• 5140 Citations
1981 …2020

Research output per year

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Personal profile

Research interests

The focus of our laboratory is to define the role of proteases in immunity and autoimmunity. Traditionally, proteases are viewed as effector molecules owing to their ability to digest extracellular matrix (ECM). More recently, studies have extended the role of proteases beyond the degradation of ECM. For example, we have generated a mouse deficient in cathepsin C (or dipeptidyl peptidase I, DPPI) and established that this protease is crucial in the activation of many serine proteases including lymphocyte-associated granzymes, mast cell-derived chymase, and neutrophil-specific cathepsin G, neutrophil elastase and proteinase 3. We have further shown that DPPI and the serine proteases it activates are key molecules involved in cell-mediated cytotoxicity and leukocyte recruitment at sites of inflammation. The absence of DPPI rendered mice resistant to experimentally induced arthritis and death in a model of sepsis. Therefore, a more complete understanding of the functional physiology of proteases should lead to a better understanding of immune effector cell biology and may potential lead to novel therapeutic interventions.

Areas of Clinical Interest

Rheumatology, arthritis, inflammation and proteases

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Research Output

Induction of WNT16 via peptide-mRNA nanoparticle-based delivery maintains cartilage homeostasis

Yan, H., Hu, Y., Akk, A., Rai, M. F., Pan, H., Wickline, S. A. & Pham, C. T. N., Jan 2020, In : Pharmaceutics. 12, 1, 73.

Research output: Contribution to journalArticle

Open Access
  • Applications of RNA interference in the treatment of arthritis

    Rai, M. F., Pan, H., Yan, H., Sandell, L. J., Pham, C. T. N. & Wickline, S. A., Dec 2019, In : Translational Research. 214, p. 1-16 16 p.

    Research output: Contribution to journalReview article

  • 6 Scopus citations

    Complement activation on neutrophils initiates endothelial adhesion and extravasation

    Akk, A., Springer, L. E., Yang, L., Hamilton-Burdess, S., Lambris, J. D., Yan, H., Hu, Y., Wu, X., Hourcade, D. E., Miller, M. J. & Pham, C. T. N., Oct 2019, In : Molecular Immunology. 114, p. 629-642 14 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Designer Stem Cells: Genome Engineering and the Next Generation of Cell-Based Therapies

    Guilak, F., Pferdehirt, L., Ross, A. K., Choi, Y. R., Collins, K. H., Nims, R. J., Katz, D. B., Klimak, M., Tabbaa, S. & Pham, C. T. N., Jun 2019, In : Journal of Orthopaedic Research. 37, 6, p. 1287-1293 7 p.

    Research output: Contribution to journalReview article

    Open Access
  • 5 Scopus citations

    Development of a peptide-siRNA nanocomplex targeting NF- κB for efficient cartilage delivery

    Yan, H., Duan, X., Pan, H., Akk, A., Sandell, L. J., Wickline, S. A., Rai, M. F. & Pham, C. T. N., Dec 1 2019, In : Scientific reports. 9, 1, 442.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations