Research output per year
Research output per year
Personal profile
Research interests
My focus is on developing and applying computational tools to provide insight into the origins and progression of cancer. This includes understanding the clonal architecture of tumors and how they evolve in response to therapy, with a special focus on hematologic cancers. I also study effective design and targeting of cancer immunotherapies, developing open-source software for interpreting and visualizing genomic data, and integrative analysis that translates multi-dimensional genomic data into both functional and actionable contexts.
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Collaborations and top research areas from the last five years
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Molecular responses in decitabine-and decitabine/venetoclax-Treated patients with acute myeloid leukemia and myelodysplastic syndromes
Gruszczynska, A., Maiti, A., Miller, C. A., Ramakrishnan, S. M., Link, D. C., Uy, G. L., Petti, A. A., Hayes, K., Nardo, C. D. D., Ravandi, F., Ley, T. J., Spencer, D. H., Gao, F., Konopleva, M. Y. & Welch, J. S., 2024, In: Haematologica.Research output: Contribution to journal › Letter › peer-review
Open Access -
PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells
Katerndahl, C. D. S., Rogers, O. R. S., Day, R. B., Xu, Z., Helton, N. M., Ramakrishnan, S. M., Miller, C. A. & Ley, T. J., Apr 30 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 18, e2317690121.Research output: Contribution to journal › Article › peer-review
Open Access -
Proteogenomic analysis reveals cytoplasmic sequestration of RUNX1 by the acute myeloid leukemia–initiating CBFB::MYH11 oncofusion protein
Day, R. B., Hickman, J. A., Xu, Z., Katerndahl, C. D. S., Ferraro, F., Ramakrishnan, S. M., Erdmann-Gilmore, P., Sprung, R. W., Mi, Y., Townsend, R. R., Miller, C. A. & Ley, T. J., Feb 15 2024, In: Journal of Clinical Investigation. 134, 4, 1e176311.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Rapid and accurate remethylation of DNA in Dnmt3a-deficient hematopoietic cells with restoration of DNMT3A activity
Li, Y., Abel, H. J., Cai, M., LaValle, T. A., Yin, T., Helton, N. M., Smith, A. M., Miller, C. A. & Ley, T. J., Feb 2024, In: Science Advances. 10, 5, eadk8598.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer (Nature Genetics, (2020), 52, 3, (294-305), 10.1038/s41588-019-0564-y)
PCAWG-Structural Variation Working Group & PCAWG Consortium, Jun 2023, In: Nature Genetics. 55, 6, p. 1079 1 p.Research output: Contribution to journal › Comment/debate
Open Access