• 4634 Citations
1980 …2020

Research output per year

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Personal profile

Research interests

This lab studies the functional and physiological roles of a family of ion channel proteins (e.g., the Ca2+ and voltage-regulated BK-type potassium channel) that are widely expressed (e.g., most neurons, muscle, secretory epithelium, kidney, endocrine cells) and have been linked to diverse conditions such as asthma, mental retardation, hypertension, colitis, epilepsy, and tumor growth. The behavior of BK channels varies enormously among different tissues, primarily because of regulatory subunits (beta and gamma) that define tissue-specific properties and cell-specific functional behavior. This lab identifies new subunits, determines their localization, function, and potential physiological roles, and uses genetic knock-out (KO) of specific subunits in mice to assess further the potential physiological and pathological roles of specific channels. Current emphases include: the beta3 (Kcnmb3) subunit for which KO results in resistance to ketamine-induced sedation and the gamma1 (Lrrc26) subunit for which KO confers severe sensitivity to colitis and enhanced colonic tumor growth.

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Research Output

  • 4634 Citations
  • 87 Article
  • 9 Comment/debate
  • 5 Review article
  • 1 Scopus citations

    LRRC52 regulates BK channel function and localization in mouse cochlear inner hair cells

    Lingle, C. J., Martinez-Espinosa, P. L., Yang-Hood, A., Boero, L. E., Payne, S., Persic, D., V-Ghaffari, B., Xiao, M., Zhou, Y., Xia, X. M., Pyott, S. J. & Rutherford, M. A., Sep 10 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 37, p. 18397-18403 7 p.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations

    Regulation of BK Channels by Beta and Gamma Subunits

    Gonzalez-Perez, V. & Lingle, C. J., Feb 10 2019, In : Annual Review of Physiology. 81, p. 113-137 25 p.

    Research output: Contribution to journalReview article

  • 14 Scopus citations

    BK channel inhibition by strong extracellular acidification

    Zhou, Y., Xia, X. M. & Lingle, C. J., Jul 2 2018, In : eLife. 7, e38060.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations
  • 3 Scopus citations