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Research interests

I am interested in understanding the pathophysiology of cerebrovascular disease by leveraging big data approaches in combining genetic, clinical, and neuroimaging data, with the overarching goal of deriving clinically relevant information to drive innovations in treatment strategies, and improve precision in clinical decision-making and risk stratification. In particular, my current efforts focus on dissecting the contribution of cerebral small vessel disease in vascular and mixed dementias using multidisciplinary and multiphenotype approaches in order to develop strategies for prevention and treatment of cognitive decline in cerebrovascular and neurodegenerative disorders.

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  • Association of Stroke Lesion Pattern and White Matter Hyperintensity Burden With Stroke Severity and Outcome

    Bonkhoff, A. K., Hong, S., Bretzner, M., Schirmer, M. D., Regenhardt, R. W., Arsava, E. M., Donahue, K., Nardin, M., Dalca, A., Giese, A. K., Etherton, M. R., Hancock, B. L., Mocking, S. J. T., Mcintosh, E., Attia, J., Benavente, O., Cole, J. W., Donatti, A., Griessenauer, C., Heitsch, L., & 37 othersHolmegaard, L., Jood, K., Jimenez-Conde, J., Kittner, S., Lemmens, R., Levi, C., Mcdonough, C. W., Meschia, J., Phuah, C. L., Rolfs, A., Ropele, S., Rosand, J., Roquer, J., Rundek, T., Sacco, R. L., Schmidt, R., Sharma, P., Slowik, A., Soederholm, M., Sousa, A., Stanne, T. M., Strbian, D., Tatlisumak, T., Thijs, V., Vagal, A., Wasselius, J., Woo, D., Zand, R., Mcardle, P., Worrall, B. B., Jern, C., Lindgren, A. G., Maguire, J., Golland, P., Bzdok, D., Wu, O. & Rost, N. S., Sep 27 2022, In: Neurology. 99, 13, p. E1364-E1379

    Research output: Contribution to journalArticlepeer-review

  • Deep profiling of multiple ischemic lesions in a large, multi-center cohort: Frequency, spatial distribution, and associations to clinical characteristics

    the MRI-GENIE GISCOME Investigators, the International Stroke Genetics Consortium, Aug 25 2022, In: Frontiers in Neuroscience. 16, 994458.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • Multi-Ancestry GWAS reveals excitotoxicity associated with outcome after ischaemic stroke

    Ibanez, L., Heitsch, L., Carrera, C., Farias, F. H. G., Del Aguila, J. L., Dhar, R., Budde, J., Bergmann, K., Bradley, J., Harari, O., Phuah, C. L., Lemmens, R., Souza, A. A. V. O., Moniche, F., Cabezas-Juan, A., Arenillas, J. F., Krupinksi, J., Cullell, N., Torres-Aguila, N., Muiño, E., & 56 othersCárcel-Márquez, J., Marti-Fabregas, J., Delgado-Mederos, R., Marin-Bueno, R., Hornick, A., Vives-Bauza, C., Navarro, R. D., Tur, S., Jimenez, C., Obach, V., Segura, T., Serrano-Heras, G., Chung, J. W., Roquer, J., Soriano-Tarraga, C., Giralt-Steinhauer, E., Mola-Caminal, M., Pera, J., Lapicka-Bodzioch, K., Derbisz, J., Davalos, A., Lopez-Cancio, E., Muñoz, L., Tatlisumak, T., Molina, C., Ribo, M., Bustamante, A., Sobrino, T., Castillo-Sanchez, J., Campos, F., Rodriguez-Castro, E., Arias-Rivas, S., Rodríguez-Yáñez, M., Herbosa, C., Ford, A. L., Gutierrez-Romero, A., Uribe-Pacheco, R., Arauz, A., Lopes-Cendes, I., Lowenkopf, T., Barboza, M. A., Amini, H., Stamova, B., Ander, B. P., Sharp, F. R., Moon Kim, G., Bang, O. Y., Jimenez-Conde, J., Slowik, A., Stribian, D., Tsai, E. A., Burkly, L. C., Montaner, J., Fernandez-Cadenas, I., Lee, J. M. & Cruchaga, C., Jul 1 2022, In: Brain. 145, 7, p. 2394-2406 13 p.

    Research output: Contribution to journalArticlepeer-review

    3 Scopus citations
  • Sex-specific lesion pattern of functional outcomes after stroke

    Bonkhoff, A. K., Bretzner, M., Hong, S., Schirmer, M. D., Cohen, A., Regenhardt, R. W., Donahue, K. L., Nardin, M. J., Dalca, A. V., Giese, A. K., Etherton, M. R., Hancock, B. L., Mocking, S. J. T., McIntosh, E. C., Attia, J., Benavente, O. R., Bevan, S., Cole, J. W., Donatti, A., Griessenauer, C. J., & 38 othersHeitsch, L., Holmegaard, L., Jood, K., Jimenez-Conde, J., Kittner, S. J., Lemmens, R., Levi, C. R., McDonough, C. W., Meschia, J. F., Phuah, C. L., Rolfs, A., Ropele, S., Rosand, J., Roquer, J., Rundek, T., Sacco, R. L., Schmidt, R., Sharma, P., Slowik, A., Söderholm, M., Sousa, A., Stanne, T. M., Strbian, D., Tatlisumak, T., Thijs, V., Vagal, A., Wasselius, J., Woo, D., Zand, R., McArdle, P. F., Worrall, B. B., Jern, C., Lindgren, A. G., Maguire, J., Fox, M. D., Bzdok, D., Wu, O. & Rost, N. S., 2022, In: Brain Communications. 4, 2, fcac020.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    3 Scopus citations
  • Vascular endothelial-cadherin as a marker of endothelial injury in preclinical Alzheimer disease

    Tarawneh, R., Kasper, R. S., Sanford, J., Phuah, C. L., Hassenstab, J. & Cruchaga, C., 2022, (Accepted/In press) In: Annals of Clinical and Translational Neurology.

    Research output: Contribution to journalArticlepeer-review

    Open Access