Microglia are resident macrophages of the brain that engage in a variety of processes essential for brain development and homeostasis. Microglia dysfunction (e.g., dysregulation of target uptake, synaptic pruning, proinflammatory cytokine production) contributes to the pathogenesis of neurodegenerative diseases including Alzheimer’s Disease and neurodevelopmental conditions, such as Autism Spectrum Disorder. My lab is interested in the regulation of microglial phenotypes during development and in disease, and how alterations in microglia physiology impact neuronal circuitry and enhance the risk for neurological disorders, through the lens of epigenetics and transcriptomics. 

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