• 1592 Citations
20052020

Research output per year

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Personal profile

Research interests

Our laboratory focuses on the adaptation of Mycobacteria to host-inflicted stresses and persistent infection. At least 30% of the world’s population is infected with latent Mycobacterium tuberculosis, which in some individuals will reactivate and cause an estimated 1.8 million deaths a year. This health crisis is exacerbated by the alarming emergence of multi-drug and extensively drug resistant strains. The inadequacies of present Tuberculosis therapies demand the discovery of new agents to treat M. tuberculosis infection, which requires insight into the pathways involved in M. tuberculosis pathogenesis. The general approach of our laboratory is to integrate in vivo disease modeling, molecular biology, and biochemistry to provide answers to the fundamental biological questions regarding molecular pathogenesis and yield therapeutic strategies for treatment of mycobacterial infections.

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Research Output

A Flexible and Deadly Way to Control Salmonella Infection

Kinsella, R. L. & Stallings, C. L., Sep 15 2020, In : Immunity. 53, 3, p. 471-473 3 p.

Research output: Contribution to journalArticle

  • Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes

    Wang, Y. T., Zaitsev, K., Lu, Q., Li, S., Schaiff, W. T., Kim, K. W., Droit, L., Wilen, C. B., Desai, C., Balce, D. R., Orchard, R. C., Orvedahl, A., Park, S., Kreamalmeyer, D., Handley, S. A., Pfeifer, J. D., Baldridge, M. T., Artyomov, M. N., Stallings, C. L. & Virgin, S., Feb 1 2020, In : Nature microbiology. 5, 2, p. 272-281 10 p.

    Research output: Contribution to journalLetter

  • A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host

    Harding, C. M., Nasr, M. A., Scott, N. E., Goyette-Desjardins, G., Nothaft, H., Mayer, A. E., Chavez, S. M., Huynh, J. P., Kinsella, R. L., Szymanski, C. M., Stallings, C. L., Segura, M. & Feldman, M. F., Dec 1 2019, In : Nature communications. 10, 1, 891.

    Research output: Contribution to journalArticle

    Open Access
  • 14 Scopus citations

    A promising bioconjugate vaccine against hypervirulent Klebsiella pneumoniae

    Feldman, M. F., Mayer Bridwell, A. E., Scott, N. E., Vinogradov, E., McKee, S. R., Chavez, S. M., Twentyman, J., Stallings, C. L., Rosen, D. A. & Harding, C. M., Sep 10 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 37, p. 18655-18663 9 p.

    Research output: Contribution to journalArticle

    Open Access
  • 9 Scopus citations
    Open Access
  • 5 Scopus citations