• 1178 Citations
20042019

Research output per year

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Personal profile

Research interests

I am interested in the genetic determinants of neuronal differentiation and the role that mutations in these pathways play in disorders of neuronal development. Specifically, I am studying how ubiquitin signaling regulates heterochromatin formation and epigenetic maturation after neuronal progenitors exit mitosis. Through unbiased and rational approaches, we have identified several substrates that directly mediate these processes and are inappropriately stabilized following mutation in an E3 ubiquitin ligase. I employ diverse methods ranging from in vitro biochemistry through genetic mouse models, which permits in vivo examination of disease pathogenesis from the molecular and cellular through behavior.

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Research Output

  • 1178 Citations
  • 20 Article
  • 1 Comment/debate
  • 1 Review article
  • 1 Scopus citations

    Autoimmune Encephalitis with Multiple Autoantibodies: A Diagnostic and Therapeutic Challenge

    Kim, A. E., Kang, P., Bucelli, R. C., Ferguson, C. J., Schmidt, R. E., Varadhachary, A. S. & Day, G. S., Jan 1 2018, In : Neurologist. 23, 2, p. 55-59 5 p.

    Research output: Contribution to journalArticle

  • 7 Scopus citations

    Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development

    Binder, Z. A., Thorne, A. H., Bakas, S., Wileyto, E. P., Bilello, M., Akbari, H., Rathore, S., Ha, S. M., Zhang, L., Ferguson, C. J., Dahiya, S., Bi, W. L., Reardon, D. A., Idbaih, A., Felsberg, J., Hentschel, B., Weller, M., Bagley, S. J., Morrissette, J. J. D., Nasrallah, M. P. & 7 others, Ma, J., Zanca, C., Scott, A. M., Orellana, L., Davatzikos, C., Furnari, F. B. & O'Rourke, D. M., Jul 9 2018, In : Cancer Cell. 34, 1, p. 163-177.e7

    Research output: Contribution to journalArticle

  • 41 Scopus citations

    Focal traumatic rupture of a dermoid cyst in a pediatric patient: case report and literature review

    Akbari, S. H. A., Somasundaram, A., Ferguson, C. J., Roland, J. L., Smyth, M. D. & Strahle, J. M., Dec 1 2018, In : Child's Nervous System. 34, 12, p. 2485-2490 6 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    In vivo [18F]-AV-1451 tau-PET imaging in sporadic Creutzfeldt-Jakob disease

    Day, G. S., Gordon, B. A., Perrin, R. J., Cairns, N. J., Beaumont, H., Schwetye, K., Ferguson, C., Sinha, N., Bucelli, R., Musiek, E. S., Ghoshal, N., Ponisio, M. R., Vincent, B., Mishra, S., Jackson, K., Morris, J. C., Benzinger, T. L. S. & Ances, B. M., Mar 6 2018, In : Neurology. 90, 10, p. E896-E906

    Research output: Contribution to journalArticle

  • 9 Scopus citations