Christopher Maher

Associate Professor of Medicine, Associate Professor of Biomedical Engineering, Associate Professor of Biomedical Engineering

    • 16062 Citations
    20012020

    Research output per year

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    Personal profile

    Research interests

    Our research focuses integrative cancer biology research for the purpose of translating genome-based knowledge into novel diagnostic, prognostic, therapeutic strategies in cancer research. In order to accomplish this, we have focused on the development of novel computational tools to integrate and interpret high-throughput genomic data collections to better understand cancer biology. For example, we have successfully developed tools for identifying clinical relevant gene fusions and novel long intergenic non-coding RNAs in prostate cancer. Building upon this work, we are actively integrating novel solid tumor genomics data collections to identify altered mutations and pathways, explore these alterations using in vitro and in vivo models, and ultimately work with clinicians to translate these findings into the clinic.

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    Research Output

    Cell-free DNA alterations in the AR enhancer and locus predict resistance to AR-directed therapy in patients with metastatic prostate cancer

    Dang, H., Chauhan, P. S., Ellis, H., Feng, W., Harris, P. K., Smith, G., Qiao, M., Dienstbach, K., Beck, R., Atkocius, A., Qaium, F., Luo, J., Michalski, J., Picus, J., Pachynski, R., Maher, C. & Chaudhuri, A. A., 2020, In : JCO Precision Oncology. 4, p. 680-713 34 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Gene Fusion Discovery with INTEGRATE

    Zhang, J. & Maher, C. A., Jan 1 2020, Methods in Molecular Biology. Humana Press Inc., p. 41-68 28 p. (Methods in Molecular Biology; vol. 2079).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • Heparin-based hydrogel scaffolding alters the transcriptomic profile and increases the chemoresistance of MDA-MB-231 triple-negative breast cancer cells

    Menon, N., Dang, H. X., Datla, U. S., Moarefian, M., Lawrence, C. B., Maher, C. A. & Jones, C. N., May 21 2020, In : Biomaterials Science. 8, 10, p. 2786-2796 11 p.

    Research output: Contribution to journalArticle

    Open Access
  • Long non-coding RNA LCAL62 / LINC00261 is associated with lung adenocarcinoma prognosis

    Dang, H. X., White, N. M., Rozycki, E. B., Felsheim, B. M., Watson, M. A., Govindan, R., Luo, J. & Maher, C. A., Mar 2020, In : Heliyon. 6, 3, e03521.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    Long non-coding RNA RAMS11 promotes metastatic colorectal cancer progression

    Silva-Fisher, J. M., Dang, H. X., White, N. M., Strand, M. S., Krasnick, B. A., Rozycki, E. B., Jeffers, G. G. L., Grossman, J. G., Highkin, M. K., Tang, C., Cabanski, C. R., Eteleeb, A., Mudd, J., Goedegebuure, S. P., Luo, J., Mardis, E. R., Wilson, R. K., Ley, T. J., Lockhart, A. C., Fields, R. C. & 1 others, Maher, C. A., Dec 1 2020, In : Nature communications. 11, 1, 2156.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations