models of diabetes, hyperinsulinism, and cardiac dysrrhythmias. Current major challenges range from atomic resolution of Kir channel structure and function, to further elucidation of the roles of Kir channels in organ function and dysfunction in the heart, pancreas, vasculature and brain.

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  • 18 Similar Profiles
KATP Channels Medicine & Life Sciences
Adenosine Triphosphate Medicine & Life Sciences
Potassium Channels Medicine & Life Sciences
Inwardly Rectifying Potassium Channel Medicine & Life Sciences
Sulfonylurea Receptors Medicine & Life Sciences
Mutation Medicine & Life Sciences
Polyamines Medicine & Life Sciences
Insulin Medicine & Life Sciences

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Research Output 1985 2020

Atomistic basis of opening and conduction in mammalian inward rectifier potassium (Kir2.2) channels

Zangerl-Plessl, E. M., Lee, S. J., Maksaev, G., Bernsteiner, H., Ren, F., Yuan, P., Stary-Weinzinger, A. & Nichols, C. G., Jan 6 2020, In : The Journal of general physiology. 152, 1

Research output: Contribution to journalArticle

Open Access
Inwardly Rectifying Potassium Channel
Ions
Ligands
Potassium Channels
Phosphatidylinositols
1 Citation (Scopus)

ABCC9-related Intellectual disability Myopathy Syndrome is a KATP channelopathy with loss-of-function mutations in ABCC9

Smeland, M. F., McClenaghan, C., Roessler, H. I., Savelberg, S., Hansen, G. Å. M., Hjellnes, H., Arntzen, K. A., Müller, K. I., Dybesland, A. R., Harter, T., Sala-Rabanal, M., Emfinger, C. H., Huang, Y., Singareddy, S. S., Gunn, J., Wozniak, D. F., Kovacs, A., Massink, M., Tessadori, F., Kamel, S. M. & 5 others, Bakkers, J., Remedi, M. S., Van Ghelue, M., Nichols, C. G. & van Haaften, G., Dec 1 2019, In : Nature communications. 10, 1, 4457.

Research output: Contribution to journalArticle

Open Access
Channelopathies
disabilities
KATP Channels
Sulfonylurea Receptors
Muscular Diseases
2 Citations (Scopus)

Beta-cell excitability and excitability-driven diabetes in adult Zebrafish islets

Emfinger, C. H., Lőrincz, R., Wang, Y., York, N. W., Singareddy, S. S., Ikle, J. M., Tryon, R. C., McClenaghan, C., Shyr, Z. A., Huang, Y., Reissaus, C. A., Meyer, D., Piston, D. W., Hyrc, K., Remedi, M. S. & Nichols, C. G., Jun 2019, In : Physiological Reports. 7, 11, e14101.

Research output: Contribution to journalArticle

Open Access
Zebrafish
Calcium
Glucose
Fishes
KATP Channels
1 Citation (Scopus)

Cantú syndrome: Findings from 74 patients in the International Cantú Syndrome Registry

Grange, D. K., Roessler, H. I., McClenaghan, C., Duran, K., Shields, K., Remedi, M. S., Knoers, N. V. A. M., Lee, J. M., Kirk, E. P., Scurr, I., Smithson, S. F., Singh, G. K., van Haelst, M. M., Nichols, C. G. & van Haaften, G., Dec 1 2019, In : American Journal of Medical Genetics, Part C: Seminars in Medical Genetics. 181, 4, p. 658-681 24 p.

Research output: Contribution to journalArticle

Open Access
Registries
KATP Channels
Genotype
Hypertrichosis
Polyhydramnios
1 Citation (Scopus)

Genetic Discovery of ATP-Sensitive K+ Channels in Cardiovascular Diseases

Huang, Y., Hu, D., Huang, C. & Nichols, C. G., May 1 2019, In : Circulation: Arrhythmia and Electrophysiology. 12, 5, e007322.

Research output: Contribution to journalReview article

Cardiovascular Diseases
Adenosine Triphosphate
Sulfonylurea Receptors
Physiological Phenomena
KATP Channels